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Review

Can Antioxidants Reduce the Toxicity of Bisphenol?

by
Wanda Mączka
*,
Małgorzata Grabarczyk
* and
Katarzyna Wińska
*
Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland
*
Authors to whom correspondence should be addressed.
Antioxidants 2022, 11(2), 413; https://doi.org/10.3390/antiox11020413
Submission received: 28 January 2022 / Revised: 14 February 2022 / Accepted: 16 February 2022 / Published: 18 February 2022
(This article belongs to the Special Issue Oxidative Stress and Inflammation in Cancer)

Abstract

BPA is still the subject of extensive research due to its widespread use, despite its significant toxicity resulting not only from its negative impact on the endocrine system but also from disrupting the organism’s oxidative homeostasis. At the molecular level, bisphenol A (BPA) causes an increased production of ROS and hence a change in the redox balance, mitochondrial dysfunction, and modulation of cell signaling pathways. Importantly, these changes accumulate in animals and humans, and BPA toxicity may be aggravated by poor diet, metabolic disorders, and coexisting diseases. Accordingly, approaches using antioxidants to counteract the negative effects of BPA are being considered. The preliminary results that are described in this paper are promising, however, it should be emphasized that further studies are required to determine the optimal dosage and treatment regimen to counteract BPA toxicity. It also seems necessary to have a more holistic approach showing, on the one hand, the influence of BPA on the overall human metabolism and, on the other hand, the influence of antioxidants in doses that are acceptable with the diet on BPA toxicity. This is due in part to the fact that in many cases, the positive effect of antioxidants in in vitro studies is not confirmed by clinical studies. For this reason, further research into the molecular mechanisms of BPA activity is also recommended.
Keywords: bisphenol A; antioxidants; taurine; quercetin; geinstein; curcumin; lycopene; luteolin; naringin; melatonin bisphenol A; antioxidants; taurine; quercetin; geinstein; curcumin; lycopene; luteolin; naringin; melatonin

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MDPI and ACS Style

Mączka, W.; Grabarczyk, M.; Wińska, K. Can Antioxidants Reduce the Toxicity of Bisphenol? Antioxidants 2022, 11, 413. https://doi.org/10.3390/antiox11020413

AMA Style

Mączka W, Grabarczyk M, Wińska K. Can Antioxidants Reduce the Toxicity of Bisphenol? Antioxidants. 2022; 11(2):413. https://doi.org/10.3390/antiox11020413

Chicago/Turabian Style

Mączka, Wanda, Małgorzata Grabarczyk, and Katarzyna Wińska. 2022. "Can Antioxidants Reduce the Toxicity of Bisphenol?" Antioxidants 11, no. 2: 413. https://doi.org/10.3390/antiox11020413

APA Style

Mączka, W., Grabarczyk, M., & Wińska, K. (2022). Can Antioxidants Reduce the Toxicity of Bisphenol? Antioxidants, 11(2), 413. https://doi.org/10.3390/antiox11020413

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