Next Article in Journal
Anti-Oxidative Therapy in Islet Cell Transplantation
Next Article in Special Issue
Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice
Previous Article in Journal
A Whiff of Sulfur: One Wind a Day Keeps the Doctor Away
Previous Article in Special Issue
Identification of Modulators of the C. elegans Aryl Hydrocarbon Receptor and Characterization of Transcriptomic and Metabolic AhR-1 Profiles
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress

by
Giulia Matacchione
1,*,
Debora Valli
1,
Andrea Silvestrini
1,
Angelica Giuliani
1,
Jacopo Sabbatinelli
1,
Chiara Giordani
1,
Sofia Coppari
2,
Maria Rita Rippo
1,
Maria Cristina Albertini
2,† and
Fabiola Olivieri
1,3,†
1
Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica Delle Marche, 60126 Ancona, Italy
2
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
3
Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, 60127 Ancona, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2022, 11(6), 1037; https://doi.org/10.3390/antiox11061037
Submission received: 28 April 2022 / Revised: 18 May 2022 / Accepted: 19 May 2022 / Published: 24 May 2022
(This article belongs to the Special Issue The 10th Anniversary of Antioxidants: Past, Present and Future)

Abstract

Chronic hyperglycemia, the diagnostic biomarker of Type 2 Diabetes Mellitus (T2DM), is a condition that fosters oxidative stress and proinflammatory signals, both involved in the promotion of cellular senescence. Senescent cells acquire a proinflammatory secretory phenotype, called SASP, exacerbating and perpetuating the detrimental effects of hyperglycemia. Bioactive compounds can exert antioxidant and anti-inflammatory properties. However, the synergistic anti-inflammatory and antioxidant effects of the most extensively investigated natural compounds have not been confirmed yet in senescent cells and in hyperglycemic conditions. Here, we exposed young and replicative senescent HUVEC (yHUVEC and sHUVEC) to a high-glucose (HG) condition (45 mM) and treated them with Polydatin (POL), Curcumin (CUR) and Quercetin (QRC), alone or in combination (MIX), to mirror the anti-inflammatory component OxiDefTM contained in the novel nutraceutical GlicefenTM (Mivell, Italy). In both yHUVEC and sHUVEC, the MIX significantly decreased the expression levels of inflammatory markers, such as MCP-1, IL-1β and IL-8, and ROS production. Importantly, in sHUVEC, a synergistic effect of the MIX was observed, suggesting its senomorphic activity. Moreover, the MIX was able to reduce the expression level of RAGE, a receptor involved in the activation of proinflammatory signaling. Overall, our data suggest that the consumption of nutraceuticals containing different natural compounds could be an adjuvant supplement to counteract proinflammatory and pro-oxidative signals induced by both hyperglycemic and senescence conditions.
Keywords: hyperglycemia; natural compounds; T2DM; aging; oxidative stress hyperglycemia; natural compounds; T2DM; aging; oxidative stress

Share and Cite

MDPI and ACS Style

Matacchione, G.; Valli, D.; Silvestrini, A.; Giuliani, A.; Sabbatinelli, J.; Giordani, C.; Coppari, S.; Rippo, M.R.; Albertini, M.C.; Olivieri, F. Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress. Antioxidants 2022, 11, 1037. https://doi.org/10.3390/antiox11061037

AMA Style

Matacchione G, Valli D, Silvestrini A, Giuliani A, Sabbatinelli J, Giordani C, Coppari S, Rippo MR, Albertini MC, Olivieri F. Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress. Antioxidants. 2022; 11(6):1037. https://doi.org/10.3390/antiox11061037

Chicago/Turabian Style

Matacchione, Giulia, Debora Valli, Andrea Silvestrini, Angelica Giuliani, Jacopo Sabbatinelli, Chiara Giordani, Sofia Coppari, Maria Rita Rippo, Maria Cristina Albertini, and Fabiola Olivieri. 2022. "Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress" Antioxidants 11, no. 6: 1037. https://doi.org/10.3390/antiox11061037

APA Style

Matacchione, G., Valli, D., Silvestrini, A., Giuliani, A., Sabbatinelli, J., Giordani, C., Coppari, S., Rippo, M. R., Albertini, M. C., & Olivieri, F. (2022). Curcumin, Polydatin and Quercetin Synergistic Activity Protects from High-Glucose-Induced Inflammation and Oxidative Stress. Antioxidants, 11(6), 1037. https://doi.org/10.3390/antiox11061037

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop