Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design
Abstract
:1. Introduction
Oxidative Stress in Schizophrenia and Depression
2. Antipsychotic Drugs
2.1. First Generation (Typical) Antipsychotics
2.2. Second Generation (Atypical) Antipsychotics
2.3. Aripiprazole
2.4. Other Agents against Oxidative Stress: Natural and Dietary Compounds
3. Antidepressant Drugs
3.1. Conventional Antidepressants
3.2. Natural Compounds
4. In Silico Approaches
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
List of Acronyms
Central nervous system | CNS |
Reactive oxygen species | ROS |
Reactive nitrogen species | RNS |
Deoxyribonucleic acid DNA | DNA |
Polyunsaturated fatty acids | PUFAs |
Superoxide dismutase | SOD |
Glutathione peroxidase | GPx |
Catalase | CAT |
Glutathione | GSH |
Thiobarbituric acid related substances | TBARS |
Monoamine oxidase A | MAO-A |
Monoamine oxidase B | MAO-B |
Dopamine | DA |
Catechol-O-methyl transferase | COMT |
6-hydroxydopamine | 6-OHDA |
8-hydroxy-2′-deoxyguanosine | 8-OHdG |
Dihydrorhodamine 123 | DHR123 |
2,2′-azinobis(3-ethylbenzthiazoline-6-sulfonate) | ABTS |
2,2-diphenyl-1-picryl-hydrazyl-hydrate | DPPH |
Ferric reducing antioxidant power | FRAP |
Ultra-performance liquid chromatography-tandem mass spectrometry | UPLC-MS/MS |
N-methyl-4-phenylpyridinium | MPP+ |
Nicotinamide adenine dinucleotide phosphate | NADPH |
Glutamate-cysteine ligase modifier subunit knockout | GCLM-KO |
Γ-aminobutyric acid | GABA |
Extracellular-signal-regulated kinase | ERK |
Protein kinase B | AKT |
area under the curve | AUC |
Quantitative structure activity relationship | QSAR |
Quantum mechanics | QM |
Density functional theory | DFT |
Hydrogen atom transfer | HAT |
Integral equation formalism polarizable continuum model | IEFPCM |
Sequential electron proton transfer | SEPT |
Sequential proton loss electron transfer | SPLET |
Iodothyronine deiodinase | DIO |
Thioredoxin reductases | TrxR |
Methionine sulfoxide reductases | Msr |
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Ribaudo, G.; Bortoli, M.; Pavan, C.; Zagotto, G.; Orian, L. Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design. Antioxidants 2020, 9, 714. https://doi.org/10.3390/antiox9080714
Ribaudo G, Bortoli M, Pavan C, Zagotto G, Orian L. Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design. Antioxidants. 2020; 9(8):714. https://doi.org/10.3390/antiox9080714
Chicago/Turabian StyleRibaudo, Giovanni, Marco Bortoli, Chiara Pavan, Giuseppe Zagotto, and Laura Orian. 2020. "Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design" Antioxidants 9, no. 8: 714. https://doi.org/10.3390/antiox9080714
APA StyleRibaudo, G., Bortoli, M., Pavan, C., Zagotto, G., & Orian, L. (2020). Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design. Antioxidants, 9(8), 714. https://doi.org/10.3390/antiox9080714