A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chemicals
2.2. SPR-LDF Sensor System: Fabrication Steps and Experimental Setup
2.3. NanoMIP Synthesis and LDF-SPR Functionalization Process
3. Results and Discussion
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sensor | K [fM] | Statistics | ||||||
---|---|---|---|---|---|---|---|---|
NanoMIPs combined with SPR-LDF sensor | Value | Standard error | Value | Standard error | Value | Standard error | Reduced Chi-Sqr | Adj. R-square |
0.97 | 1.03 | 10.22 | 0.13 | 12.87 | 3.05 | 1.19 | 0.99 |
Sensor | Parameters | Value |
---|---|---|
SPR-LDF sensor combined with NanoMIPs | Kaff [fM−1] (Kaff = 1/K) | 0.08 |
Sensitivity at low c [nm/fM] | 0.72 | |
LOD [fM] | 4.3 |
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Arcadio, F.; Seggio, M.; Del Prete, D.; Buonanno, G.; Mendes, J.; Coelho, L.C.C.; Jorge, P.A.S.; Zeni, L.; Bossi, A.M.; Cennamo, N. A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins. Nanomaterials 2022, 12, 1400. https://doi.org/10.3390/nano12091400
Arcadio F, Seggio M, Del Prete D, Buonanno G, Mendes J, Coelho LCC, Jorge PAS, Zeni L, Bossi AM, Cennamo N. A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins. Nanomaterials. 2022; 12(9):1400. https://doi.org/10.3390/nano12091400
Chicago/Turabian StyleArcadio, Francesco, Mimimorena Seggio, Domenico Del Prete, Gionatan Buonanno, João Mendes, Luís C. C. Coelho, Pedro A. S. Jorge, Luigi Zeni, Alessandra Maria Bossi, and Nunzio Cennamo. 2022. "A Plasmonic Biosensor Based on Light-Diffusing Fibers Functionalized with Molecularly Imprinted Nanoparticles for Ultralow Sensing of Proteins" Nanomaterials 12, no. 9: 1400. https://doi.org/10.3390/nano12091400