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Antioxidants
Volume 11
Issue 4
10.3390/antiox11040640
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Article

Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study

by
Martin Helan
1,2,3,
Jan Malaska
3,4,
Josef Tomandl
5,
Jiri Jarkovsky
6,
Katerina Helanova
3,7,
Klara Benesova
6,
Michal Sitina
1,2,3,
Milan Dastych
8,
Tomas Ondrus
3,7,
Monika Pavkova Goldbergova
9,
Roman Gal
3,4,
Petr Lokaj
3,7,
Marie Tomandlova
5,* and
Jiri Parenica
3,7
1
Department of Anaesthesiology and Intensive Care, St. Anne’s University Hospital Brno, 656 91 Brno, Czech Republic
2
International Clinical Research Center (ICRC), St. Anne’s University Hospital Brno, 656 91 Brno, Czech Republic
3
Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
4
Department of Anaesthesiology and Intensive Care Medicine, University Hospital Brno, 625 00 Brno, Czech Republic
5
Department of Biochemistry, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
6
Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
7
Department of Internal Medicine and Cardiology, University Hospital Brno, 625 00 Brno, Czech Republic
8
Department of Laboratory Methods, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
9
Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
*
Author to whom correspondence should be addressed.
Antioxidants 2022, 11(4), 640; https://doi.org/10.3390/antiox11040640
Submission received: 10 February 2022 / Revised: 21 March 2022 / Accepted: 24 March 2022 / Published: 26 March 2022
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Abstract

Septic shock is a major cause of mortality in ICU patients, its pathophysiology is complex and not properly understood. Oxidative stress seems to be one of the most important mechanisms of shock progression to multiple organ failure. In the present pilot study, we have analysed eight oxidative-stress-related biomarkers in seven consecutive time points (i.e., the first seven days) in 21 septic shock patients admitted to the ICU. Our objective was to describe the kinetics of four biomarkers related to pro-oxidative processes (nitrite/nitrate, malondialdehyde, 8-oxo-2′-deoxyguanosine, soluble endoglin) compared to four biomarkers of antioxidant processes (the ferric reducing ability of plasma, superoxide dismutase, asymmetric dimethylarginine, mid-regional pro-adrenomedullin) and four inflammatory biomarkers (CRP, IL-6, IL-10 and neopterin). Furthermore, we analysed each biomarker’s ability to predict mortality at the time of admission and 12 h after admission. Although a small number of study subjects were recruited, we have identified four promising molecules for further investigation: soluble endoglin, superoxide dismutase, asymmetric dimethylarginine and neopterin.
Keywords: sepsis; septic shock; oxidative stress; antioxidant; biomarker; soluble endoglin; superoxide dismutase; asymmetric dimethylarginine; neopterin sepsis; septic shock; oxidative stress; antioxidant; biomarker; soluble endoglin; superoxide dismutase; asymmetric dimethylarginine; neopterin

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MDPI and ACS Style

Helan, M.; Malaska, J.; Tomandl, J.; Jarkovsky, J.; Helanova, K.; Benesova, K.; Sitina, M.; Dastych, M.; Ondrus, T.; Pavkova Goldbergova, M.; et al. Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study. Antioxidants 2022, 11, 640. https://doi.org/10.3390/antiox11040640

AMA Style

Helan M, Malaska J, Tomandl J, Jarkovsky J, Helanova K, Benesova K, Sitina M, Dastych M, Ondrus T, Pavkova Goldbergova M, et al. Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study. Antioxidants. 2022; 11(4):640. https://doi.org/10.3390/antiox11040640

Chicago/Turabian Style

Helan, Martin, Jan Malaska, Josef Tomandl, Jiri Jarkovsky, Katerina Helanova, Klara Benesova, Michal Sitina, Milan Dastych, Tomas Ondrus, Monika Pavkova Goldbergova, and et al. 2022. "Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study" Antioxidants 11, no. 4: 640. https://doi.org/10.3390/antiox11040640

APA Style

Helan, M., Malaska, J., Tomandl, J., Jarkovsky, J., Helanova, K., Benesova, K., Sitina, M., Dastych, M., Ondrus, T., Pavkova Goldbergova, M., Gal, R., Lokaj, P., Tomandlova, M., & Parenica, J. (2022). Kinetics of Biomarkers of Oxidative Stress in Septic Shock: A Pilot Study. Antioxidants, 11(4), 640. https://doi.org/10.3390/antiox11040640

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