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10.3390/nano11071850
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Article

pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release

by
Jean Schoeller
1,2,
Fabian Itel
1,
Karin Wuertz-Kozak
3,4,
Sandra Gaiser
5,
Nicolas Luisier
1,
Dirk Hegemann
5,
Stephen J. Ferguson
2,
Giuseppino Fortunato
1,† and
René M. Rossi
1,2,*
1
Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Biomimetic Membranes and Textiles, 9014 St. Gallen, Switzerland
2
Institute for Biomechanics, ETH Zürich, 8093 Zürich, Switzerland
3
Schoen Clinic Munich Harlaching, Spine Center, Academic Teaching Hospital and Spine Research Institute of the Paracelsus Medical University Salzburg (AU), 81547 Munich, Germany
4
Department of Biomedical Engineering, Rochester Institute of Technology (RIT), Rochester, NY 14607, USA
5
Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Advanced Fibers, 9014 St. Gallen, Switzerland
*
Author to whom correspondence should be addressed.
†
This author passed away in June 2020.
Nanomaterials 2021, 11(7), 1850; https://doi.org/10.3390/nano11071850
Submission received: 1 June 2021 / Revised: 2 July 2021 / Accepted: 7 July 2021 / Published: 17 July 2021
(This article belongs to the Special Issue Functionalization of Electrospun Nanofibers in Bioengineering)
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Abstract

The surface functionalization of electrospun nanofibers allows for the introduction of additional functionalities while at the same time retaining the membrane properties of high porosity and surface-to-volume ratio. In this work, we sequentially deposited layers of chitosan and alginate to form a polyelectrolyte complex via layer-by-layer assembly on PLGA nanofibers to introduce pH-responsiveness for the controlled release of ibuprofen. The deposition of the polysaccharides on the surface of the fibers was revealed using spectroscopy techniques and ζ-potential measurements. The presence of polycationic chitosan resulted in a positive surface charge (16.2 ± 4.2 mV, pH 3.0) directly regulating the interactions between a model drug (ibuprofen) loaded within the polyelectrolyte complex and the layer-by-layer coating. The release of ibuprofen was slowed down in acidic pH (1.0) compared to neutral pH as a result of the interactions between the drug and the coating. The provided mesh acts as a promising candidate for the design of drug delivery systems required to bypass the acidic environment of the digestive tract.
Keywords: electrospinning; pH-responsive; drug delivery; surface functionalization; layer-by-layer; natural polymers; surface charge; oral delivery electrospinning; pH-responsive; drug delivery; surface functionalization; layer-by-layer; natural polymers; surface charge; oral delivery

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MDPI and ACS Style

Schoeller, J.; Itel, F.; Wuertz-Kozak, K.; Gaiser, S.; Luisier, N.; Hegemann, D.; Ferguson, S.J.; Fortunato, G.; Rossi, R.M. pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release. Nanomaterials 2021, 11, 1850. https://doi.org/10.3390/nano11071850

AMA Style

Schoeller J, Itel F, Wuertz-Kozak K, Gaiser S, Luisier N, Hegemann D, Ferguson SJ, Fortunato G, Rossi RM. pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release. Nanomaterials. 2021; 11(7):1850. https://doi.org/10.3390/nano11071850

Chicago/Turabian Style

Schoeller, Jean, Fabian Itel, Karin Wuertz-Kozak, Sandra Gaiser, Nicolas Luisier, Dirk Hegemann, Stephen J. Ferguson, Giuseppino Fortunato, and René M. Rossi. 2021. "pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release" Nanomaterials 11, no. 7: 1850. https://doi.org/10.3390/nano11071850

APA Style

Schoeller, J., Itel, F., Wuertz-Kozak, K., Gaiser, S., Luisier, N., Hegemann, D., Ferguson, S. J., Fortunato, G., & Rossi, R. M. (2021). pH-Responsive Chitosan/Alginate Polyelectrolyte Complexes on Electrospun PLGA Nanofibers for Controlled Drug Release. Nanomaterials, 11(7), 1850. https://doi.org/10.3390/nano11071850

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