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Antioxidants
Volume 7
Issue 9
10.3390/antiox7090122
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Review

The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases

by
Beichen Jiang
and
Jackob Moskovitz
*
Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
*
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(9), 122; https://doi.org/10.3390/antiox7090122
Submission received: 25 July 2018 / Revised: 15 August 2018 / Accepted: 16 September 2018 / Published: 18 September 2018
(This article belongs to the Special Issue Methionine Sulfoxide Reductases and Oxidative Damage)
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Abstract

This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated.
Keywords: methionine sulfoxide reductase; methionine oxidation; oxidative stress methionine sulfoxide reductase; methionine oxidation; oxidative stress

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MDPI and ACS Style

Jiang, B.; Moskovitz, J. The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases. Antioxidants 2018, 7, 122. https://doi.org/10.3390/antiox7090122

AMA Style

Jiang B, Moskovitz J. The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases. Antioxidants. 2018; 7(9):122. https://doi.org/10.3390/antiox7090122

Chicago/Turabian Style

Jiang, Beichen, and Jackob Moskovitz. 2018. "The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases" Antioxidants 7, no. 9: 122. https://doi.org/10.3390/antiox7090122

APA Style

Jiang, B., & Moskovitz, J. (2018). The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases. Antioxidants, 7(9), 122. https://doi.org/10.3390/antiox7090122

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