Glutathione: Antioxidant Properties Dedicated to Nanotechnologies
Abstract
:1. Introduction: Biochemical Implication of Glutathione in Redox Homeostasis
2. Glutathione and Antioxidant/Pro-Oxidant Properties
3. Glutathione and Redox Signaling
4. Methodologies for Dosage of Glutathione/Glutathiolated Proteins
5. Repletion of Glutathione: Therapeutic Opportunities and Challenges
6. GSH Decoration as a Tool for Targeted Drug Delivery Systems
6.1. Brain-Targeted Drug Delivery
6.2. Intracellular-Targeted Drug Delivery
7. Conclusions
Acknowledgments
Conflicts of Interest
Abbreviations
ABTS | 2,2′-Azino-bis(3-éthylbenzothiazoline-6-sulphonic) acid |
AuNP | Gold nanoparticle |
BSA | Bovine serum albumin |
BSO | l-Buthionine-[S,R]-sulfoximine |
CFTR | Cystic fibrosis transmembrane conductance regulator |
DIC | Dicarboxylate carrier |
FRAP | Ferric reducing antioxidant power |
GCL | γ-Glutamylcysteinyl ligase |
GGT | γ-Glutamyltransferase |
GPx | Glutathione peroxidase |
GR | Glutathione disulfide reductase |
GS | Glutathione synthase |
GSH | Reduced glutathione |
GSH-Oet | Glutathione monoester |
GSNO | S-Nitrosoglutathione |
GSOH | Glutathione sulfenic acid |
GSSG | Disulfide glutathione |
GSTs | Glutathione-S-transferases |
LDL | Low-density lipoprotein |
MRP | Multidrug resistance-associated protein |
NAC | N-Acetylcysteine |
NFE2L2 | Nuclear factor erythroid-derived 2-like 2 |
NP | Nanoparticle |
OGC | Oxoglutarate carrier |
OPA | O-Phthalaldehyde |
OTC | l-2-Oxothiazolidine-4-carboxylate |
PEG | Poly(ethylene)glycol |
PLGA | Poly(lactic-co-glycolic acid) |
PSHs | Protein thiol groups |
PSSGs | S-Glutathiolated proteins |
PTCA | 2-(RS)-n-Propylthiazolidine-4(R)-carboxylic-acid |
RyR1 | Ryanodine receptor type 1 |
SAMe | S-Adenosylmethionine |
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Gaucher, C.; Boudier, A.; Bonetti, J.; Clarot, I.; Leroy, P.; Parent, M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants 2018, 7, 62. https://doi.org/10.3390/antiox7050062
Gaucher C, Boudier A, Bonetti J, Clarot I, Leroy P, Parent M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants. 2018; 7(5):62. https://doi.org/10.3390/antiox7050062
Chicago/Turabian StyleGaucher, Caroline, Ariane Boudier, Justine Bonetti, Igor Clarot, Pierre Leroy, and Marianne Parent. 2018. "Glutathione: Antioxidant Properties Dedicated to Nanotechnologies" Antioxidants 7, no. 5: 62. https://doi.org/10.3390/antiox7050062