Iron Oxide Nanoparticles as Promising Antibacterial Agents of New Generation
Abstract
:1. Introduction
2. Antibacterial Potential Mechanisms of IONPs
3. Structure of IONPs
4. Main Factors Influencing the Antibacterial Activity of IONPs
5. Main Factors Influencing the Biodistribution of IONPs
Type | Size (nm) | Shape | Surface Charge | MIC (µg/mL) | MBC (µg/mL) | Bacteria | Ref. |
---|---|---|---|---|---|---|---|
Chitosan-Fe3O4 | 10–20 | Spherical | Positive | NR NR | NR NR | E. coli B. subtilis | [54] |
PVA-Fe2O3/Fe3O4 | 9 ± 4 | Spherical | Negative | NR | NR | S. aureus | [68] |
Amine-Fe3O4 | 6–15 | Spherical | Negative | NR NR | NR NR | S. aureus E. coli | [69] |
Arg-Fe3O4 | 6–15 | Spherical | Negative | NR | NR | S. aureus | |
APTMS -Fe3O4 | 6–15 | Spherical | Positive | 125 125 | NR NR | S. aureus E. coli | |
Oleic acid-Fe3O4 | 6–15 | Spherical | Negative | 31 63 | NR NR | S. aureus E. coli | |
Fe3O4 @PEG-Ag | 20–25 | Spherical | NR | 16 16 | 32 32 | E. coli S. aureus | [70] |
Fe3O4@Ag | 60 ± 20 | Spherical | NR | ≥70 ≥60 ≥70 | NR NR NR | E. coli S. epidermidis B. subtilis | [71] |
CES-Fe3O4 | 13.8 ± 2.1 | Spherical | Negative | NR NR | NR NR | S. aureus S epidermidis | [72] |
APTES-Fe3O4 | 17.8 ± 2.6 | Spherical | Positive | NR NR | NR NR | S. aureus S epidermidis | |
Fe3O4 | 13.7 ± 2.1 | Spherical | Positive | NR NR | NR NR | S. aureus S epidermidis | |
TEPSA-Fe3O4 | 12.1 ± 0.5 | Spherical | Negative | NR | NR | [55] | |
TPED-Fe3O4 | 11.4 ± 0.4 | Spherical | Positive | NR | NR | S. mutans Biofilm | |
Fe3O4 | 10.1 ± 0.6 | Spherical | Positive | NR | NR | ||
Fe3O4@APTES | 17 | Spherical | Positive | NR | NR | B. subtilis biofilm | [73] |
Fe2O3 | 35.16 ± 1.47 | Spherical | NR | NR NR NR NR | 65 ± 1.5 120 ± 2.3 80 ± 1.5 78 ± 1.4 | E. coli P. aeruginosa S. aureus B. subtilis | [74] |
α-Fe2O3 | 20–30 | Spherical | Positive | >150 >150 | NR NR | V. cholerae E. coli | [75] |
CEL/γ-Fe2O3/Ag | 15–20 | NR | NR | 512 1024 | 1024 1024 | S. aureus E. coli | [76] |
FeO | 20–80 | Rod | Negative | NR | NR | E. coli K. pneumoniae S. aureus | [77] |
6. Biocompatibility of IONPs
7. Disadvantages of IONPs
8. Approaches for Increasing the Antibacterial Effect of IONPs
9. Conclusions
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Method | Nanoparticle Type | Bacteria | Ref. |
---|---|---|---|
External magnetic field | Mesoporous hollow Fe3O4 | E. coli S. aureus | [85] |
Hydroxyapatite-Fe3O4 | S. aureus E. coli | [86] | |
SPION-encapsulating polymersome | S. epidermidis biofilms | [87] | |
Fe3O4@Ag@Hydroxyapatite | S. aureus biofilms | [88] | |
Foreign metal doping | Ag-doped α-Fe2O3 | S. aureus Bacillus Klebsiella E. col | [89] |
Ni-doped Fe3O4/ZnO | S. aureus K. pneumoniae | [90] | |
Au-doped Fe3O4 | A. baumannii S. enterica S. aureus M. luteus | [91] | |
Surface modification | Oleic acid-Fe3O4 | S. aureus E. coli | [69] |
Chitosan-Fe3O4 | B. subtilis E. coli | [54] | |
β-glucan-Fe2O3 | E. coli. | [92] | |
Fe3O4@QSM-CIP | B. cereus E. coli S. typhimurium S. aureus | [93] |
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Zhang, T.-G.; Miao, C.-Y. Iron Oxide Nanoparticles as Promising Antibacterial Agents of New Generation. Nanomaterials 2024, 14, 1311. https://doi.org/10.3390/nano14151311
Zhang T-G, Miao C-Y. Iron Oxide Nanoparticles as Promising Antibacterial Agents of New Generation. Nanomaterials. 2024; 14(15):1311. https://doi.org/10.3390/nano14151311
Chicago/Turabian StyleZhang, Tian-Guang, and Chao-Yu Miao. 2024. "Iron Oxide Nanoparticles as Promising Antibacterial Agents of New Generation" Nanomaterials 14, no. 15: 1311. https://doi.org/10.3390/nano14151311