Next Article in Journal
Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia
Previous Article in Journal
Correlation between Blunted Nocturnal Decrease in Diastolic Blood Pressure and Oxidative Stress: An Observational Study
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders

Lawrence D. Longo MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
*
Authors to whom correspondence should be addressed.
Antioxidants 2022, 11(12), 2432; https://doi.org/10.3390/antiox11122432
Submission received: 8 November 2022 / Revised: 28 November 2022 / Accepted: 6 December 2022 / Published: 9 December 2022

Abstract

Blood pressure is determined by cardiac output and peripheral vascular resistance. The L-type voltage-gated Ca2+ (Cav1.2) channel in small arteries and arterioles plays an essential role in regulating Ca2+ influx, vascular resistance, and blood pressure. Hypertension and preeclampsia are characterized by high blood pressure. In addition, diabetes has a high prevalence of hypertension. The etiology of these disorders remains elusive, involving the complex interplay of environmental and genetic factors. Common to these disorders are oxidative stress and vascular dysfunction. Reactive oxygen species (ROS) derived from NADPH oxidases (NOXs) and mitochondria are primary sources of vascular oxidative stress, whereas dysfunction of the Cav1.2 channel confers increased vascular resistance in hypertension. This review will discuss the importance of ROS derived from NOXs and mitochondria in regulating vascular Cav1.2 and potential roles of ROS-mediated Cav1.2 dysfunction in aberrant vascular function in hypertension, diabetes, and preeclampsia.
Keywords: hypertension; gestational diabetes; preeclampsia; reactive oxygen species; Cav1.2; myogenic tone hypertension; gestational diabetes; preeclampsia; reactive oxygen species; Cav1.2; myogenic tone
Graphical Abstract

Share and Cite

MDPI and ACS Style

Hu, X.-Q.; Zhang, L. Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders. Antioxidants 2022, 11, 2432. https://doi.org/10.3390/antiox11122432

AMA Style

Hu X-Q, Zhang L. Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders. Antioxidants. 2022; 11(12):2432. https://doi.org/10.3390/antiox11122432

Chicago/Turabian Style

Hu, Xiang-Qun, and Lubo Zhang. 2022. "Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders" Antioxidants 11, no. 12: 2432. https://doi.org/10.3390/antiox11122432

APA Style

Hu, X.-Q., & Zhang, L. (2022). Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders. Antioxidants, 11(12), 2432. https://doi.org/10.3390/antiox11122432

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop