“Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy †
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Synthetic Procedures
2.2.1. Synthesis of Amino-Modified MSNs (MSNs-NH2)
2.2.2. Synthesis of the PS-Modified MSNs (PS-MSNs)
2.2.3. Synthesis of NOPD-Modified PS-MSNs (PS-MSNs-NOPD)
2.2.4. Stability of the PS-MSNs-NOPD
2.3. Instrumentation
2.4. Chemical Detection of NO
2.5. Chemical Detection of Singlet Oxygen
2.6. Loading and Release of DOX
2.7. Biological Assays
2.7.1. Cells Characterization
2.7.2. Viability Assays
2.7.3. Statistical Analysis
3. Results and Discussion
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Tessaro, A.L.; Fraix, A.; Pedrozo da Silva, A.C.; Gazzano, E.; Riganti, C.; Sortino, S. “Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy. Nanomaterials 2019, 9, 823. https://doi.org/10.3390/nano9060823
Tessaro AL, Fraix A, Pedrozo da Silva AC, Gazzano E, Riganti C, Sortino S. “Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy. Nanomaterials. 2019; 9(6):823. https://doi.org/10.3390/nano9060823
Chicago/Turabian StyleTessaro, André Luiz, Aurore Fraix, Ana Claudia Pedrozo da Silva, Elena Gazzano, Chiara Riganti, and Salvatore Sortino. 2019. "“Three-Bullets” Loaded Mesoporous Silica Nanoparticles for Combined Photo/Chemotherapy" Nanomaterials 9, no. 6: 823. https://doi.org/10.3390/nano9060823