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Antioxidants
Volume 11
Issue 2
10.3390/antiox11020367
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Article

Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity

by
Ines Castangia
1,
Maria Manconi
1,*,
Mohamad Allaw
1,
Matteo Perra
1,
Germano Orrù
2,
Sara Fais
2,
Alessandra Scano
2,
Elvira Escribano-Ferrer
3,
Mansureh Ghavam
4,
Maryam Rezvani
1,5 and
Maria Letizia Manca
1
1
Department of Scienze della Vita e dell’Ambiente, Drug Science Division, University of Cagliari, 09124 Cagliari, Italy
2
Molecular Biology Service Laboratory, Department of Surgical Science, University of Cagliari, 09124 Cagliari, Italy
3
Biopharmaceutics and Pharmacokinetics Unit, Institute for Nanoscience and Nanotechnology, University of Barcelona, 08007 Barcelona, Spain
4
Department of Range and Watershed Management, Faculty of Natural Resources and Earth Sciences, University of Kashan, Kashan 8731753153, Iran
5
Department of Food Science, College of Agriculture, University of Tabriz, Tabriz 5166616471, Iran
*
Author to whom correspondence should be addressed.
Antioxidants 2022, 11(2), 367; https://doi.org/10.3390/antiox11020367
Submission received: 31 December 2021 / Revised: 4 February 2022 / Accepted: 8 February 2022 / Published: 11 February 2022
(This article belongs to the Special Issue Total Antioxidant Capacity in Health and Disease)
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Abstract

The aim of this work was the simultaneous loading of quercetin and mint essential oil (mint oil) in phospholipid vesicles specifically tailored to obtain an antibacterial and antioxidant mouthwash. The vesicles were prepared using soy lecithin and Tween 80 as bilayer components, and a mixture of phosphate buffer solution (33%), propylene glycol (33%) and ethanol (33%) as dispersing phase. The formation of regularly shaped, spherical and unilamellar vesicles was confirmed by cryogenic transmission electron microscopy analyses. Similarly, light scattering results disclosed that the size of the vesicles increased by increasing the concentration of mint oil, but at the same time the high amount of mint oil ensured high stability, as the size of these vesicles remained unchanged during 12 months of storage. All tested formulations were highly biocompatible towards epithelial cells and capable of counteracting oxidative cell damages caused by hydrogen peroxide. Moreover, the vesicles prepared with the highest concentration of mint oil inhibited the proliferation of the cariogenic Streptococcus mutans (S. mutans) and Lactobacillus acidophilus (L. acidophilus).
Keywords: quercetin; phospholipid vesicles; glycols; ethanol; oral mucosa; oral cavity bacteria quercetin; phospholipid vesicles; glycols; ethanol; oral mucosa; oral cavity bacteria

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MDPI and ACS Style

Castangia, I.; Manconi, M.; Allaw, M.; Perra, M.; Orrù, G.; Fais, S.; Scano, A.; Escribano-Ferrer, E.; Ghavam, M.; Rezvani, M.; et al. Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity. Antioxidants 2022, 11, 367. https://doi.org/10.3390/antiox11020367

AMA Style

Castangia I, Manconi M, Allaw M, Perra M, Orrù G, Fais S, Scano A, Escribano-Ferrer E, Ghavam M, Rezvani M, et al. Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity. Antioxidants. 2022; 11(2):367. https://doi.org/10.3390/antiox11020367

Chicago/Turabian Style

Castangia, Ines, Maria Manconi, Mohamad Allaw, Matteo Perra, Germano Orrù, Sara Fais, Alessandra Scano, Elvira Escribano-Ferrer, Mansureh Ghavam, Maryam Rezvani, and et al. 2022. "Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity" Antioxidants 11, no. 2: 367. https://doi.org/10.3390/antiox11020367

APA Style

Castangia, I., Manconi, M., Allaw, M., Perra, M., Orrù, G., Fais, S., Scano, A., Escribano-Ferrer, E., Ghavam, M., Rezvani, M., & Manca, M. L. (2022). Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity. Antioxidants, 11(2), 367. https://doi.org/10.3390/antiox11020367

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