Quercetin-Loaded Polycaprolactone-Polyvinylpyrrolidone Electrospun Membranes for Health Application: Design, Characterization, Modeling and Cytotoxicity Studies
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Fabrication of Quercetin-Loaded Membranes
2.3. Methods
2.3.1. Morphological Analysis
2.3.2. Contact Angle and Liquid Retention Tests
2.3.3. Release Kinetic of Quercetin
2.3.4. Photostability
2.4. Computational Work
2.5. Biological Activity
2.5.1. Cells Culture
2.5.2. Cell Viability Assay
2.6. Statistical Analysis
3. Results
3.1. Morphological Analysis
3.2. Computational Analysis
3.3. Liquid Retention Tests
3.4. Release Kinetics of Quercetin
3.5. Photostability
3.6. Effects of Quercetin-Loaded Membrane on Cell Viability
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Model | PBS (pH = 7.4) | HCl SLN (pH = 3) | ||
---|---|---|---|---|
Values | Values | |||
Zeroth | K0 | 0.66 | K0 | 0.56 |
R2 | <0 | R2 | <0 | |
Gompertz | ||||
α | 0.83 | α | 0.97 | |
β | −2.7 | β | −1.5 | |
R2 | 0.99 | R2 | 0.98 | |
Higuchi | ||||
KH | 9.49 | KH | 7.93 | |
R2 | <0 | R2 | <0 | |
Korsmeyer–Peppas | ||||
KR | 48.60 | KR | 37.41 | |
n | 0.13 | n | 0.14 | |
R2 | 0.58 | R2 | 0.73 |
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Viscusi, G.; Paolella, G.; Lamberti, E.; Caputo, I.; Gorrasi, G. Quercetin-Loaded Polycaprolactone-Polyvinylpyrrolidone Electrospun Membranes for Health Application: Design, Characterization, Modeling and Cytotoxicity Studies. Membranes 2023, 13, 242. https://doi.org/10.3390/membranes13020242
Viscusi G, Paolella G, Lamberti E, Caputo I, Gorrasi G. Quercetin-Loaded Polycaprolactone-Polyvinylpyrrolidone Electrospun Membranes for Health Application: Design, Characterization, Modeling and Cytotoxicity Studies. Membranes. 2023; 13(2):242. https://doi.org/10.3390/membranes13020242
Chicago/Turabian StyleViscusi, Gianluca, Gaetana Paolella, Elena Lamberti, Ivana Caputo, and Giuliana Gorrasi. 2023. "Quercetin-Loaded Polycaprolactone-Polyvinylpyrrolidone Electrospun Membranes for Health Application: Design, Characterization, Modeling and Cytotoxicity Studies" Membranes 13, no. 2: 242. https://doi.org/10.3390/membranes13020242