Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Synthesis of ACPs and CaPs
2.3. Characterization
3. Results and Discussion
3.1. Synthesis and Characterization of ACPs and CaPs
3.2. Stability of ACPs
3.3. Cytocompatibility Study of ACPs
3.4. Drug Loading and In Vitro Release of AL with ACP053 as Carrier
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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C | H | Ca | P | Ca/P | Estimated Carbonate Content (wt.%) | |
---|---|---|---|---|---|---|
ACP032 | 0.26 | 1.56 | 0.84 | 0.38 | 2.21 | ~16% |
ACP053 | 0.07 | 1.73 | 0.86 | 0.56 | 1.53 | ~4% |
Samples | Brunauer–Emmett–Teller (BET) Surface Area (m2/g) | Peak Pore-Size a (nm) | Pore Volume b (cm3/g) | Density (g/cm3) c | Calculated Particle Size d (nm) |
---|---|---|---|---|---|
ACP032 | 423 | 5.4 | 0.57 | 2.49 | 5.7 |
ACP053 | 418 | 9.3 | 1.05 | 2.59 | 5.6 |
CaP058 | 294 | 18.6 | 1.39 | 2.61 | 7.8 |
CaP068 | 133 | 18.6 | 0.62 | 2.70 | 16.7 |
CaP078 | 52 | 6.8 | 0.11 | - | - |
CaP088 | 6 | 18.6 | 0.10 | - | - |
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Sun, R.; Åhlén, M.; Tai, C.-W.; Bajnóczi, É.G.; de Kleijne, F.; Ferraz, N.; Persson, I.; Strømme, M.; Cheung, O. Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications. Nanomaterials 2020, 10, 20. https://doi.org/10.3390/nano10010020
Sun R, Åhlén M, Tai C-W, Bajnóczi ÉG, de Kleijne F, Ferraz N, Persson I, Strømme M, Cheung O. Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications. Nanomaterials. 2020; 10(1):20. https://doi.org/10.3390/nano10010020
Chicago/Turabian StyleSun, Rui, Michelle Åhlén, Cheuk-Wai Tai, Éva G. Bajnóczi, Fenne de Kleijne, Natalia Ferraz, Ingmar Persson, Maria Strømme, and Ocean Cheung. 2020. "Highly Porous Amorphous Calcium Phosphate for Drug Delivery and Bio-Medical Applications" Nanomaterials 10, no. 1: 20. https://doi.org/10.3390/nano10010020