Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin

Corbacho-Alonso, Nerea; Rodríguez-Sánchez, Elena; Sastre-Oliva, Tamara; Mercado-García, Elisa; Perales-Sánchez, Ines; Juarez-Alia, Cristina; López-Almodovar, Luis F.; Padial, Luis R.; Tejerina, Teresa; Mourino-Alvarez, Laura; Ruiz-Hurtado, Gema; Barderas, María G.

doi:10.3390/antiox12051024

Open AccessArticle

Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin

by

Nerea Corbacho-Alonso

^1,2,†

,

Elena Rodríguez-Sánchez

^3,†

,

Tamara Sastre-Oliva

^1,2

,

Elisa Mercado-García

³,

Ines Perales-Sánchez

^1,2,

Cristina Juarez-Alia

^1,2,

Luis F. López-Almodovar

⁴,

Luis R. Padial

⁵

,

Teresa Tejerina

⁶,

Laura Mourino-Alvarez

^1,2,‡,

Gema Ruiz-Hurtado

^3,7,*,‡

and

María G. Barderas

^1,2,*,‡

¹

Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, SESCAM (Servicio de Salud de Castilla-La Mancha), 45071 Toledo, Spain

²

Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), 45071 Toledo, Spain

³

Cardiorenal Translational Laboratory, Instituto de Investigación Imas12, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain

⁴

Cardiac Surgery, Hospital General Universitario de Toledo, SESCAM, 45007 Toledo, Spain

⁵

Department of Cardiology, Hospital General Universitario de Toledo, SESCAM, 45007 Toledo, Spain

⁶

Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain

⁷

Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, CIBER-CV Hospital Universitario 12 de Octubre, 28041 Madrid, Spain

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

^‡

These authors contributed equally to this work.

Antioxidants 2023, 12(5), 1024; https://doi.org/10.3390/antiox12051024

Submission received: 2 March 2023 / Revised: 25 April 2023 / Accepted: 26 April 2023 / Published: 28 April 2023

(This article belongs to the Special Issue Redox Homeostasis and Antioxidant Strategies in the Pathophysiology)

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Abstract

Calcific aortic stenosis (CAS) and type 2 diabetes mellitus (T2DM) are related and often concomitant pathologies, accompanied by common comorbidities such as hypertension or dyslipidemia. Oxidative stress is one of the mechanisms that trigger CAS, and it can drive the vascular complications in T2DM. Metformin can inhibit oxidative stress, yet its effects have not been studied in the context of CAS. Here, we assessed the global oxidative status in plasma from patients with CAS, both alone and with T2DM (and under treatment with metformin), using multimarker scores of systemic oxidative damage (OxyScore) and antioxidant defense (AntioxyScore). The OxyScore was determined by measuring carbonyls, oxidized LDL (oxLDL), 8-hydroxy-20-deoxyguanosine (8-OHdG), and xanthine oxidase (XOD) activity. In contrast, the AntioxyScore was determined through the catalase (CAT) and superoxide dismutase (SOD) activity, as well as the total antioxidant capacity (TAC). Patients with CAS displayed enhanced oxidative stress compared to control subjects, probably exceeding their antioxidant capacity. Interestingly, patients with CAS and T2DM displayed less oxidative stress, possibly due to the benefits of their pharmacological therapy (metformin). Thus, reducing oxidative stress or enhancing antioxidant capacity through specific therapies could be a good strategy to manage CAS, focusing on personalized medicine.

Keywords: calcific aortic stenosis; diabetes mellitus; oxidative stress; antioxidant defense; metformin

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MDPI and ACS Style

Corbacho-Alonso, N.; Rodríguez-Sánchez, E.; Sastre-Oliva, T.; Mercado-García, E.; Perales-Sánchez, I.; Juarez-Alia, C.; López-Almodovar, L.F.; Padial, L.R.; Tejerina, T.; Mourino-Alvarez, L.; et al. Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin. Antioxidants 2023, 12, 1024. https://doi.org/10.3390/antiox12051024

AMA Style

Corbacho-Alonso N, Rodríguez-Sánchez E, Sastre-Oliva T, Mercado-García E, Perales-Sánchez I, Juarez-Alia C, López-Almodovar LF, Padial LR, Tejerina T, Mourino-Alvarez L, et al. Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin. Antioxidants. 2023; 12(5):1024. https://doi.org/10.3390/antiox12051024

Chicago/Turabian Style

Corbacho-Alonso, Nerea, Elena Rodríguez-Sánchez, Tamara Sastre-Oliva, Elisa Mercado-García, Ines Perales-Sánchez, Cristina Juarez-Alia, Luis F. López-Almodovar, Luis R. Padial, Teresa Tejerina, Laura Mourino-Alvarez, and et al. 2023. "Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin" Antioxidants 12, no. 5: 1024. https://doi.org/10.3390/antiox12051024

APA Style

Corbacho-Alonso, N., Rodríguez-Sánchez, E., Sastre-Oliva, T., Mercado-García, E., Perales-Sánchez, I., Juarez-Alia, C., López-Almodovar, L. F., Padial, L. R., Tejerina, T., Mourino-Alvarez, L., Ruiz-Hurtado, G., & Barderas, M. G. (2023). Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin. Antioxidants, 12(5), 1024. https://doi.org/10.3390/antiox12051024

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Global Oxidative Status Is Linked to Calcific Aortic Stenosis: The Differences Due to Diabetes Mellitus and the Effects of Metformin

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