An Ultrasensitive Non-Enzymatic Sensor for Quantitation of Anti-Cancer Substance Chicoric Acid Based on Bimetallic Nanoalloy with Polyetherimide-Capped Reduced Graphene Oxide
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents and Apparatus
2.2. Preparation of PEI-Functionalized RGO
2.3. Preparation of Au@Pt-PEI-RGO
2.4. Preparation of Modified Electrodes
3. Results and Discussion
3.1. Characterization of Au@Pt-PEI-RGO Nanocomposites
3.2. Electrochemical Behavior of Obtained Materials
3.3. Electrochemical Response of Chicoric Acid at Au@Pt-PEI-RGO/GCE
3.4. Performance of the Proposed Sensor
3.4.1. Optimization of the Experimental Variables
3.4.2. Electrochemical Determination of Chicoric Acid
3.4.3. Interference Immunity, Repeatability, and Stability Studies
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Methods | Detection Range | Limit of Detection | Reference |
---|---|---|---|
High-performance liquid chromatography (HPLC) | 0.25 M–1.25 M | 11 mM | [50] |
Liquid chromatography coupled with tandem mass spectrometry (HPLC–MS/MS) | 0.05 mM–2 mM | 2.23 μM | [51] |
Capillary electrophoresis (CE) | 74.1 mM–592.8 mM | 1.1 mM | [52] |
Electrochemical sensor based on Au@Pt-PEI-RGO nanohybrids | 0.3 μM–0.03 mM | 4.8 nM | This work |
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Jiao, J.; Pan, M.; Liu, X.; Liu, J.; Li, B.; Chen, Q. An Ultrasensitive Non-Enzymatic Sensor for Quantitation of Anti-Cancer Substance Chicoric Acid Based on Bimetallic Nanoalloy with Polyetherimide-Capped Reduced Graphene Oxide. Nanomaterials 2020, 10, 499. https://doi.org/10.3390/nano10030499
Jiao J, Pan M, Liu X, Liu J, Li B, Chen Q. An Ultrasensitive Non-Enzymatic Sensor for Quantitation of Anti-Cancer Substance Chicoric Acid Based on Bimetallic Nanoalloy with Polyetherimide-Capped Reduced Graphene Oxide. Nanomaterials. 2020; 10(3):499. https://doi.org/10.3390/nano10030499
Chicago/Turabian StyleJiao, Jun, Meixin Pan, Xinran Liu, Jian Liu, Binshuai Li, and Qiang Chen. 2020. "An Ultrasensitive Non-Enzymatic Sensor for Quantitation of Anti-Cancer Substance Chicoric Acid Based on Bimetallic Nanoalloy with Polyetherimide-Capped Reduced Graphene Oxide" Nanomaterials 10, no. 3: 499. https://doi.org/10.3390/nano10030499
APA StyleJiao, J., Pan, M., Liu, X., Liu, J., Li, B., & Chen, Q. (2020). An Ultrasensitive Non-Enzymatic Sensor for Quantitation of Anti-Cancer Substance Chicoric Acid Based on Bimetallic Nanoalloy with Polyetherimide-Capped Reduced Graphene Oxide. Nanomaterials, 10(3), 499. https://doi.org/10.3390/nano10030499