Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Synthesis Methods
2.2.1. Synthesis of Fe3O4@CEF Nanoparticles
2.2.2. Synthesis of PLGA/Fe3O4@CEF Coatings
2.3. Physicochemical Characterisation
2.3.1. Grazing Incidence X-ray Diffraction (GIXRD)
2.3.2. Thermogravimetric Analysis (TGA)
2.3.3. Transmission Electron Microscopy (TEM)
2.3.4. Infrared Microscopy (IRM)
2.4. Biological Evaluation
2.4.1. Biocompatibility Evaluation
2.4.2. Antimicrobial Evaluation
Antimicrobial Evaluation of the Core-Shell Nanoparticles
Anti-Biofilm Effect of the Coatings
2.4.3. In Vivo Biocompatibility and Biodistribution
3. Results
3.1. Physicochemical Characterisation of Fe3O4@CEF Nanoparticles
3.2. Physicochemical Characterisation of PLGA/Fe3O4@CEF Coatings
3.3. Biological Evaluation of the PLGA/ Fe3O4@CEF Coatings
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Ficai, D.; Grumezescu, V.; Fufă, O.M.; Popescu, R.C.; Holban, A.M.; Ficai, A.; Grumezescu, A.M.; Mogoanta, L.; Mogosanu, G.D.; Andronescu, E. Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite. Nanomaterials 2018, 8, 633. https://doi.org/10.3390/nano8090633
Ficai D, Grumezescu V, Fufă OM, Popescu RC, Holban AM, Ficai A, Grumezescu AM, Mogoanta L, Mogosanu GD, Andronescu E. Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite. Nanomaterials. 2018; 8(9):633. https://doi.org/10.3390/nano8090633
Chicago/Turabian StyleFicai, Denisa, Valentina Grumezescu, Oana Mariana Fufă, Roxana Cristina Popescu, Alina Maria Holban, Anton Ficai, Alexandru Mihai Grumezescu, Laurentiu Mogoanta, George Dan Mogosanu, and Ecaterina Andronescu. 2018. "Antibiofilm Coatings Based on PLGA and Nanostructured Cefepime-Functionalized Magnetite" Nanomaterials 8, no. 9: 633. https://doi.org/10.3390/nano8090633