Next Article in Journal
Variations in Proline Content, Polyamine Profiles, and Antioxidant Capacities among Different Provenances of European Beech (Fagus sylvatica L.)
Next Article in Special Issue
Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia
Previous Article in Journal
Enrichment of Whole-Grain Breads with Food-Grade Extracted Apple Pomace Bioactives Enhanced Their Anti-Inflammatory, Antithrombotic and Anti-Oxidant Functional Properties
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antioxidants
Volume 13
Issue 2
10.3390/antiox13020226
antioxidants-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models

by
You-Lin Tain
1,2,3 and
Chien-Ning Hsu
4,5,*
1
Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
2
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
3
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan
5
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Author to whom correspondence should be addressed.
Antioxidants 2024, 13(2), 226; https://doi.org/10.3390/antiox13020226
Submission received: 9 January 2024 / Revised: 6 February 2024 / Accepted: 9 February 2024 / Published: 12 February 2024
(This article belongs to the Special Issue The Role of Antioxidants in Pregnant Women’s and Children’s Health—2nd Edition)
Browse Figures
Review Reports Versions Notes

Abstract

:
Cardiovascular–kidney–metabolic (CKM) syndrome has emerged as a major global public health concern, posing a substantial threat to human health. Early-life exposure to oxidative stress may heighten vulnerability to the developmental programming of adult diseases, encompassing various aspects of CKM syndrome. Conversely, the initiation of adverse programming processes can potentially be thwarted through early-life antioxidant interventions. Melatonin, originally recognized for its antioxidant properties, is an endogenous hormone with diverse biological functions. While melatonin has demonstrated benefits in addressing disorders linked to oxidative stress, there has been comparatively less focus on investigating its reprogramming effects on CKM syndrome. This review consolidates the current knowledge on the role of oxidative stress during pregnancy and lactation in inducing CKM traits in offspring, emphasizing the underlying mechanisms. The multifaceted role of melatonin in regulating oxidative stress, mediating fetal programming, and preventing adverse outcomes in offspring positions it as a promising reprogramming strategy. Currently, there is a lack of sufficient information in humans, and the available evidence primarily originates from animal studies. This opens up new avenues for novel preventive intervention in CKM syndrome.

1. Introduction

Increasing recognition of the pathological interconnections among metabolic risk factors like obesity and diabetes, chronic kidney disease (CKD), and cardiovascular disease (CVD) has given rise to the conceptualization of cardiovascular–kidney–metabolic (CKM) syndrome [1]. For the first time, the 2023 Scientific Statement from the American Heart Association defines CKM syndrome as a systemic disorder marked by pathophysiological interactions among metabolic risk factors, CKD, and the cardiovascular system. This interaction results in multiorgan dysfunction and a heightened risk of adverse cardiovascular and renal outcomes [1]. CKM syndrome is classified into four distinct stages, ranging from stage 0 to stage 4. These stages likely represent varying degrees of progression and severity within the complex spectrum of this disease. Various key components manifest at different stages, contributing to the varied degrees of progression and severity within the complex spectrum of CKM syndrome.
While the global disease burden of individual metabolic diseases, CKD, and CVD is widely recognized [2,3,4,5], the complex and mutually reinforcing detrimental relationships among them remain largely unclear. Epidemiological studies suggest a multidirectional connection among these conditions. For instance, individuals with CKD face an elevated risk of developing CVD [6]. Comorbidities associated with CKD, such as obesity, diabetes, and hypertension, constitute significant components of metabolic syndrome [7]. Additionally, cardiorenal syndrome is a recognized condition in which dysfunction of either the heart or kidneys can impair function in the other organs [8]. Furthermore, metabolic syndrome, a cluster of conditions, collectively amplifies the susceptibility to CVD [9]. Recently, the concept of metabolic syndrome has evolved into one of cardiometabolic syndrome, encompassing characteristics of metabolic syndrome along with traditional CVD factors [10]. Consequently, it is plausible that CVD, CKD, and metabolic diseases may interact at the pathophysiological level, leading to clinical overlap between these health conditions [11].
Approximately 40% of adults in the United States are estimated to be affected by CKM syndrome [12]. Given that CKM syndrome impacts nearly all organ systems, there is a substantial global burden of compromised cardiovascular–kidney–metabolic health. Although managing the entire syndrome holistically, rather than focusing on individual diseases, is recommended for optimal care [12], a comprehensive therapeutic guideline is still pending. It is noteworthy that placing emphasis on early prevention has the potential to alleviate the burden associated with CKM syndrome. Recognizing the interplay between CKM diseases is crucial for adopting a more holistic approach to CKM care, moving beyond the isolated treatment of individual conditions. This broader perspective holds promise for enhancing global health outcomes in the future.
An expanding body of literature indicates that unfavorable environmental conditions during pregnancy and early infancy may increase the susceptibility to adult diseases [13], encompassing all facets of CKM syndrome. Termed the Developmental Origins of Health and Disease (DOHaD), this theory posits that a developing fetus responds to environmental challenges by making structural and functional adaptations, thereby increasing the risk of developing chronic diseases later in life [14]. Although our understanding of the pathophysiological mechanisms of DOHaD remains incomplete, oxidative stress plays a role in the etiology of many DOHaD-related diseases [15].
Oxidative stress arises from an imbalance between the production of harmful reactive oxygen/nitrogen species (ROS/RNS) and the antioxidant system’s ability to detoxify them [16]. Both human and experimental studies provide evidence supporting the involvement of oxidative stress in various aspects of CKM syndrome [17,18,19] (Figure 1). Conversely, the administration of antioxidants has been reported to ameliorate CKM syndrome [20,21,22]. Early-life interventions, referred to as reprogramming, have the potential to reverse detrimental programming processes and alleviate the onset of adult diseases [23]. The use of antioxidants during pregnancy and lactation has demonstrated benefits as a reprogramming strategy for preventing numerous adult diseases [24].
Melatonin, primarily secreted by the pineal gland during nighttime, serves as a versatile hormone [25]. Alongside its metabolites, melatonin exhibits antioxidant properties, positioning this molecule as an intrinsic safeguard against various disorders associated with oxidative stress [26,27]. In recent times, melatonin has found applications in the treatment of pregnant women and various pediatric conditions [28,29,30]. In this context, we will delve into the existing knowledge regarding the links among melatonin, maternal oxidative stress, and the development of offspring CKM syndrome.
A comprehensive literature review was conducted by querying the databases Embase, MEDLINE, and the Cochrane Library to identify studies published in English. The search utilized relevant keywords pertaining to melatonin, oxidative stress, DOHaD, and CKM syndrome. The employed search terms included “metabolic syndrome”, “hypertension”, “dyslipidemia”, “hyperlipidemia”, “obesity”, “diabetes”, “insulin resistance”, “hyperglycemia”, “liver steatosis”, “chronic kidney disease”, “cardiovascular disease”, “atherosclerosis”, “heart failure”, “cardiorenal syndrome”, “developmental programming”, “DOHaD”, “ free radicals”, “offspring”, “progeny”, “mother”, “prenatal”, “nitric oxide”, “oxidative stress”, “pregnancy”, “reprogramming”, “reactive oxygen species”, “reactive nitrogen species”, and “melatonin”. Additionally, we scrutinized the reference lists of articles to identify any additional references relevant to this review. The search concluded on 30 November 2023.

2. Oxidative Stress

2.1. ROS, RNS, NO, and Antioxidants

Oxidative stress results from an imbalance between prooxidants and antioxidants [16]. The detrimental effects of oxygen/nitrogen free radicals and non-radical reactive species, collectively referred to as ROS/RNS, can lead to potential biological oxidative damage [31]. Cellular nitric oxide (NO) can interact with ROS, giving rise to various RNS implicated in nitrosative damage. Among the crucial reactive species are the superoxide anion radical (O2−), hydroxyl radical (OH), hydrogen peroxide (H2O2), and peroxynitrite (ONOO−). Major enzymatic sources of ROS include the electron transport chain complexes in mitochondria, NADPH oxidase (NOX), and xanthine oxidase (XO). Additionally, NO can be produced through three isoforms of NO synthase (NOS): neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS) [32]. Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively), inhibitors of NOS, have the potential to uncouple NOSs, leading to peroxynitrite generation. This not only diminishes NO production, but also intensifies oxidative stress [33].
Conversely, excessive ROS/RNS can be counteracted by antioxidant systems, encompassing enzymatic components such as superoxide dismutase (SOD) and non-enzymatic antioxidants like glutathione [34]. Throughout pregnancy, a delicate balance is established among ROS, RNS, and antioxidants, crucial for determining normal fetal growth and development.

2.2. Oxidative Stress during Pregnancy

Throughout pregnancy, the physiological generation of ROS plays a crucial role in various developmental processes, encompassing oocyte maturation [35], embryo implantation [36], placental differentiation [37], and fetal development [38]. The fetal oxygen requirement varies across different trimesters, with low levels during the initial trimester and a subsequent increase in response to rapid fetal weight gain and the formation of fetal–placental circulation [39].
Compromised pregnancies, marked by maternal illnesses and adverse conditions, are associated with oxidative stress. These conditions include preeclampsia, maternal smoking, obesity, diabetes, placental insufficiency, preterm labor, and intrauterine growth retardation (IUGR) [40]. For instance, current evidence suggests that the pathogenesis of preeclampsia involves increased lipid peroxidation products, elevated nitrotyrosine immunostaining, and reduced antioxidant enzyme activities [41]. Another significant indicator is ADMA. There is growing support for the association of high ADMA levels with conditions such as preeclampsia [42], gestational diabetes [43], IUGR, and placental insufficiency [44]. Furthermore, studies have reported elevated levels of ROS or oxidative stress by-products and decreased antioxidant levels in cases of preterm labor [45].

2.3. Animal Models of Oxidative-Stress-Associated Offspring CKM Syndrome

Accumulating evidence underscores the pathogenic interplay between oxidative stress and various facets of CKM syndrome, including obesity [46], kidney disease [47], CVD [48], diabetes [49], nonalcoholic fatty liver disease (NAFLD) [50], and hypertension [51]. However, there is a lack of information regarding oxidative stress during human pregnancy that may be associated with offspring CKM syndrome in childhood or adulthood.
Several recent animal studies emphasize the significance of early-life oxidative stress concerning specific components of CKM syndrome, such as kidney disease or hypertension, and these have been comprehensively reviewed elsewhere [24,52]. However, a notable gap exists in studies directly addressing the impact of early-life oxidative stress on all CKM traits in adult offspring. Therefore, Table 1 predominantly compiles findings from animal models exhibiting at least two components of CKM syndrome in offspring that are associated with oxidative stress [53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100]. Moreover, this review focuses on rat models to facilitate relevant comparisons of major CKM syndrome components throughout the lifespan.
Considering that one rat month is roughly equivalent to three human years [101], Table 1 provides the age of offspring outcomes, ranging from 12 to 52 weeks, in rats. This timeline corresponds to humans from young adulthood to middle age.
Imbalances in maternal nutrition play a significant role in inducing oxidative stress-related CKM syndrome in adult offspring. Various nutritional insults contribute to this, including calorie restriction [53,54,55], protein restriction [56,57,58], maternal high-fructose diet [59,60,61,62,63], and maternal high-fat diet [64,65,66,67,68]. Additionally, maternal illnesses and pregnancy complications can disrupt the oxidative balance, leading to the manifestation of CKM syndrome in offspring. For instance, maternal diabetes has been identified as a contributor to oxidative stress, linked to obesity, insulin resistance, hypertension, dyslipidemia, and kidney disease in adult offspring [69,70,71].
Several early-life risks have been associated with the development of CKM syndrome in offspring, including uteroplacental insufficiency [72,73,74,75], maternal chronodisruption [76,77,78], maternal stress [79,80,81,82], maternal chronic kidney disease (CKD) [83,84], nicotine exposure [85,86,87,88], and ethanol exposure [89,90,91]. Furthermore, offspring CKM syndrome can be programmed by dams exposed to environmental chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [92,93], bisphenol A (BPA) [94,95,96], and di-n-butyl phthalate (DEHP) [99,100,101].

2.4. Mechanisms Underlying Oxidative Stress in CKM Syndrome

In developmental-origin-related CKM syndrome, a comprehensive array of oxidative stress mechanisms has been observed, encompassing an increased expression of ROS-generating enzymes, heightened ROS production, diminished antioxidant bioavailability, elevated peroxynitrite formation, an impaired ADMA–NO pathway, and augmented oxidative damage.
The elevated expression of ROS-generating enzymes and increased ROS production are linked to various CKM syndrome models, including those induced by a maternal high-fructose diet [62], uteroplacental insufficiency [75], maternal stress [82], nicotine exposure [85], and ethanol exposure [90]. Several CKM syndrome models also demonstrate reduced antioxidant bioavailability, such as decreased levels of glutathione [57], and compromised antioxidant enzyme activities [80], including SOD, glutathione peroxidase 1, and catalase.
The formation of 3-nitrotyrosine (3-NT), indicative of peroxynitrite-mediated protein modification [102], is correlated with CKM syndrome in offspring programmed by maternal caloric restriction [54], maternal low-protein diet [58], and prenatal nicotine exposure [87]. Additionally, various biomarkers reflecting oxidative damage to proteins, lipids, and DNA have been assessed in CKM syndrome animal models. These include malondialdehyde (MDA) [62], thiobarbituric-acid-reactive substances (TBARS) [70], F2-isoprostanes [75], 4-hydroxynonenal (4-NHE) [87], and 8-hydroxydeoxyguanosine (8-OHdG) [83,92].
Another contributing mechanism of oxidative stress in the pathogenesis of programmed CKM syndrome is the impaired ADMA–NO pathway. High levels of ADMA, inhibiting NO production and thereby impairing endothelial function, have been associated with the development of various CKM syndrome components. This is evident in models of caloric restriction [53], maternal diabetes [69], maternal stress [79], and perinatal bisphenol A (BPA) exposure [94].

2.5. Perinatal Use of Antioxidants as a Reprogramming Strategy

Given the pivotal role of early-life oxidative stress in influencing adverse outcomes in offspring, there has been a notable interest in exploring the perinatal use of antioxidants as a potential preventive strategy for adult diseases [15,24,52,103]. However, conclusive evidence of confirmed benefits from antioxidant supplementation, particularly in pregnant or lactating women, remains elusive in the majority of human studies [104]. The conflicting findings and challenges in interpreting clinical evidence may stem from factors such as the study population, the type of antioxidant, supplement timing and dosage, and the specific disease status deemed suitable for treatment. Hence, it is crucial to conduct additional research aimed at pinpointing the precise developmental stage (such as gestation or lactation) and unraveling organ-specific redox-sensitive signaling pathways associated with various maternal insults that contribute to CKM programming in animal models. This groundwork is essential before translating the findings into clinical applications.
Antioxidants can be classified as natural or synthetic [105]. Examples of natural antioxidants include vitamins A, C, and E, glutathione, polyphenols, carotenoids, and melatonin [106]. Although many natural antioxidants are widely used in humans [104], their benefits in pregnant and lactating women remain inconclusive.
Melatonin, a multifunctional hormone, is implicated in pregnancy and fetal development [107]. Research on melatonin has highlighted its crucial role in antioxidant defense against oxidative damage [26]. Notably, the utilization of melatonin during the perinatal period has been suggested as a reprogramming strategy to mitigate the risk of various adult diseases associated with DOHaD [108]. This summary outlines the current evidence supporting the perinatal use of melatonin to protect against offspring CKM syndrome (Figure 2).

3. Melatonin

3.1. Effects of Melatonin

Melatonin, initially identified in the bovine pineal gland [109], is predominantly synthesized by pinealocytes using tryptophan as a precursor [110]. While the pineal gland is a primary source, melatonin is also produced in various organs such as the retina, skin, gastrointestinal tract, and bone marrow [25]. The metabolism of melatonin occurs primarily in the liver and kidneys, with its primary urinary metabolite being 6-sulfatoxymelatonin [111].
Melatonin exerts its actions through binding to melatonin receptor-1 (MT1) and -2 (MT2), both of which are G-protein-coupled receptors widely distributed throughout the body [112]. Although there is some controversy regarding retinoid acid receptor (ROR) as a potential nuclear receptor for melatonin [113], the evidence remains inconclusive [114]. Melatonin also exhibits receptor-independent effects, such as activating cytoprotective pathways and functioning as a broad-spectrum antioxidant, possibly through its metabolites [111].
The physiological functions of melatonin are diverse and include the regulation of circadian rhythms, control of blood pressure and autonomic cardiovascular regulation, modulation of the immune system, regulation of energy expenditure and body mass, and vital roles in normal pregnancy and fetal development [25,26,115]. The principal mechanisms underlying melatonin’s antioxidant properties involve scavenging ROS/RNS, promoting the expression of antioxidant enzymes (e.g., SOD and glutathione reductase), and increasing the availability of NO.

3.2. Melatonin in Pregnancy and Fetal Development

Melatonin assumes a crucial role in various stages of reproductive processes, encompassing ovulation, fertilization, embryo implantation, and acting as a regulator during pregnancy [116]. In pregnant women, nighttime blood melatonin concentrations are higher than those in their non-pregnant counterparts, peaking at term and returning to physiological levels post-delivery [116]. Maternal melatonin easily traverses the placenta, offering photoperiodic cues to the developing fetus [117]. Beyond the pineal gland, the placenta can independently generate melatonin in a circadian-independent manner [118]. This placental melatonin system plays a pivotal role in scavenging free radicals, thereby attenuating oxidative damage in compromised pregnancies [119]. Experimental evidence supports melatonin’s involvement in ensuring adequate placental perfusion, preventing vascular damage, local inflammation, and oxidative stress [116]. Conversely, a deficiency in maternal melatonin disrupts circadian rhythms, compromises organogenesis, and contributes to IUGR in adult rat offspring [119,120]. Additionally, melatonin exerts biological influence in timing the onset of spontaneous labor and the efficacy of uterine contractions during labor [116]. These findings underscore the indispensable role of melatonin in ensuring normal pregnancy and fetal development. Figure 3 encapsulates the role of melatonin in pregnancy.

3.3. Perinatal Melatonin Use in Animal Models of CKM Syndrome of Developmental Origins

Due to its antioxidant effects, melatonin shows potential efficacy in treating disorders associated with CKM syndrome, including obesity [121], diabetes mellitus [121], metabolic syndrome [122], CKD [123], hypertension [124], and CVD [125]. Although certain human studies have investigated the administration of melatonin during pregnancy and lactation, comprehensive reviews highlight the absence of focused assessments on the long-term outcomes for offspring [126,127,128].
To address this gap, Table 2 provides a summary of studies documenting the protective effects of melatonin as a reprogramming strategy in rat models related to CKM syndrome of developmental origins [78,81,129,130,131,132,133,134,135,136,137,138,139]. The therapeutic duration is limited to the perinatal period before the onset of disease. Table 2 includes various early-life insults that lead to offspring CKM syndrome, and perinatal melatonin use has been shown to avert these effects. These insults encompass maternal chronodisruption [77,78], maternal hypertension [129,138], maternal caloric restriction [130], maternal NG-nitro-L-arginine-methyl ester (L-NAME) exposure [131], maternal high-methyl-donor diet [132], maternal high-fructose diet [133], maternal high-fat diet [134], perinatal glucocorticoid exposure [81,135,136,137], and maternal hypoxia [139]. Melatonin administration during pregnancy [129,139], lactation [137], or both periods [130,131,132,133,134,135,136] has demonstrated protective actions. Melatonin can be administered through injection [134,137] or via drinking water [78,129,130,131,132,133,134,135,136]. Table 2 showcases the protective effects of perinatal melatonin use in rat offspring aged from 3–27 weeks, corresponding to humans from childhood to young adulthood. In Table 2, the findings from animal studies suggest that melatonin doses within the range of 0.05–10 mg/kg/day demonstrate protective effects for rats.

3.4. Effects of Melatonin in Renal Programming

Accumulating evidence indicates that exposure to unfavorable environmental stimuli during kidney development raises the likelihood of CKD and hypertension in adulthood, primarily through renal programming [140,141]. Maternal melatonin deficiency has been implicated in causing renal programming, leading to offspring hypertension [142,143].
In a prior study, we scrutinized the renal transcriptome of male rat offspring born to dams receiving melatonin supplementation throughout pregnancy and lactation, covering the entire period of kidney development [144]. The results revealed 455, 230, and 132 differentially expressed genes in the offspring’s kidneys at 1, 12, and 16 weeks of age, respectively. Maternal melatonin therapy was found to upregulate several epigenetic regulators during kidney development, indicating its potential epigenetic effects [145]. Furthermore, melatonin administration influenced numerous biological pathways associated with kidney development.
Being a widely acknowledged antioxidant, melatonin therapy has exhibited protective effects against oxidative-stress-related renal programming in adult rat offspring. This was observed in models of dams receiving a low-caloric diet [130], antenatal L-NAME administration [131], dams fed with diet rich in methyl donor [132] or fructose [133], and antenatal glucocorticoid administration [135]. Perinatal melatonin use also proved beneficial in terms of renal programming, particularly in rebalancing the ADMA–NO pathway. In a maternal caloric restriction model [130], the protective mechanisms of melatonin against offspring hypertension were associated with a reduction in plasma ADMA, an increase in renal NO levels, and epigenetic changes in numerous genes within the offspring’s kidneys.

3.5. Effects of Melatonin in Cardiovascular Programming

While the cardiovascular benefits of antioxidants, in general, await definitive confirmation [136], melatonin has emerged as a potential reprogramming intervention against cardiovascular programming complexities associated with maternal hypoxia [139]. Adult rat offspring exposed to hypoxic pregnancy displayed cardiac wall thinning and heightened vasoconstrictor reactivity, conditions mitigated by maternal treatment with melatonin. The protective effect of melatonin was linked to an increase in the cardiac protein expression of eNOS [139].
It is noteworthy that melatonin’s cardioprotective attributes are also ascribed to its various antioxidant actions [146], including the inhibition of mitochondrial respiratory chain complex [147], the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) [148], and the suppression of inflammatory cytokine release [149]. However, these mechanisms have yet to be thoroughly examined in animal models of oxidative-stress-related cardiovascular programming. A prior study suggested the beneficial role of melatonin in CVD programming in offspring primed by maternal diabetes [150]. While cardiac function and structure were comparable between adult mice offspring born to diabetic and nondiabetic dams, the diabetic offspring exhibited increased infarct size, cardiac dysfunction, and myocardial apoptosis in response to myocardial ischemia/reperfusion, along with heightened oxidative stress. Notably, maternal melatonin supplementation improved myocardial ischemic tolerance in the diabetic offspring.

3.6. Effects of Melatonin in Metabolic Programming

As outlined in Table 2, maternal melatonin therapy has demonstrated favorable effects against metabolic-programming-induced insulin resistance [77], obesity [134], hyperglycemia [134], hyperlipidemia [134,137], diabetes [137], and liver steatosis [134,135,137]. In a maternal high-fat diet model, maternal melatonin therapy shielded adult rat offspring from obesity, hyperglycemia, hyperlipidemia, and liver steatosis, concurrently reducing hepatic oxidative stress [134]. Another study indicated that liver steatosis induced by prenatal dexamethasone administration could be averted through maternal melatonin supplementation [135].
Adipose tissues are known to produce pro-inflammatory cytokines and ROS, which play a decisive role in the development of obesity [151]. Melatonin has the potential to counteract the detrimental effects of obesity on perivascular adipose tissue, addressing issues such as excessive ROS production, diminished SOD activity, and reduced NO availability [152]. Also, melatonin could stimulate the Nrf2 signaling pathway to reduce lipopolysaccharide-induced ROS generation [153] and ameliorate H2O2-induced oxidative stress through the modulation of the extracellular-signal-regulated kinase (ERK)/Akt/nuclear factor κ (NF-κB) pathway [154]. By activating antioxidant enzymes related to glutathione metabolism, melatonin could protect tissues such as the pancreas, adipose tissue, and liver from oxidative stress [151,155], through which it fights obesity-related disorders.
Similarly, in corticosterone-programmed diabetic offspring rats, melatonin demonstrated the ability to prevent metabolic programming [137]. The corticosterone-programmed diabetic offspring exhibited hyperglycemia, hypoinsulinemia, hyperlipidemia, and liver steatosis, accompanied by increased lipid peroxidation and decreased levels of enzymatic antioxidants. However, treatment with melatonin effectively prevented both CKM-syndrome-related components and oxidative stress [137].

3.7. Pros and Cons

Although animal studies provide evidence supporting melatonin as a promising reprogramming strategy for preventing CKM syndrome, its efficacy is yet to be validated in human trials. While melatonin is classified as a dietary supplement in the United States, it is only available as a prescription drug in many countries [156].
Currently, oral melatonin supplementation in humans is considered to have a favorable safety profile, with typical doses ranging from 2 to 10 mg in various populations [30]. Experimental data have revealed that melatonin is effective as an antioxidant at high pharmacological doses. Notably, uncertainty surrounds the use, especially at high dosages, of melatonin by mothers during pregnancy and lactation. Clinical studies, thus far, do not recommend the use of melatonin in pregnant and lactating women [30].
In the rat models outlined in Table 2, melatonin administered at a dosage ranging from 0.05 to 10 mg/kg/day to dams demonstrates protective effects against CMK syndrome in their offspring. It is noteworthy that melatonin exhibits remarkable non-toxicity, with a high safety profile observed in rats. The lethal dose 50 for intraperitoneal melatonin injection in rats was determined to be 1168 mg/kg, while the oral administration of melatonin (tested up to 3200 mg/kg) could not be determined [157]. Calculating the human equivalent dose of melatonin for a 75 kg adult based on body surface area normalization from the doses used in various rat models yields a range of 0.6 to 120 mg [158]—approximately one order of magnitude higher than commonly employed doses in humans based on the experiments in Table 2 [159].
Despite these data, there remains a scarcity of information from clinical trials regarding the use and safety of melatonin in pregnant or breastfeeding women [128]. A phase I clinical trial involving 20 pregnant women with early-onset preeclampsia administered a daily total of 30 mg melatonin (in three 10 mg doses) and reported the safety of melatonin for both women and their fetuses, with no adverse events or reactions observed in mothers, fetuses, or neonates [160]. To the best of our knowledge, no trial results focusing on the safety or efficacy of melatonin during pregnancy and lactation specifically for offspring outcomes, especially related to CKM syndrome, have been published [161]. This review underscores the imperative need for well-powered clinical trials in this domain.
As reviewed elsewhere [29], melatonin has been investigated as a potential treatment for various neonatal conditions, encompassing periventricular leukomalacia [162], hypoxic–ischemic injury [163], respiratory distress syndrome [164], and sepsis [165]. Given the challenges of recruiting pregnant women for medical research, utilizing lactating women and their neonates as a reprogramming strategy presents a feasible starting point.
Another concern is that targeted oxidative stress therapy can potentially be harmful. Excessive antioxidant supplementation may shift oxidative stress to the opposite state, known as antioxidant stress [166,167]. Despite its antioxidant property, melatonin may exhibit prooxidant activity as a modulator of cellular redox status [168]. Additionally, healthy tissues not affected by oxidative stress damage may be non-specifically targeted by antioxidants. When melatonin circulates and reaches various organs, it may negatively affect healthy tissues by reducing their levels of ROS below physiologically normal limits. Given the importance of redox homeostasis for normal pregnancy and fetal development, melatonin supplementation as an antioxidant during pregnancy and breastfeeding should only be considered in cases of oxidative stress, not as a routine dietary supplement.
Melatonin operates through various mechanisms to exert its functions. The beneficial effects of perinatal melatonin therapy may be attributed to several mechanisms beyond antioxidants, which are known to interact with oxidative stress underlying CKM syndrome. However, these biological actions may also have negative consequences. In light of this, additional research is essential to determine whether any detrimental consequences emerge from the perinatal administration of melatonin to offspring.

4. Concluding Remarks

The ROS generated during fetal and perinatal stages have the potential to influence the long-term health of individuals, increasing their vulnerability to various adult diseases. The impact of oxidative stress extends to key organs such as the kidneys, heart, blood vessels, and metabolic control systems, eventually contributing to CKM syndrome. Despite this understanding, a significant gap remains in animal models that directly explore the consequences of early-life oxidative stress on all aspects of CKM traits in adult offspring. Variations in outcomes may be attributed to diverse environmental insults, the susceptibility of specific developmental windows, organ-specific responses to oxidative stress, or the timing of offspring assessments. Consequently, further research is imperative to comprehend the intricacies of redox-sensitive signaling in different organs, which are affected by various maternal-derived insults during pregnancy and the perinatal period, influencing CKM programming. This knowledge will aid in the development of targeted antioxidant strategies to mitigate the impact of these insults on disease manifestation.
Additionally, melatonin emerges as a potential reprogramming strategy for preventing CKM syndrome. As a well-established antioxidant, melatonin exerts beneficial effects on human health, characterized by a favorable safety profile. Although animal studies showcase the notable advantages of melatonin therapy in CKM programming, its efficacy still awaits validation through human investigations. The anticipation is that melatonin may find application in clinical settings, influencing the interplay between oxidative stress and CKM syndrome in the future.

Author Contributions

Conceptualization, Y.-L.T. and C.-N.H.; writing—original draft, Y.-L.T. and C.-N.H.; data curation, Y.-L.T. and C.-N.H.; funding acquisition, Y.-L.T. and C.-N.H.; writing—review and editing, Y.-L.T. and C.-N.H. All authors have read and agreed to the published version of the manuscript.

Funding

This study was funded by Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, under grants CMRPG8M0721, CORPG8N0091 and CORPG8L0551.

Data Availability Statement

Data are contained within the article.

Conflicts of Interest

The authors declare no conflicts of interest.

References

  1. Ndumele, C.E.; Rangaswami, J.; Chow, S.L.; Neeland, I.J.; Tuttle, K.R.; Khan, S.S.; Coresh, J.; Mathew, R.O.; Baker-Smith, C.M.; Carnethon, M.R.; et al. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory from the American Heart Association. Circulation 2023, 148, 1606–1635. [Google Scholar] [CrossRef]
  2. Lozano, R.; Naghavi, M.; Foreman, K.; Lim, S.; Shibuya, K.; Aboyans, V.; Abraham, J.; Adair, T.; Aggarwal, R.; Ahn, S.Y.; et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012, 380, 2095–2128. [Google Scholar] [CrossRef] [PubMed]
  3. Joseph, P.; Leong, D.; McKee, M.; Anand, S.S.; Schwalm, J.D.; Teo, K.; Mente, A.; Yusuf, S. Reducing the Global Burden of Cardiovascular Disease, Part 1: The Epidemiology and Risk Factors. Circ. Res. 2017, 121, 677–694. [Google Scholar] [CrossRef] [PubMed]
  4. Glassock, R.J.; Warnock, D.G.; Delanaye, P. The global burden of chronic kidney disease: Estimates, variability and pitfalls. Nat. Rev. Nephrol. 2017, 13, 104–114. [Google Scholar] [CrossRef] [PubMed]
  5. Noubiap, J.J.; Nansseu, J.R.; Lontchi-Yimagou, E.; Nkeck, J.R.; Nyaga, U.F.; Ngouo, A.T.; Tounouga, D.N.; Tianyi, F.L.; Foka, A.J.; Ndoadoumgue, A.L.; et al. Global, regional, and country estimates of metabolic syndrome burden in children and adolescents in 2020: A systematic review and modelling analysis. Lancet Child Adolesc. Health 2022, 6, 158–170. [Google Scholar] [CrossRef] [PubMed]
  6. Lim, Y.J.; Sidor, N.A.; Tonial, N.C.; Che, A.; Urquhart, B.L. Uremic Toxins in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Mechanisms and Therapeutic Targets. Toxins 2021, 13, 142. [Google Scholar] [CrossRef] [PubMed]
  7. Scurt, F.G.; Ganz, M.J.; Herzog, C.; Bose, K.; Mertens, P.R.; Chatzikyrkou, C. Association of metabolic syndrome and chronic kidney disease. Obes. Rev. 2024, 25, e13649. [Google Scholar] [CrossRef] [PubMed]
  8. Ronco, C.; Bellasi, A.; Di Lullo, L. Cardiorenal Syndrome: An Overview. Adv. Chronic Kidney Dis. 2018, 25, 382–390. [Google Scholar] [CrossRef] [PubMed]
  9. Saklayen, M.G. The Global Epidemic of the Metabolic Syndrome. Curr. Hypertens. Rep. 2018, 20, 12. [Google Scholar] [CrossRef]
  10. Saxon, D.R.; Reiter-Brennan, C.; Blaha, M.J.; Eckel, R.H. Cardiometabolic Medicine: Development of a New Subspecialty. J. Clin. Endocrinol. Metab. 2020, 105, dgaa261. [Google Scholar] [CrossRef]
  11. Kadowaki, T.; Maegawa, H.; Watada, H.; Yabe, D.; Node, K.; Murohara, T.; Wada, J. Interconnection between cardiovascular, renal and metabolic disorders: A narrative review with a focus on Japan. Diabetes Obes. Metab. 2022, 24, 2283–2296. [Google Scholar] [CrossRef] [PubMed]
  12. Jaradat, J.H.; Nashwan, A.J. Cardiovascular-kidney-metabolic syndrome: Understanding the interconnections and the need for holistic intervention. J. Med. Surg. Public Health 2023, 1, 100028. [Google Scholar] [CrossRef]
  13. Hanson, M.; Gluckman, P. Developmental origins of noncommunicable disease: Population and public health implications. Am. J. Clin. Nutr. 2011, 94, 1754S–1758S. [Google Scholar] [CrossRef] [PubMed]
  14. Fleming, T.P.; Velazquez, M.A.; Eckert, J.J. Embryos, DOHaD and David Barker. J. Dev. Orig. Health Dis. 2015, 6, 377–383. [Google Scholar] [CrossRef] [PubMed]
  15. Rodríguez-Rodríguez, P.; Ramiro-Cortijo, D.; Reyes-Hernández, C.G.; López de Pablo, A.L.; González, M.C.; Arribas, S.M. Implication of Oxidative Stress in Fetal Programming of Cardiovascular Disease. Front. Physiol. 2018, 9, 602. [Google Scholar] [CrossRef] [PubMed]
  16. Sies, H. Oxidative stress: A concept in redox biology and medicine. Redox Biol. 2015, 4, 180–183. [Google Scholar] [CrossRef]
  17. Ravarotto, V.; Simioni, F.; Pagnin, E.; Davis, P.A.; Calò, L.A. Oxidative stress-chronic kidney disease-cardiovascular disease: A vicious circle. Life Sci. 2018, 210, 125–131. [Google Scholar] [CrossRef]
  18. Henriksen, E.J.; Diamond-Stanic, M.K.; Marchionne, E.M. Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic. Biol. Med. 2011, 51, 993–999. [Google Scholar] [CrossRef]
  19. Bondia-Pons, I.; Ryan, L.; Martinez, J.A. Oxidative stress and inflammation interactions in human obesity. J. Physiol. Biochem. 2012, 68, 701–711. [Google Scholar] [CrossRef]
  20. Abdali, D.; Samson, S.E.; Grover, A.K. How effective are antioxidant supplements in obesity and diabetes? Med. Princ. Pract. 2015, 24, 201–215. [Google Scholar] [CrossRef]
  21. Gregório, B.M.; De Souza, D.B.; de Morais Nascimento, F.A.; Pereira, L.M.; Fernandes-Santos, C. The potential role of antioxidants in metabolic syndrome. Curr. Pharm. Des. 2016, 22, 859–869. [Google Scholar] [CrossRef] [PubMed]
  22. Ahmad, K.A.; Yuan, D.Y.; Nawaz, W.; Ze, H.; Zhuo, C.X.; Talal, B.; Taleb, A.; Mais, E.; Qilong, D. Antioxidant therapy for management of oxidative stress induced hypertension. Free Radic. Res. 2017, 51, 428–438. [Google Scholar] [CrossRef] [PubMed]
  23. Paauw, N.D.; Van Rijn, B.B.; Lely, A.T.; Joles, J.A. Pregnancy as a critical window for blood pressure regulation in mother and child: Programming and reprogramming. Acta Physiol. 2016, 219, 241–259. [Google Scholar] [CrossRef] [PubMed]
  24. Diniz, M.S.; Magalhães, C.C.; Tocantins, C.; Grilo, L.F.; Teixeira, J.; Pereira, S.P. Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases. Nutrients 2023, 15, 4623. [Google Scholar] [CrossRef] [PubMed]
  25. Hardeland, R.; Pandi-Perumal, S.R.; Cardinali, D.P. Melatonin. Int. J. Biochem. Cell Biol. 2006, 38, 313–316. [Google Scholar] [CrossRef]
  26. Reiter, R.J.; Mayo, J.C.; Tan, D.X.; Sainz, R.M.; Alatorre-Jimenez, M.; Qin, L. Melatonin as an Antioxidant: Under Promises but over Delivers. J. Pineal Res. 2016, 61, 253–278. [Google Scholar] [CrossRef]
  27. Ghorbaninejad, P.; Sheikhhossein, F.; Djafari, F.; Tijani, A.J.; Mohammadpour, S.; Shab-Bidar, S. Effects of melatonin supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Horm. Mol. Biol. Clin. Investig. 2020, 41, 20200030. [Google Scholar] [CrossRef]
  28. Foster, J.R. Melatonin in Critically Ill Children. J. Pediatr. Intensive Care 2016, 5, 172–181. [Google Scholar] [CrossRef]
  29. Gitto, E.; Aversa, S.; Reiter, R.J.; Barberi, I.; Pellegrino, S. Update on the use of melatonin in pediatrics. J. Pineal Res. 2011, 50, 21–28. [Google Scholar] [CrossRef] [PubMed]
  30. Andersen, L.P.; Gögenur, I.; Rosenberg, J.; Reiter, R.J. The Safety of Melatonin in Humans. Clin. Drug Investig. 2016, 36, 169–175. [Google Scholar] [CrossRef] [PubMed]
  31. Dröge, W. Free Radicals in the Physiological Control of Cell Function. Physiol. Rev. 2002, 82, 47–95. [Google Scholar] [CrossRef] [PubMed]
  32. Kone, B.C. Nitric oxide synthesis in the kidney: Isoforms, biosynthesis, and functions in health. Semin. Nephrol. 2004, 24, 299–315. [Google Scholar] [CrossRef]
  33. Bełtowski, J.; Kedra, A. Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy. Pharmacol. Rep. 2006, 58, 159–178. [Google Scholar] [PubMed]
  34. Tain, Y.L.; Hsu, C.N. Oxidative Stress-Induced Hypertension of Developmental Origins: Preventive Aspects of Antioxidant Therapy. Antioxidants 2022, 11, 511. [Google Scholar] [CrossRef] [PubMed]
  35. Shkolnik, K.; Tadmor, A.; Ben-Dor, S.; Nevo, N.; Galiani, D.; Dekel, N. Reactive oxygen species are indispensable in ovulation. Proc. Natl. Acad. Sci. USA 2011, 108, 1462–1467. [Google Scholar] [CrossRef]
  36. Guérin, P.; El Mouatassim, S.; Ménézo, Y. Oxidative stress and protection against reactive oxygen species in the pre-implantation embryo and its surroundings. Hum. Reprod. Update 2001, 7, 175–189. [Google Scholar] [CrossRef]
  37. Myatt, L. Review: Reactive oxygen and nitrogen species and functional adaptation of the placenta. Placenta 2010, 31, S66–S69. [Google Scholar] [CrossRef]
  38. Thompson, L.P.; Al-Hasan, Y. Impact of oxidative stress in fetal programming. J. Pregnancy 2012, 2012, 582748. [Google Scholar] [CrossRef]
  39. Dennery, P.A. Oxidative stress in development: Nature or nurture? Free Radic. Biol. Med. 2010, 49, 1147–1151. [Google Scholar] [CrossRef]
  40. Carter, A.M. Placental oxygen consumption. Part, I. In vivo studies—A review. Placenta 2000, 21, S31–S37. [Google Scholar] [CrossRef]
  41. Chiarello, D.I.; Abad, C.; Rojas, D.; Toledo, F.; Vázquez, C.M.; Mate, A.; Sobrevia, L.; Marín, R. Oxidative stress: Normal pregnancy versus preeclampsia. Biochim. Biophys. Acta Mol. Basis Dis. 2020, 1866, 165354. [Google Scholar] [CrossRef]
  42. Pettersson, A.; Hedner, T.; Milsom, I. Increased circulating concentrations of asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, in preeclampsia. Acta Obstet. Gynecol. Scand. 1998, 77, 808–813. [Google Scholar] [CrossRef]
  43. Tiong, P.; Kosmider, L.; Lassi, Z.S.; Arstall, M.A.; Andraweera, P.H. Asymmetric dimethylarginine and gestational diabetes mellitus: A systematic review and meta-analysis. Endocrine 2023, 80, 283–291. [Google Scholar] [CrossRef] [PubMed]
  44. Tsikas, D.; Bollenbach, A.; Savvidou, M.D. Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: Circulating ADMA as an NO-independent indicator of fetal growth restriction? Amino Acids 2018, 50, 341–351. [Google Scholar] [CrossRef] [PubMed]
  45. Moore, T.A.; Ahmad, I.M.; Zimmerman, M.C. Oxidative Stress and Preterm Birth: An Integrative Review. Biol. Res. Nurs. 2018, 20, 497–512. [Google Scholar] [CrossRef]
  46. Manna, P.; Jain, S.K. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab. Syndr. Relat. Disord. 2015, 13, 423–444. [Google Scholar] [CrossRef] [PubMed]
  47. Daenen, K.; Andries, A.; Mekahli, D.; Van Schepdael, A.; Jouret, F.; Bammens, B. Oxidative stress in chronic kidney disease. Pediatr. Nephrol. 2019, 34, 975–991. [Google Scholar] [CrossRef] [PubMed]
  48. Sack, M.N.; Fyhrquist, F.Y.; Saijonmaa, O.J.; Fuster, V.; Kovacic, J.C. Basic Biology of Oxidative Stress and the Cardiovascular System: Part 1 of a 3-Part Series. J. Am. Coll. Cardiol. 2017, 70, 196–211. [Google Scholar] [CrossRef] [PubMed]
  49. Luc, K.; Schramm-Luc, A.; Guzik, T.J.; Mikolajczyk, T.P. Oxidative stress and inflammatory markers in prediabetes and diabetes. J. Physiol. Pharmacol. 2019, 70, 809–824. [Google Scholar]
  50. Chen, Z.; Tian, R.; She, Z.; Cai, J.; Li, H. Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. Free Radic. Biol. Med. 2020, 152, 116–141. [Google Scholar] [CrossRef]
  51. Griendling, K.K.; Camargo, L.L.; Rios, F.J.; Alves-Lopes, R.; Montezano, A.C.; Touyz, R.M. Oxidative Stress and Hypertension. Circ. Res. 2021, 128, 993–1020. [Google Scholar] [CrossRef]
  52. Nüsken, E.; Dötsch, J.; Weber, L.T.; Nüsken, K.D. Developmental Programming of Renal Function and Re-Programming Approaches. Front. Pediatr. 2018, 6, 36. [Google Scholar] [CrossRef]
  53. Tain, Y.L.; Hsieh, C.S.; Lin, I.C.; Chen, C.C.; Sheen, J.M.; Huang, L.T. Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: The impact of nitric oxide pathway. Nitric Oxide 2010, 23, 34–41. [Google Scholar] [CrossRef]
  54. Franco Mdo, C.; Ponzio, B.F.; Gomes, G.N.; Gil, F.Z.; Tostes, R.; Carvalho, M.H.; Fortes, Z.B. Micronutrient prenatal supplementation prevents the development of hypertension and vascular endothelial damage induced by intrauterine malnutrition. Life Sci. 2009, 85, 327–333. [Google Scholar] [CrossRef]
  55. Holemans, K.; Verhaeghe, J.; Dequeker, J.; Van Assche, F.A. Insulin sensitivity in adult female rats subjected to malnutrition during the perinatal period. J. Soc. Gynecol. Investig. 1996, 3, 71–77. [Google Scholar] [CrossRef]
  56. de Bem, G.F.; da Costa, C.A.; de Oliveira, P.R.; Cordeiro, V.S.; Santos, I.B.; de Carvalho, L.C.; Souza, M.A.; Ognibene, D.T.; Daleprane, J.B.; Sousa, P.J.; et al. Protective effect of Euterpe oleracea Mart (açaí) extract on programmed changes in the adult rat offspring caused by maternal protein restriction during pregnancy. J. Pharm. Pharmacol. 2014, 66, 1328–1338. [Google Scholar] [CrossRef]
  57. Cambonie, G.; Comte, B.; Yzydorczyk, C.; Ntimbane, T.; Germain, N.; Lê, N.L.; Pladys, P.; Gauthier, C.; Lahaie, I.; Abran, D.; et al. Antenatal antioxidant prevents adult hypertension, vascular dysfunction, and microvascular rarefaction associated with in utero exposure to a low-protein diet. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 292, R1236–R1245. [Google Scholar] [CrossRef] [PubMed]
  58. Ozanne, S.E.; Smith, G.D.; Tikerpae, J.; Hales, C.N. Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams. Am. J. Physiol. 1996, 270, E559–E564. [Google Scholar] [CrossRef] [PubMed]
  59. Ching, R.H.; Yeung, L.O.; Tse, I.M.; Sit, W.H.; Li, E.T. Supplementation of bitter melon to rats fed a high-fructose diet during gestation and lactation ameliorates fructose-induced dyslipidemia and hepatic oxidative stress in male offspring. J. Nutr. 2011, 141, 1664–1672. [Google Scholar] [CrossRef] [PubMed]
  60. Saad, A.F.; Dickerson, J.; Kechichian, T.B.; Yin, H.; Gamble, P.; Salazar, A.; Patrikeev, I.; Motamedi, M.; Saade, G.R.; Costantine, M.M. High-fructose diet in pregnancy leads to fetal programming of hypertension, insulin resistance, and obesity in adult offspring. Am. J. Obstet. Gynecol. 2016, 215, 378.e1–378.e6. [Google Scholar] [CrossRef] [PubMed]
  61. Hsu, C.N.; Lin, Y.J.; Hou, C.Y.; Tain, Y.L. Maternal Administration of Probiotic or Prebiotic Prevents Male Adult Rat Offspring against Developmental Programming of Hypertension Induced by High Fructose Consumption in Pregnancy and Lactation. Nutrients 2018, 10, 1229. [Google Scholar] [CrossRef]
  62. Chao, Y.M.; Wu, K.L.H.; Tsai, P.C.; Tain, Y.L.; Leu, S.; Lee, W.C.; Chan, J.Y.H. Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure. J. Biomed. Sci. 2020, 27, 68. [Google Scholar] [CrossRef]
  63. Tsai, P.C.; Chao, Y.M.; Chan, J.Y.H. Sympathetic activation of splenic T-lymphocytes in hypertension of adult offspring programmed by maternal high fructose exposure. Chin. J. Physiol. 2020, 63, 263–275. [Google Scholar] [CrossRef]
  64. Hsu, C.N.; Hou, C.Y.; Chang-Chien, G.P.; Lin, S.; Tain, Y.L. Maternal Garlic Oil Supplementation Prevents High-Fat Diet-Induced Hypertension in Adult Rat Offspring: Implications of H2S-Generating Pathway in the Gut and Kidneys. Mol. Nutr. Food Res. 2021, 65, e2001116. [Google Scholar] [CrossRef] [PubMed]
  65. Tsai, T.A.; Tsai, C.K.; Huang, L.T.; Sheen, J.M.; Tiao, M.M.; Tain, Y.L.; Chen, C.C.; Lin, I.C.; Lai, Y.J.; Tsai, C.C.; et al. Maternal Resveratrol Treatment Re-Programs and Maternal High-Fat Diet-Induced Retroperitoneal Adiposity in Male Offspring. Int. J. Environ. Res. Public Health 2020, 17, 2780. [Google Scholar] [CrossRef] [PubMed]
  66. Sheen, J.M.; Yu, H.R.; Tain, Y.L.; Tsai, W.L.; Tiao, M.M.; Lin, I.C.; Tsai, C.C.; Lin, Y.J.; Huang, L.T. Combined maternal and postnatal high-fat diet leads to metabolic syndrome and is effectively reversed by resveratrol: A multiple-organ study. Sci. Rep. 2018, 8, 5607. [Google Scholar] [CrossRef] [PubMed]
  67. Wu, Z.; Zhao, J.; Xu, H.; Lyv, Y.; Feng, X.; Fang, Y.; Xu, Y. Maternal quercetin administration during gestation and lactation decrease endoplasmic reticulum stress and related inflammation in the adult offspring of obese female rats. Eur. J. Nutr. 2014, 53, 1669–1683. [Google Scholar] [CrossRef] [PubMed]
  68. Tain, Y.L.; Lin, Y.J.; Sheen, J.M.; Yu, H.R.; Tiao, M.M.; Chen, C.C.; Tsai, C.C.; Huang, L.T.; Hsu, C.N. High Fat Diets Sex-Specifically Affect the Renal Transcriptome and Program Obesity, Kidney Injury, and Hypertension in the Offspring. Nutrients 2017, 9, 357. [Google Scholar] [CrossRef] [PubMed]
  69. Tain, Y.L.; Lee, W.C.; Hsu, C.N.; Lee, W.C.; Huang, L.T.; Lee, C.T.; Lin, C.Y. Asymmetric dimethylarginine is associated with developmental programming of adult kidney disease and hypertension in offspring of streptozotocin-treated mothers. PLoS ONE 2013, 8, e55420. [Google Scholar] [CrossRef]
  70. Oliveira, A.C.; Andreotti, S.; Chimin, P.; Sertié, R.A.; Farias Tda, S.; Torres-Leal, F.L.; de Proença, A.R.; Campaña, A.B.; D’Avila, L.S.; Oliveira, K.A.; et al. Neonatal streptozotocin-induced diabetes in mothers promotes metabolic programming of adipose tissue in male rat offspring. Life Sci. 2015, 136, 151–156. [Google Scholar] [CrossRef]
  71. Thaeomor, A.; Teangphuck, P.; Chaisakul, J.; Seanthaweesuk, S.; Somparn, N.; Roysommuti, S. Perinatal Taurine Supplementation Prevents Metabolic and Cardiovascular Effects of Maternal Diabetes in Adult Rat Offspring. Adv. Exp. Med. Biol. 2017, 975, 295–305. [Google Scholar] [PubMed]
  72. Walton, S.L.; Mazzuca, M.Q.; Tare, M.; Parkington, H.C.; Wlodek, M.E.; Moritz, K.M.; Gallo, L.A. Angiotensin receptor blockade in juvenile male rat offspring: Implications for long-term cardio-renal health. Pharmacol. Res. 2018, 134, 320–331. [Google Scholar] [CrossRef] [PubMed]
  73. Wlodek, M.E.; Westcott, K.; Siebel, A.L.; Owens, J.A.; Moritz, K.M. Growth restriction before or after birth reduces nephron number and increases blood pressure in male rats. Kidney Int. 2008, 74, 187–195. [Google Scholar] [CrossRef] [PubMed]
  74. Nüsken, K.D.; Dötsch, J.; Rauh, M.; Rascher, W.; Schneider, H. Uteroplacental insufficiency after bilateral uterine artery ligation in the rat: Impact on postnatal glucose and lipid metabolism and evidence for metabolic programming of the offspring by sham operation. Endocrinology 2008, 149, 1056–1063. [Google Scholar] [CrossRef] [PubMed]
  75. Ojeda, N.B.; Hennington, B.S.; Williamson, D.T.; Hill, M.L.; Betson, N.E.; Sartori-Valinotti, J.C.; Reckelhoff, J.F.; Royals, T.P.; Alexander, B.T. Oxidative stress contributes to sex differences in blood pressure in adult growth-restricted offspring. Hypertension 2012, 60, 114–122. [Google Scholar] [CrossRef]
  76. Varcoe, T.J.; Wight, N.; Voultsios, A.; Salkeld, M.D.; Kennaway, D.J. Chronic phase shifts of the photoperiod throughout pregnancy programs glucose intolerance and insulin resistance in the rat. PLoS ONE 2011, 6, e18504. [Google Scholar] [CrossRef]
  77. Ferreira, D.S.; Amaral, F.G.; Mesquita, C.C.; Barbosa, A.P.; Lellis-Santos, C.; Turati, A.O.; Santos, L.R.; Sollon, C.S.; Gomes, P.R.; Faria, J.A.; et al. Maternal melatonin programs the daily pattern of energy metabolism in adult offspring. PLoS ONE 2012, 7, e38795. [Google Scholar] [CrossRef]
  78. Tain, Y.L.; Lin, Y.J.; Chan, J.Y.H.; Lee, C.T.; Hsu, C.N. Maternal melatonin or agomelatine therapy prevents programmed hypertension in male offspring of mother exposed to continuous light. Biol. Reprod. 2017, 97, 636–643. [Google Scholar] [CrossRef]
  79. Tain, Y.L.; Sheen, J.M.; Chen, C.C.; Yu, H.R.; Tiao, M.M.; Kuo, H.C.; Huang, L.T. Maternal citrulline supplementation prevents prenatal dexamethasone-induced programmed hypertension. Free Radic. Res. 2014, 48, 580–586. [Google Scholar] [CrossRef] [PubMed]
  80. Tsai, C.C.; Tiao, M.M.; Sheen, J.M.; Huang, L.T.; Tain, Y.L.; Lin, I.C.; Lin, Y.J.; Lai, Y.J.; Chen, C.C.; Chang, K.A.; et al. Obesity programmed by prenatal dexamethasone and postnatal high-fat diet leads to distinct alterations in nutrition sensory signals and circadian-clock genes in visceral adipose tissue. Lipids Health Dis. 2019, 18, 19. [Google Scholar] [CrossRef] [PubMed]
  81. Tiao, M.M.; Huang, L.T.; Chen, C.J.; Sheen, J.M.; Tain, Y.L.; Chen, C.C.; Kuo, H.C.; Huang, Y.H.; Tang, K.S.; Chu, E.W.; et al. Melatonin in the regulation of liver steatosis following prenatal glucocorticoid exposure. BioMed Res. Int. 2014, 2014, 942172. [Google Scholar] [CrossRef] [PubMed]
  82. Lamothe, J.; Khurana, S.; Tharmalingam, S.; Williamson, C.; Byrne, C.J.; Lees, S.J.; Khaper, N.; Kumar, A.; Tai, T.C. Oxidative Stress Mediates the Fetal Programming of Hypertension by Glucocorticoids. Antioxidants 2021, 10, 531. [Google Scholar] [CrossRef] [PubMed]
  83. Hsu, C.N.; Yang, H.W.; Hou, C.Y.; Chang-Chien, G.P.; Lin, S.; Tain, Y.L. Maternal Adenine-Induced Chronic Kidney Disease Programs Hypertension in Adult Male Rat Offspring: Implications of Nitric Oxide and Gut Microbiome Derived Metabolites. Int. J. Mol. Sci. 2020, 21, 7237. [Google Scholar] [CrossRef] [PubMed]
  84. Hsu, C.N.; Hou, C.Y.; Chang-Chien, G.P.; Lin, S.; Tain, Y.L. Dietary Supplementation with Cysteine during Pregnancy Rescues Maternal Chronic Kidney Disease-Induced Hypertension in Male Rat Offspring: The Impact of Hydrogen Sulfide and Microbiota-Derived Tryptophan Metabolites. Antioxidants 2022, 11, 483. [Google Scholar] [CrossRef]
  85. Xiao, D.; Huang, X.; Yang, S.; Zhang, L. Antenatal nicotine induces heightened oxidative stress and vascular dysfunction in rat offspring. Br. J. Pharmacol. 2011, 164, 1400–1409. [Google Scholar] [CrossRef]
  86. Xiao, D.; Huang, X.; Li, Y.; Dasgupta, C.; Wang, L.; Zhang, L. Antenatal Antioxidant Prevents Nicotine-Mediated Hypertensive Response in Rat Adult Offspring. Biol. Reprod. 2015, 93, 66. [Google Scholar] [CrossRef]
  87. Conceição, E.P.; Peixoto-Silva, N.; Pinheiro, C.R.; Oliveira, E.; Moura, E.G.; Lisboa, P.C. Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring. Food Chem. Toxicol. 2015, 78, 52–59. [Google Scholar] [CrossRef] [PubMed]
  88. Chen, C.M.; Chou, H.C.; Huang, L.T. Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat offspring. Pediatr. Res. 2015, 77, 56–63. [Google Scholar] [CrossRef]
  89. Gray, S.P.; Denton, K.M.; Cullen-McEwen, L.; Bertram, J.F.; Moritz, K.M. Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny. J. Am. Soc. Nephrol. 2010, 21, 1891–1902. [Google Scholar] [CrossRef]
  90. Contreras, M.L.; de la Fuente-Ortega, E.; Vargas-Roberts, S.; Muñoz, D.C.; Goic, C.A.; Haeger, P.A. NADPH Oxidase Isoform 2 (NOX2) Is Involved in Drug Addiction Vulnerability in Progeny Developmentally Exposed to Ethanol. Front. Neurosci. 2017, 11, 338. [Google Scholar] [CrossRef]
  91. Nguyen, T.M.T.; Steane, S.E.; Moritz, K.M.; Akison, L.K. Prenatal alcohol exposure programmes offspring disease: Insulin resistance in adult males in a rat model of acute exposure. J. Physiol. 2019, 597, 5619–5637. [Google Scholar] [CrossRef]
  92. Aragon, A.C.; Kopf, P.G.; Campen, M.J.; Huwe, J.K.; Walker, M.K. In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: Effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology. Toxicol. Sci. 2008, 101, 321–330. [Google Scholar] [CrossRef] [PubMed]
  93. Hsu, C.N.; Hung, C.H.; Hou, C.Y.; Chang, C.I.; Tain, Y.L. Perinatal Resveratrol Therapy to Dioxin-Exposed Dams Prevents the Programming of Hypertension in Adult Rat Offspring. Antioxidants 2021, 10, 1393. [Google Scholar] [CrossRef] [PubMed]
  94. Hsu, C.N.; Lin, Y.J.; Tain, Y.L. Maternal exposure to bisphenol A combined with high-fat diet-induced programmed hypertension in adult male rat offspring: Effects of resveratrol. Int. J. Mol. Sci. 2019, 20, 4382. [Google Scholar] [CrossRef] [PubMed]
  95. Galyon, K.D.; Farshidi, F.; Han, G.; Ross, M.G.; Desai, M.; Jellyman, J.K. Maternal bisphenol A exposure alters rat offspring hepatic and skeletal muscle insulin signaling protein abundance. Am. J. Obstet. Gynecol. 2017, 216, 290.e1–290.e9. [Google Scholar] [CrossRef] [PubMed]
  96. Liao, J.X.; Chen, Y.W.; Shih, M.K.; Tain, Y.L.; Yeh, Y.T.; Chiu, M.H.; Chang, S.K.C.; Hou, C.Y. Resveratrol Butyrate Esters Inhibit BPA-Induced Liver Damage in Male Offspring Rats by Modulating Antioxidant Capacity and Gut Microbiota. Int. J. Mol. Sci. 2021, 22, 5273. [Google Scholar] [CrossRef]
  97. Wei, Z.; Song, L.; Wei, J.; Chen, T.; Chen, J.; Lin, Y.; Xia, W.; Xu, B.; Li, X.; Chen, X.; et al. Maternal exposure to di-(2-ethylhexyl) phthalate alters kidney development through the renin-angiotensin system in offspring. Toxicol. Lett. 2012, 212, 212–221. [Google Scholar] [CrossRef]
  98. Rajagopal, G.; Bhaskaran, R.S.; Karundevi, B. Maternal di-(2-ethylhexyl) phthalate exposure alters hepatic insulin signal transduction and glucoregulatory events in rat F1 male offspring. J. Appl. Toxicol. 2019, 39, 751–763. [Google Scholar] [CrossRef]
  99. Zhu, Y.P.; Chen, L.; Wang, X.J.; Jiang, Q.H.; Bei, X.Y.; Sun, W.L.; Xia, S.J.; Jiang, J.T. Maternal exposure to di-n-butyl phthalate (DBP) induces renal fibrosis in adult rat offspring. Oncotarget 2017, 8, 31101–31111. [Google Scholar] [CrossRef]
  100. Tain, Y.L.; Hou, C.Y.; Chang-Chien, G.P.; Lin, S.; Hsu, C.N. Resveratrol Butyrate Ester Supplementation Blunts the Development of Offspring Hypertension in a Maternal Di-2-ethylhexyl Phthalate Exposure Rat Model. Nutrients 2023, 15, 697. [Google Scholar] [CrossRef]
  101. Sengupta, P. The Laboratory Rat: Relating Its Age with Human’s. Int. J. Prev. Med. 2013, 4, 624–630. [Google Scholar]
  102. Bandookwala, M.; Sengupta, P. 3-Nitrotyrosine: A versatile oxidative stress biomarker for major neurodegenerative diseases. Int. J. Neurosci. 2020, 130, 1047–1062. [Google Scholar] [CrossRef]
  103. DeFreitas, M.J.; Katsoufis, C.P.; Benny, M.; Young, K.; Kulandavelu, S.; Ahn, H.; Sfakianaki, A.; Abitbol, C.L. Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney. Front. Pediatr. 2022, 10, 853722. [Google Scholar] [CrossRef]
  104. Sebastiani, G.; Navarro-Tapia, E.; Almeida-Toledano, L.; Serra-Delgado, M.; Paltrinieri, A.L.; García-Algar, Ó.; Andreu-Fernández, V. Effects of Antioxidant Intake on Fetal Development and Maternal/Neonatal Health during Pregnancy. Antioxidants 2022, 11, 648. [Google Scholar] [CrossRef] [PubMed]
  105. Pisoschi, A.M.; Pop, A. The role of antioxidants in the chemistry of oxidative stress: A review. Eur. J. Med. Chem. 2015, 97, 55–74. [Google Scholar] [CrossRef] [PubMed]
  106. Nimse, S.B.; Palb, D. Free radicals, natural antioxidants, and their reaction mechanisms. RSC Adv. 2015, 5, 27986–28006. [Google Scholar] [CrossRef]
  107. Tamura, H.; Nakamura, Y.; Terron, M.P.; Flores, L.J.; Manchester, L.C.; Tan, D.X.; Sugino, N.; Reiter, R.J. Melatonin and pregnancy in the human. Reprod. Toxicol. 2008, 25, 291–303. [Google Scholar] [CrossRef] [PubMed]
  108. Cipolla-Neto, J.; Amaral, F.G.D. Melatonin as a Hormone: New Physiological and Clinical Insights. Endocr. Rev. 2018, 39, 990–1028. [Google Scholar] [CrossRef] [PubMed]
  109. Lerner, A.B.; Case, J.D.; Takahashi, Y.; Lee, T.H.; Mori, W. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J. Am. Chem. Soc. 1958, 80, 2587. [Google Scholar] [CrossRef]
  110. Back, K.; Tan, D.X.; Reiter, R.J. Melatonin biosynthesis in plants: Multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts. J. Pineal Res. 2016, 61, 426–437. [Google Scholar] [CrossRef]
  111. Hardeland, R.; Tan, D.X.; Reiter, R.J. Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines. J. Pineal Res. 2009, 47, 109–126. [Google Scholar] [CrossRef]
  112. Slominski, R.M.; Reiter, R.J.; Schlabritz-Loutsevitch, N.; Ostrom, R.S.; Slominski, A.T. Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol. Cell Endocrinol. 2012, 351, 152–166. [Google Scholar] [CrossRef]
  113. Ekmekcioglu, C. Melatonin receptors in humans: Biological role and clinical relevance. Biomed. Pharmacother. 2006, 60, 97–108. [Google Scholar] [CrossRef] [PubMed]
  114. Ma, H.; Kang, J.; Fan, W.; He, H.; Huang, F. ROR: Nuclear Receptor for Melatonin or Not? Molecules 2021, 26, 2693. [Google Scholar] [CrossRef] [PubMed]
  115. Tordjman, S.; Chokron, S.; Delorme, R.; Charrier, A.; Bellissant, E.; Jaafari, N.; Fougerou, C. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr. Neuropharmacol. 2017, 15, 434–443. [Google Scholar] [CrossRef]
  116. Carlomagno, G.; Minini, M.; Tilotta, M.; Unfer, V. From Implantation to Birth: Insight into Molecular Melatonin Functions. Int. J. Mol. Sci. 2018, 19, 2802. [Google Scholar] [CrossRef]
  117. Reiter, R.J.; Tan, D.X.; Korkmaz, A.; Rosales-Corral, S.A. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Hum. Reprod. Update 2014, 20, 293–307. [Google Scholar] [CrossRef] [PubMed]
  118. Lanoix, D.; Guérin, P.; Vaillancourt, C. Placental melatonin production and melatonin receptor expression are altered in preeclampsia: New insights into the role of this hormone in pregnancy. J. Pineal Res. 2012, 53, 417–425. [Google Scholar] [CrossRef]
  119. Landgraf, D.; Achten, C.; Dallmann, F.; Oster, H. Embryonic development and maternal regulation of murine circadian clock function. Chronobiol. Int. 2015, 32, 416–427. [Google Scholar] [CrossRef]
  120. Mendez, N.; Abarzua-Catalan, L.; Vilches, N.; Galdames, H.A.; Spichiger, C.; Richter, H.G.; Valenzuela, G.J.; Seron-Ferre, M.; Torres-Farfan, C. Timed maternal melatonin treatment reverses circadian disruption of the fetal adrenal clock imposed by exposure to constant light. PLoS ONE 2012, 7, e42713. [Google Scholar] [CrossRef]
  121. Karamitri, A.; Jockers, R. Melatonin in type 2 diabetes mellitus and obesity. Nat. Rev. Endocrinol. 2019, 15, 105–125. [Google Scholar] [CrossRef]
  122. Akbari, M.; Ostadmohammadi, V.; Tabrizi, R.; Lankarani, K.B.; Heydari, S.T.; Amirani, E.; Reiter, R.J.; Asemi, Z. The effects of melatonin supplementation on inflammatory markers among patients with metabolic syndrome or related disorders: A systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology 2018, 26, 899–907. [Google Scholar] [CrossRef] [PubMed]
  123. Theofilis, P.; Vordoni, A.; Kalaitzidis, R.G. The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal? Am. J. Nephrol. 2022, 53, 565–574. [Google Scholar] [CrossRef] [PubMed]
  124. Ahsanova, E.; Popov, V.; Bulanova, N.; Morozova, T. Hypotensive Action of Melatonin in Patients with Arterial Hypertension. Eur. Cardiol. 2020, 15, e43. [Google Scholar] [CrossRef] [PubMed]
  125. Ozkalayci, F.; Kocabas, U.; Altun, B.U.; Pandi-Perumal, S.; Altun, A. Relationship Between Melatonin and Cardiovascular Disease. Cureus 2021, 13, e12935. [Google Scholar] [CrossRef] [PubMed]
  126. Verteramo, R.; Pierdomenico, M.; Greco, P.; Milano, C. The Role of Melatonin in Pregnancy and the Health Benefits for the Newborn. Biomedicines 2022, 10, 3252. [Google Scholar] [CrossRef] [PubMed]
  127. Aversa, S.; Pellegrino, S.; Barberi, I.; Reiter, R.J.; Gitto, E. Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period. J. Matern. Fetal Neonatal Med. 2012, 25, 207–221. [Google Scholar] [CrossRef] [PubMed]
  128. Vine, T.; Brown, G.M.; Frey, B.N. Melatonin use during pregnancy and lactation: A scoping review of human studies. Braz. J. Psychiatry 2022, 44, 342–348. [Google Scholar] [CrossRef] [PubMed]
  129. Lee, S.K.; Sirajudeen, K.N.; Sundaram, A.; Zakaria, R.; Singh, H.J. Effects of antenatal, postpartum and post-weaning melatonin supplementation on blood pressure and renal antioxidant enzyme activities in spontaneously hypertensive rats. J. Physiol. Biochem. 2011, 67, 249–257. [Google Scholar] [CrossRef]
  130. Tain, Y.L.; Huang, L.T.; Hsu, C.N.; Lee, C.T. Melatonin therapy prevents programmed hypertension and nitric oxide deficiency in offspring exposed to maternal caloric restriction. Oxid. Med. Cell. Longev. 2014, 2014, 283180. [Google Scholar] [CrossRef]
  131. Tain, Y.L.; Lee, C.T.; Chan, J.Y.; Hsu, C.N. Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal N(G)-Nitro-L-arginine-methyl ester (L-NAME)-induced fetal programming of hypertension in adult male offspring. Am. J. Obstet. Gynecol. 2016, 215, 636. [Google Scholar] [CrossRef] [PubMed]
  132. Tain, Y.L.; Chan, J.Y.H.; Lee, C.T.; Hsu, C.N. Maternal Melatonin Therapy Attenuates Methyl-Donor Diet-Induced Programmed Hypertension in Male Adult Rat Offspring. Nutrients 2018, 10, E1407. [Google Scholar] [CrossRef] [PubMed]
  133. Tain, Y.L.; Leu, S.; Wu, K.L.; Lee, W.C.; Chan, J.Y. Melatonin prevents maternal fructose intake-induced programmed hypertension in the offspring: Roles of nitric oxide and arachidonic acid metabolites. J. Pineal Res. 2014, 57, 80–89. [Google Scholar] [CrossRef] [PubMed]
  134. Lapa Neto, C.J.C.; de Melo, I.M.F.; Alpiovezza, P.K.B.M.; de Albuquerque, Y.M.L.; Francisco Soares, A.; Teixeira, Á.A.C.; Wanderley-Teixeira, V. Melatonin associated with a high-fat diet during pregnancy and lactation prevents liver changes in the offspring. Gen. Comp. Endocrinol. 2023, 343, 114357. [Google Scholar] [CrossRef] [PubMed]
  135. Tain, Y.L.; Chen, C.C.; Sheen, J.M.; Yu, H.R.; Tiao, M.M.; Kuo, H.C.; Huang, L.T. Melatonin attenuates prenatal dexamethasone-induced blood pressure increase in a rat model. J. Am. Soc. Hypertens. 2014, 8, 216–226. [Google Scholar] [CrossRef]
  136. Wu, T.H.; Kuo, H.C.; Lin, I.C.; Chien, S.J.; Huang, L.T.; Tain, Y.L. Melatonin prevents neonatal dexamethasone induced programmed hypertension: Histone deacetylase inhibition. J. Steroid Biochem. Mol. Biol. 2014, 144, 253–259. [Google Scholar] [CrossRef]
  137. Baxi, D.B.; Singh, P.K.; Vachhrajani, K.D.; Ramachandran, A.V. Neonatal corticosterone programs for thrifty phenotype adult diabetic manifestations and oxidative stress: Countering effect of melatonin as a deprogrammer. J. Matern. Fetal Neonatal Med. 2012, 25, 1574–1585. [Google Scholar] [CrossRef]
  138. Kim, C.Y.; Lee, B.N.; Kim, J.S. Effects of maternal-melatonin treatment on open-field behaviors and hypertensive phenotype in spontaneously hypertensive rats’ (SHR) offspring. Exp. Anim. 2002, 51, 69–74. [Google Scholar] [CrossRef]
  139. Hansell, J.A.; Richter, H.G.; Camm, E.J.; Herrera, E.A.; Blanco, C.E.; Villamor, E.; Patey, O.V.; Lock, M.C.; Trafford, A.W.; Galli, G.L.J.; et al. Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy. J. Pineal Res. 2022, 72, e12766. [Google Scholar] [CrossRef]
  140. Kett, M.M.; Denton, K. Renal programming: Cause for concern? Am. J. Physiol. Integr. Comp. Physiol. 2011, 300, R791–R803. [Google Scholar] [CrossRef] [PubMed]
  141. Chevalier, R.L. Evolution, kidney development, and chronic kidney disease. Semin. Cell Dev. Biol. 2019, 91, 119–131. [Google Scholar] [CrossRef]
  142. Simko, F.; Reiter, R.J.; Pechanova, O.; Paulis, L. Experimental models of melatonin-deficient hypertension. Front. Biosci. 2013, 18, 616–625. [Google Scholar] [CrossRef]
  143. Hrenak, J.; Paulis, L.; Repova, K.; Aziriova, S.; Nagtegaal, E.J.; Reiter, R.J.; Simko, F. Melatonin and renal protection: Novel perspectives from animal experiments and human studies (review). Curr. Pharm. Des. 2015, 21, 936–949. [Google Scholar] [CrossRef]
  144. Tain, Y.L.; Huang, L.T.; Chan, J.Y. Transcriptional regulation of programmed hypertension by melatonin: An epigenetic perspective. Int. J. Mol. Sci. 2014, 15, 18484–18495. [Google Scholar] [CrossRef] [PubMed]
  145. Korkmaz, A.; Reiter, R.J. Epigenetic regulation: A new research area for melatonin? J. Pineal Res. 2008, 44, 41–44. [Google Scholar] [CrossRef]
  146. Goszcz, K.; Deakin, S.J.; Duthie, G.G.; Stewart, D.; Leslie, S.J.; Megson, I.L. Antioxidants in Cardiovascular Therapy: Panacea or False Hope? Front. Cardiovasc. Med. 2015, 2, 29. [Google Scholar] [CrossRef] [PubMed]
  147. Petrosillo, G.; Moro, N.; Ruggiero, F.M.; Paradies, G. Melatonin Inhibits Cardiolipin Peroxidation in Mitochondria and Prevents the Mitochondrial Permeability Transition and Cytochrome c Release. Free Radic. Biol. Med. 2009, 47, 969–974. [Google Scholar] [CrossRef]
  148. Liu, Y.; Li, L.N.; Guo, S.; Zhao, X.Y.; Liu, Y.Z.; Liang, C.; Tu, S.; Wang, D.; Li, L.; Dong, J.Z.; et al. Melatonin Improves Cardiac Function in a Mouse Model of Heart Failure with Preserved Ejection Fraction. Redox Biol. 2018, 18, 211–221. [Google Scholar] [CrossRef] [PubMed]
  149. Veneroso, C.; Tuñón, M.J.; González-Gallego, J.; Collado, P.S. Melatonin Reduces Cardiac Inflammatory Injury Induced by Acute Exercise. J. Pineal Res. 2009, 47, 184–191. [Google Scholar] [CrossRef]
  150. Gao, L.; Zhao, Y.C.; Liang, Y.; Lin, X.H.; Tan, Y.J.; Wu, D.D.; Li, X.Z.; Ye, B.Z.; Kong, F.Q.; Sheng, J.Z.; et al. The impaired myocardial ischemic tolerance in adult offspring of diabetic pregnancy is restored by maternal melatonin treatment. J. Pineal Res. 2016, 61, 340–352. [Google Scholar] [CrossRef]
  151. Fantuzzi, G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005, 115, 911–919. [Google Scholar] [CrossRef]
  152. Gonzaga, N.A.; Awata, W.M.C.; Ficher, S.P.; Assis, V.O.; Alves, J.V.; Tostes, R.C.; Tirapelli, C.R. Melatonin reverses the loss of the anticontractile effect of perivascular adipose tissue in obese rats. J. Pineal Res. 2021, 70, e12710. [Google Scholar] [CrossRef]
  153. Shah, S.A.; Khan, M.; Jo, M.H.; Jo, M.G.; Amin, F.U.; Kim, M.O. Melatonin stimulates the SIRT1/Nrf2 signaling pathway counteracting lipopolysaccharide (LPS)-induced oxidative stress to rescue postnatal rat brain. CNS Neurosci. Ther. 2017, 23, 33–44. [Google Scholar] [CrossRef]
  154. Moniruzzaman, M.; Ghosal, I.; Das, D.; Chakraborty, S.B. Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk/Akt/NFkB pathway. Biol. Res. 2018, 51, 17. [Google Scholar] [CrossRef]
  155. Hermoso, D.; Shimada, L.; Gilglioni, E.; Constantin, J.; Mito, M.; Hermoso, A.; Salgueiro-Pagadigorria, C.; Iwamoto, E. Melatonin protects female rats against steatosis and liver oxidative stress induced by oestrogen deficiency. Life Sci. 2016, 157, 178–186. [Google Scholar] [CrossRef] [PubMed]
  156. Clarke, T.C.; Black, L.I.; Stussman, B.J.; Barnes, P.M.; Nahin, R.L. Trends in the use of complementary health approaches among adults: United States, 2002–2012. Natl. Health Stat. Rep. 2015, 79, 1–16. [Google Scholar]
  157. Sugden, D. Psychopharmacological effects of melatonin in mouse and rat. J. Pharmacol. Exp. Ther. 1983, 227, 587–591. [Google Scholar] [PubMed]
  158. Reagan-Shaw, S.; Nihal, M.; Ahmad, N. Dose translation from animal to human studies revisited. FASEB J. 2008, 22, 659–661. [Google Scholar] [CrossRef] [PubMed]
  159. Cardinali, D. Are melatonin doses employed clinically adequate for melatonin-induced cytoprotection? Melatonin Res. 2019, 2, 106–132. [Google Scholar] [CrossRef]
  160. Hobson, S.R.; Gurusinghe, S.; Lim, R.; Alers, N.O.; Miller, S.L.; Kingdom, J.C.; Wallace, E.M. Melatonin improves endothelial function in vitro and prolongs pregnancy in women with early-onset preeclampsia. J. Pineal Res. 2018, 65, e12508. [Google Scholar] [CrossRef] [PubMed]
  161. Boutin, J.A.; Kennaway, D.J.; Jockers, R. Melatonin: Facts, Extrapolations and Clinical Trials. Biomolecules 2023, 13, 943. [Google Scholar] [CrossRef]
  162. Abiramalatha, T.; Ramaswamy, V.V.; Ponnala, A.K.; Kallem, V.R.; Murkunde, Y.V.; Punnoose, A.M.; Vivekanandhan, A.; Pullattayil, A.K.; Amboiram, P. Emerging neuroprotective interventions in periventricular leukomalacia—A systematic review of preclinical studies. Expert Opin. Investig. Drugs 2022, 31, 305–330. [Google Scholar] [CrossRef] [PubMed]
  163. Aly, H.; Elmahdy, H.; El-Dib, M.; Rowisha, M.; Awny, M.; El-Gohary, T.; Elbatch, M.; Hamisa, M.; El-Mashad, A.R. Melatonin use for neuroprotection in perinatal asphyxia: A randomized controlled pilot study. J. Perinatol. 2015, 35, 186–191. [Google Scholar] [CrossRef] [PubMed]
  164. Gitto, E.; Reiter, R.J.; Amodio, A.; Romeo, C.; Cuzzocrea, E.; Sabatino, G.; Buonocore, G.; Cordaro, V.; Trimarchi, G.; Barberi, I. Early indicators of chronic lung disease in preterm infants with respiratory distress syndrome and their inhibition by melatonin. J. Pineal Res. 2004, 36, 250–255. [Google Scholar] [CrossRef] [PubMed]
  165. Gitto, E.; Karbownik, M.; Reiter, R.J.; Tan, D.X.; Cuzzocrea, S.; Chiurazzi, P.; Cordaro, S.; Corona, G.; Trimarchi, G.; Barberi, I. Effects of melatonin treatment in septic newborns. Pediatr. Res. 2001, 50, 756–760. [Google Scholar] [CrossRef] [PubMed]
  166. Villanueva, C.; Kross, R.D. Antioxidant-induced stress. Int. J. Mol. Sci. 2012, 13, 2091–2109. [Google Scholar] [CrossRef]
  167. Wölfler, A.; Caluba, H.C.; Abuja, P.M.; Dohr, G.; Schauenstein, K.; Liebmann, P.M. Prooxidant activity of melatonin promotes fas-induced cell death in human leukemic Jurkat cells. FEBS Lett. 2001, 502, 127–131. [Google Scholar] [CrossRef]
  168. Halliwell, B. The antioxidant paradox. Lancet 2000, 355, 1179–1180. [Google Scholar] [CrossRef]
Antioxidants 13 00226 g001
Figure 1. Schematic representation of the interrelationships between early-life oxidative stress, fetal programming, and cardiovascular–kidney–metabolic syndrome in later life.
Figure 1. Schematic representation of the interrelationships between early-life oxidative stress, fetal programming, and cardiovascular–kidney–metabolic syndrome in later life.
Antioxidants 13 00226 g001
Antioxidants 13 00226 g002
Figure 2. Overview of perinatal use of melatonin as a reprogramming strategy to prevent developmental programming of cardiovascular–kidney–metabolic syndrome.
Figure 2. Overview of perinatal use of melatonin as a reprogramming strategy to prevent developmental programming of cardiovascular–kidney–metabolic syndrome.
Antioxidants 13 00226 g002
Antioxidants 13 00226 g003
Figure 3. Role of melatonin in pregnancy.
Figure 3. Role of melatonin in pregnancy.
Antioxidants 13 00226 g003
Table 1. Animal models displaying CKM syndrome in adult offspring related to oxidative stress.
Table 1. Animal models displaying CKM syndrome in adult offspring related to oxidative stress.
Model TimingAge at Evaluation (Weeks)Features of CKM SyndromeOxidative StressReferences
Caloric restriction, 50%Throughout gestation and lactation12–16Hypertension, insulin resistance, and kidney disease↑Renal 8-OHdG expression, ↑3-NT, ↑ADMA, ↓NO[53,54,55]
Protein restriction, 6–9%Gestation12Hypertension, insulin resistance, and kidney disease↑F2-isoprostane, ↑3-NT, ↓SOD and GPX activity, ↓glutathione[56,57,58]
Maternal high-fructose diet, 60%Throughout gestation and lactation12–52Hypertension, obesity, insulin resistance, and dyslipidemia ↑Renal 8-OHdG expression ↑MDA, ↑Brain NADPH-oxidase expression; ↑ROS, ↓NO[59,60,61,62,63]
Maternal high-fat diet, 58%Throughout gestation and lactation16Hypertension, obesity, insulin resistance, dyslipidemia, and kidney disease↓SOD activity, ↑Renal MDA; ↑Renal 8-OHdG expression[64,65,66,67,68]
Maternal diabetesNeonatal streptozotocin injection12–16Hypertension, obesity, insulin resistance, dyslipidemia, and kidney disease↑Renal 3-NT and TBARS; ↑ROS, ↓SOD activity, ↓NO; ↑ADMA[69,70,71]
Uteroplacental insufficiencyBilateral uterine artery ligation on gestation22–30Hypertension, dyslipidemia insulin resistance, and kidney disease↑Renal NADPH-oxidase dependent superoxide, ↑Urinary F2-isoprostane level [72,73,74,75]
Maternal chronodisruption Gestation12–52Hypertension and insulin resistance↑Brain ROS[76,77,78]
Maternal stressPerinatal dexamethasone administration16–24Hypertension, obesity, insulin resistance, and kidney disease↓Gpx1 expression, ↑NADPH-oxidase, ↓Renal NO, ↑ADMA, ↑Renal 8-OHdG expression[79,80,81,82]
Maternal chronic kidney diseaseThroughout gestation and lactation12Hypertension and kidney disease↑Renal 8-OHdG expression, ↓NO[83,84]
Nicotine exposurePerinatal nicotine exposure20–32Hypertension, hyperlipidemia, steatosis, and kidney disease↑MDA, ↑3-NT, ↑NADPH oxidase, ↑4-NHE, ↓GPx1 activity[85,86,87,88]
Ethanol exposure Gestation24Hypertension and insulin resistance↓SOD1, ↓CAT, ↓GPX, ↑NOX2[89,90,91]
TCDD exposureGestation and lactation12Hypertension, cardiac hypertrophy, and kidney disease↑Renal 8-OHdG expression[92,93]
BPA exposureGestation and lactation16–24Hypertension, insulin resistance, and steatosis↓SOD, ↓CAT, ↑Renal 8-OHdG expression, ↑ADMA, ↓NO[94,95,96]
DEHP exposureGestation and lactation12–21Hypertension and insulin resistance↑Renal ROS, ↑Renal 8-OHdG expression[97,98,99,100]
TCDD = 2,3,7,8-tetrachlorodibenzo-p-dioxin; BPA = bisphenol A; DEHP = di-n-butyl phthalate; ADMA = asymmetric dimethylarginine; 8-OHdG = 8-hydroxy-2’-deoxyguanosine; NO = nitric oxide; ROS = reactive oxygen species; 3-NT = 3-nitrotyrosine; TBARS = thiobarbituric acid; MDA = malondialdehyde; 4-NHE = 4-hydroxynonenal; CAT = catalase; GPX = glutathione peroxidase; SOD = superoxidase dismutase; NOX2 = NADPH oxidase 2.
Table 2. Protective effects of perinatal melatonin supplementation against CKM syndrome in rat models.
Table 2. Protective effects of perinatal melatonin supplementation against CKM syndrome in rat models.
Treatment Period and DoseModelAge at Evaluation (Weeks)Prevented CKM Syndrome in OffspringRef.
0.5 mg/kg/day p.o. throughout gestation and lactationMaternal chronodisruption18Insulin resistance[77]
10 mg/kg/day p.o. throughout gestation and lactationMaternal chronodisruption12Hypertension[78]
10 mg/kg/day p.o. during pregnancyMaternal hypertension8Hypertension[129]
10 mg/kg/day p.o. throughout gestation and lactationCaloric restriction 12Hypertension and kidney disease[130]
10 mg/kg/day p.o. throughout gestation and lactationMaternal L-NAME exposure12Hypertension and kidney disease[131]
10 mg/kg/day p.o. throughout gestation and lactationMaternal high methyl-donor diet12Hypertension[132]
10 mg/kg/day p.o. throughout gestation and lactationMaternal high-fructose diet12Hypertension[133]
5 mg/kg/day i.p. throughout gestation and lactationMaternal high-fat diet3Obesity, hyperglycemia, hyperlipidemia, and liver steatosis[134]
10 mg/kg/day p.o. throughout gestation and lactationPrenatal dexamethasone exposure16Hypertension, liver steatosis, and kidney disease[81,135]
10 mg/kg/day p.o. throughout gestation and lactationNeonatal dexamethasone exposure16Hypertension[136]
1 mg/kg/day at night
from postnatal day 2 to 14		Neonatal corticosterone exposure16Diabetes, hyperlipidemia, liver steatosis, and kidney disease[137]
0.2 mg/kg/day p.o. throughout gestation and lactationMaternal hypertension27Hypertension[138]
0.05 mg/kg/day p.o.during gestation Maternal hypoxia16Cardiovascular disease[139]
p.o. = per oral; i.p. = intraperitoneal; L-NAME = NG-nitro-l-arginine methyl ester.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Tain, Y.-L.; Hsu, C.-N. Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models. Antioxidants 2024, 13, 226. https://doi.org/10.3390/antiox13020226

AMA Style

Tain Y-L, Hsu C-N. Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models. Antioxidants. 2024; 13(2):226. https://doi.org/10.3390/antiox13020226

Chicago/Turabian Style

Tain, You-Lin, and Chien-Ning Hsu. 2024. "Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models" Antioxidants 13, no. 2: 226. https://doi.org/10.3390/antiox13020226

APA Style

Tain, Y.-L., & Hsu, C.-N. (2024). Melatonin Use during Pregnancy and Lactation Complicated by Oxidative Stress: Focus on Offspring’s Cardiovascular–Kidney–Metabolic Health in Animal Models. Antioxidants, 13(2), 226. https://doi.org/10.3390/antiox13020226

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop