Elucidating the Molecular Pathways and Therapeutic Interventions of Gaseous Mediators in the Context of Fibrosis

Li, Aohan; Wu, Siyuan; Li, Qian; Wang, Qianqian; Chen, Yingqing

doi:10.3390/antiox13050515

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Elucidating the Molecular Pathways and Therapeutic Interventions of Gaseous Mediators in the Context of Fibrosis

by

Aohan Li

^1,†,

Siyuan Wu

^1,†,

Qian Li

^1,†,

Qianqian Wang

^1,2,*

and

Yingqing Chen

^1,2,*

¹

Chronic Disease Research Center, Medical College, Dalian University, Dalian 116622, China

²

Engineering Technology Research Center for The Utilization of Functional Components of Organic Natural Products, Dalian University, Dalian 116622, China

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Antioxidants 2024, 13(5), 515; https://doi.org/10.3390/antiox13050515

Submission received: 23 February 2024 / Revised: 13 April 2024 / Accepted: 22 April 2024 / Published: 25 April 2024

(This article belongs to the Special Issue Oxidative Stress and Redox Regulation in Chronic Inflammatory Disorders)

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Abstract

Fibrosis, a pathological alteration of the repair response, involves continuous organ damage, scar formation, and eventual functional failure in various chronic inflammatory disorders. Unfortunately, clinical practice offers limited treatment strategies, leading to high mortality rates in chronic diseases. As part of investigations into gaseous mediators, or gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H₂S), numerous studies have confirmed their beneficial roles in attenuating fibrosis. Their therapeutic mechanisms, which involve inhibiting oxidative stress, inflammation, apoptosis, and proliferation, have been increasingly elucidated. Additionally, novel gasotransmitters like hydrogen (H₂) and sulfur dioxide (SO₂) have emerged as promising options for fibrosis treatment. In this review, we primarily demonstrate and summarize the protective and therapeutic effects of gaseous mediators in the process of fibrosis, with a focus on elucidating the underlying molecular mechanisms involved in combating fibrosis.

Keywords: gaseous mediators; fibrosis; oxidative stress; inflammation; myofibroblasts

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MDPI and ACS Style

Li, A.; Wu, S.; Li, Q.; Wang, Q.; Chen, Y. Elucidating the Molecular Pathways and Therapeutic Interventions of Gaseous Mediators in the Context of Fibrosis. Antioxidants 2024, 13, 515. https://doi.org/10.3390/antiox13050515

AMA Style

Li A, Wu S, Li Q, Wang Q, Chen Y. Elucidating the Molecular Pathways and Therapeutic Interventions of Gaseous Mediators in the Context of Fibrosis. Antioxidants. 2024; 13(5):515. https://doi.org/10.3390/antiox13050515

Chicago/Turabian Style

Li, Aohan, Siyuan Wu, Qian Li, Qianqian Wang, and Yingqing Chen. 2024. "Elucidating the Molecular Pathways and Therapeutic Interventions of Gaseous Mediators in the Context of Fibrosis" Antioxidants 13, no. 5: 515. https://doi.org/10.3390/antiox13050515

APA Style

Li, A., Wu, S., Li, Q., Wang, Q., & Chen, Y. (2024). Elucidating the Molecular Pathways and Therapeutic Interventions of Gaseous Mediators in the Context of Fibrosis. Antioxidants, 13(5), 515. https://doi.org/10.3390/antiox13050515

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Elucidating the Molecular Pathways and Therapeutic Interventions of Gaseous Mediators in the Context of Fibrosis

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