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Antioxidants
Volume 12
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10.3390/antiox12061290
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Review

Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases

by
Ayauly Duisenbek
1,2,
Gabriela C. Lopez-Armas
3,
Miguel Pérez
4,
María D. Avilés Pérez
5,
José Miguel Aguilar Benitez
4,
Víctor Roger Pereira Pérez
2,
Juan Gorts Ortega
2,
Arailym Yessenbekova
1,2,
Nurzhanyat Ablaikhanova
1,
Germaine Escames
6,7,8,
Darío Acuña-Castroviejo
6,7,8 and
Iryna Rusanova
2,6,7,*
1
Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi Av. 71, Almaty 050040, Kazakhstan
2
Department of Biochemistry and Molecular Biology I, Faculty of Science, University of Granada, 18019 Granada, Spain
3
Departamento de Investigación y Extensión, Centro de Enseñanza Técnica Industrial, C. Nueva Escocia 1885, Guadalajara 44638, Mexico
4
Hospital de Alta Resolución de Alcalá la Real, 23680 Jaén, Spain
5
Endocrinology and Nutrition Unit, Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), University Hospital Clínico San Cecilio, 18016 Granada, Spain
6
Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERfes), Instituto de Investigación Biosanitaria de Granada (Ibs.GRANADA), San Cecilio University Hospital Clínico, 18016 Granada, Spain
7
Instituto de Biotecnología, Centro de Investigación Biomédica, Parque Tecnológico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain
8
Department of Physiology, Faculty of Medicine, University of Granada, 18016 Granada, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2023, 12(6), 1290; https://doi.org/10.3390/antiox12061290
Submission received: 13 May 2023 / Revised: 5 June 2023 / Accepted: 10 June 2023 / Published: 16 June 2023
(This article belongs to the Special Issue Genetics and Epigenetic Modifications on Metabolic Diseases Oxidative Related)
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Abstract

A common denominator of metabolic diseases, including type 2 diabetes Mellitus, dyslipidemia, and atherosclerosis, are elevated oxidative stress and chronic inflammation. These complex, multi-factorial diseases are caused by the detrimental interaction between the individual genetic background and multiple environmental stimuli. The cells, including the endothelial ones, acquire a preactivated phenotype and metabolic memory, exhibiting increased oxidative stress, inflammatory gene expression, endothelial vascular activation, and prothrombotic events, leading to vascular complications. There are different pathways involved in the pathogenesis of metabolic diseases, and increased knowledge suggests a role of the activation of the NF-kB pathway and NLRP3 inflammasome as key mediators of metabolic inflammation. Epigenetic-wide associated studies provide new insight into the role of microRNAs in the phenomenon of metabolic memory and the development consequences of vessel damage. In this review, we will focus on the microRNAs related to the control of anti-oxidative enzymes, as well as microRNAs related to the control of mitochondrial functions and inflammation. The objective is the search for new therapeutic targets to improve the functioning of mitochondria and reduce oxidative stress and inflammation, despite the acquired metabolic memory.
Keywords: metabolic diseases; circulating microRNA; oxidative stress; exosomes; epigenetic; inflammation; endothelial dysfunction metabolic diseases; circulating microRNA; oxidative stress; exosomes; epigenetic; inflammation; endothelial dysfunction

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MDPI and ACS Style

Duisenbek, A.; Lopez-Armas, G.C.; Pérez, M.; Avilés Pérez, M.D.; Aguilar Benitez, J.M.; Pereira Pérez, V.R.; Gorts Ortega, J.; Yessenbekova, A.; Ablaikhanova, N.; Escames, G.; et al. Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases. Antioxidants 2023, 12, 1290. https://doi.org/10.3390/antiox12061290

AMA Style

Duisenbek A, Lopez-Armas GC, Pérez M, Avilés Pérez MD, Aguilar Benitez JM, Pereira Pérez VR, Gorts Ortega J, Yessenbekova A, Ablaikhanova N, Escames G, et al. Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases. Antioxidants. 2023; 12(6):1290. https://doi.org/10.3390/antiox12061290

Chicago/Turabian Style

Duisenbek, Ayauly, Gabriela C. Lopez-Armas, Miguel Pérez, María D. Avilés Pérez, José Miguel Aguilar Benitez, Víctor Roger Pereira Pérez, Juan Gorts Ortega, Arailym Yessenbekova, Nurzhanyat Ablaikhanova, Germaine Escames, and et al. 2023. "Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases" Antioxidants 12, no. 6: 1290. https://doi.org/10.3390/antiox12061290

APA Style

Duisenbek, A., Lopez-Armas, G. C., Pérez, M., Avilés Pérez, M. D., Aguilar Benitez, J. M., Pereira Pérez, V. R., Gorts Ortega, J., Yessenbekova, A., Ablaikhanova, N., Escames, G., Acuña-Castroviejo, D., & Rusanova, I. (2023). Insights into the Role of Plasmatic and Exosomal microRNAs in Oxidative Stress-Related Metabolic Diseases. Antioxidants, 12(6), 1290. https://doi.org/10.3390/antiox12061290

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