Application of Nanoparticles and Nanomaterials in Thermal Ablation Therapy of Cancer
Abstract
:1. Introduction
2. Magnetic Nanoparticles (MNP)
3. Gold Nanoparticles (AuNP)
4. CuS Nanoparticles
5. Nanorods
6. Carbon Nanotubes (CNTs)
7. Nanoshells/Nanocomposites
7.1. Nanoshells
7.2. Nanocomposites
8. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Type of MNP/MNP with a Surface Coating | Nanoparticle Size | Injection Dose/Nanoparticle Concentration | Injection Route | Exposure Conditions | Thermal Ablation Type | Type of Tumor | Temperature, °C | Cell Death | Reference |
---|---|---|---|---|---|---|---|---|---|
Fe3O4 | 20–100 nm | 5 mg of Fe2O3 per gram of tissue | intratumoral | 200 to 240 oersteds, 3 min | RF ablation | dog’s lymph nodes | max 50 °C | N/A | [45] |
Fe3O4 | 50–100 nm | 5 mg of Fe2O3 per gram of tissue | intratumoral | 55,000 cycles/second, 500 oesterds, 30 min | RF ablation | lymph node metastases by | max 50 °C | N/A | [46] |
Fe3O4 | 10–20 nm | 21 mg ± 9 of magnetite per 299 mm3 of tumor tissue | intratumoral | 1.2–6.5 kA/m; 400 kHz, 242 s | AMF | human breast tissue | max 79 °C | N/A | [53] |
Fe3O4 | 10 nm | 5 ± 0.3 mg magnetite per 100 mg of tumor tissue | intratumoral | 400 kHz, 6.5 kA/m, 4 min | AMF | human breast adenocarcinoma cells | max 73 °C at tumor center and 12 °C at tumor periphery | N/A | [20] |
Fe3O4—dextran coated | 10–20 nm | 107 pg/cells | intratumoral | 410 kHz, 10 kA/m, 242 s | AMF | human breast adenocarcinoma cells | max 71 °C at tumor center | N/A | [54] |
Fe3O4—starch coated | 11.4 nm ± 0.38 | 0.32 mg Fe mL−1 culture medium | intratumoral | 400 kHz, 24.6 kA m−1 | AMF | breast carcinoma cell line BT474 | to 28.2 ± 0.4 °C | N/A | [51] |
Fe3O4—amino-silane coated | 15 nm | N/A | intratumoral | 100 kHz, 0–18 kA/m | AMF | RG-2 glioma cells | max 43–47 °C | N/A | [55] |
Fe3O4 | 20 nm | 11.4 mL per 100 mg of tumor tissue | interstitial | 100 kHz, 2.5–15 kA/m | AMF | prostate cancer | max 55 °C | N/A | [57] |
Fe3O4—amino-silane coated | 15 nm | 112 mg/mL | transperineally | 100 kHz, 2.5–18.0 kA/m, 60 min | AMF | prostate cancer | max 50 °C | N/A | [56] |
Fe3O4—amino-silane coated | 15 nm | 200–400 µl of MNP per 0.5 mL/cm3 tumor volume and 120 mg/mL | intratumoral | 100 kHz, 18.0 kA/m | AMF | prostate cancer | max 54.88 °C centrally and 41.28 °C—peripherally | N/A | [58] |
Type of NP/NP with a Surface Coating | Nanoparticle Size | Injection Dose/Nanoparticle Concentration | Injection Route | Exposure Conditions | Thermal Ablation Type | Type of Tumor | Temperature, °C | Cell Death | Reference |
---|---|---|---|---|---|---|---|---|---|
AuNP—anti-EGFR antibody coated | 40 nm | N/A | intratumoral | 57 W/cm2, 514 nm, 4 min | Laser photothermal therapy | Epithelial carcinoma HaCaT cells | N/A | 100% | [72] |
AuNP—citrate coated | 13 nm | N/A | intratumoral | 10–100 W, 7 min | Radiowave ablation | HepG2 cancerous cells | >50 °C | 80% | [73] |
AuNP | 5 nm | 67 µM/L | intratumoral | 13.56 MHz, 5 min | RF ablation | Hepatocellular (Hep3B) and Pancreatic cancerous cells (Panc-1) | N/A | 99.8 ± 3.1 Hep3B 96.5 ± 8.4 Panc-1 | [74] |
AuNP—anti-EGFR coated | N/A | N/A | intratumoral | 200 nW | Laser photothermal therapy | Cancerous cell | 70–80 °C | N/A | [69] |
AuNP—anti-EGFR coated | 20 nm | N/A | intratumoral | 13.56 MHz, 200 S, 10−15 kV/m | RF ablation | Pancreatic cancerous cell line | N/A | Panc-1 61% | [76] |
AuNP—PAM4 hemi-antibody coated and AuNP—C225 antibody-coated | 36.9 ± 1.5 nm 32.6 ± 0.7 nm | 100 µg/mL | invivo | 600 W, 10 min | RF ablation | Panc-1 and Capan-1 pancreatic carcinoma cell lines | N/A | N/A | [75] |
Type of Nanoparticle/Nanoparticle with a Surface Coating | Nanoparticle Size | Injection Dose/Nanoparticle Concentration | Injection Route | Exposure Conditions | Thermal Ablation Type | Type of Tumor | Cell Death | Temperature, °C | Reference |
---|---|---|---|---|---|---|---|---|---|
Thioglycolic acid-stabilized CuS NPs | 3 nm | 4.6 g/cm3, 770 µM | intratumoral | 24 W/cm2 for 5 min | photothermal ablation | HeLa cells | 55.6 ± 5.8% | Increased to 12.7 °C | [79] |
Chitosan-coated HCuSNPs | 10 × 12 nm | intratumoral | photothermal ablation | [81] | |||||
Phospholipid-PEG coated– CuS NPs | 3.8 nm | 400 mg/mL−1 | intratumoral | 1.0 W cm2, 8 min | Photothermal ablation | HeLa cells | >80% | Max 59.2 °C | [82] |
PEG coated—CuS NP | N/A | 400 mg/mL, 0.1 mm | intratumoral | 2.5 W/cm2 | Photothermal ablation | Anaplastic thyroid carcinoma | N/A | Max 98 °C | [83] |
Type of Nanorods/Nanorods with a Surface Coating | Nanorod Size/Concentration | Injection Dose/Nanorods Concentration | Injection Rote | Exposure Conditions | Thermal Ablation Type | Type of Tumor | Cell Death | Temperature, °C | Reference |
---|---|---|---|---|---|---|---|---|---|
AuNP | 5 nm | 0.001% volume fraction | intratumoral | 1.25 W/cm2, 300 s | photothermal therapy | Skin tumor | Total cell death | 75 °C at tumor surface, 43–48 °C at tumor depth | [93] |
PEGylated gold nanorods– C225 antibody | 3 mm | 4 mg/mL | intratumoral | 20 W/cm2 to 90 W/cm2, from 30 s to 3 min | photothermal laser ablation | HTB-9 cells | N/A | N/A | [94] |
PEGylated gold nanorods | dimensions 12 nm in width and 50 nm in length | N/A | intravenous | 3 min | photothermal therapy | HSC-3 human squamous carcinoma cells | >90% | N/A | [97] |
PEG-coated gold nanorods | N/A | N/A | intratumoral | 2 W cm–2, 5 min. | photothermal ablation | Cancer tumor | N/A | 50–52 °C | [98] |
gold nanorods | N/A | N/A | intratumoral | 30 J/cm2, 30 s | photothermal laser ablation | human KB cells | N/A | Increased by 5 °C | [86] |
PEG-coated gold nanorods | N/A | 20 mg Au/kg in PBS | intravenous | 2 W cm–2, 5 min | photothermal ablation | MDA-MB-435 human cancerouscells | Within 10 days all the irradiated, PEG-NR-targeted tumors completely disappeared | over 70 °C | [91] |
gold nanorods | N/A | N/A | intratumoral | 20 W/cm2, 4 to 20 min | photothermal ablation | prostate cancerouscells | N/A | N/A | [92] |
gold nanorods | N/A | N/A | intratumoral | 1.4 and 2 W/cm2, and 0.5, 1, 2, and 5 min | photothermal ablation | MDA-MB-231 human breast cancerous cells | N/A | About 55 °C | [95,96] |
Type of Carbon Nanotubes/Carbon Nanotubes with a Surface Coating | Carbon Nanotube Size | Injection Dose/Carbon Nanotube Concentration | Injection Route | Exposure Conditions | Thermal Ablation Type | Type of Tumor | Cell Death | Temperature, °C | Reference |
---|---|---|---|---|---|---|---|---|---|
SWNT–polymer coated | N/A | 50 mg/mL | intratumoral | 600 W, 13.56 MHz | RF ablation | human cancer cell lines (HepG2, Hep3B and Panc-1 | 100% | Increase by 1.6 °C per second | [114] |
Carbon nanotube—anti-Her2+ antibody coated | N/A | N/A | intratumoral | 9.5 W cm−2, 4 min | laser ablation | Her2+ human breast carcinoma cancer cells | 90% | N/A | [115] |
Carbon nanotube—(KFKA)7 –peptide coated | N/A | 0.75 μg/mL for colon26 cells 2.5 μg/mL for HepG2 cells | intratumoral | 30 s | photothermal therapy | Colon and HepG2 cells | N/A | 43 °C | [116] |
Multi-walled carbon nanotube | 900 nm | N/A | intratumoral | 15.3 W/cm2, 5 min | laser ablation | prostate cancer cell line (PC3) and murine renal cancer cell line (RENCA) | N/A | 43 °C | [117] |
Carbon nanotube— human albumin protein coated | N/A | N/A | Ex vivo | 5 W/cm2, 20 min | laser-mediated ablation | pancreatic cancer Panc-1 cells | N/A | 29.3 °C at tumor centre | [118] |
Type of Nanoshells/Nanocomposites (Core/Shell) | Size and/or Core/Shell Thickness | Injection Dose/Concertation | Injection Route | Exposure Conditions | Thermal Ablation Type | Type of Tumor | Temperature, °C | Cell Death | Reference |
---|---|---|---|---|---|---|---|---|---|
Gold nanoshells (silica/gold) | 110 nm/10 nm | N/A | intratumoral | 35 W/cm2, 7 min | photothermal therapy | breast cancer SK-BR-3 cells | >37.4 °C | N/A | [119] |
Gold nanoshells (gold/PEG) | 110 nm/8–10 nm | 100 µL of 2.4 × 1011 nanoshells/mL solution | intratumoral | 10 days | laser ablation | CT26.WT murine colon carcinoma tumor cells | 50 °C | 100% | [121] |
Gold nanoshells (silica/gold) | 110 ± 11 nm/10 nm | 8.5 µL/gm body weight | intratumoral | 21 days | NIR laser ablation | prostate cancer tumor | 65.4 °C | 93% | [126] |
anti-HER2—silica core nanoshell anti-IL13Ra2 antibody—silica core nanoshell (silica/gold) | 100 nm and 10 nm | 32.61 and 48.52 mg/g | intratumoral | N/A | photothermal ablation | medulloblastoma and glioma cell lines | N/A | 100% | [126] |
Gold nanoshells (silica/gold) | 150 nm | N/A | intratumoral | 3.5 W for 3 min | laser ablation | canine prostate cancer | N/A | 100% | [128] |
Graphitic carbon coated C–Co-NPs | 7 nm | 20 μg mL−1 | intratumoral | 350 kHz, 5 kW, 10 min | RF ablation | HeLa cells | N/A | 98% | [129] |
Fe3O4 nanoparticles– silica shell (silica/Fe3O4) | N/A | 1.66 µg/mL | intratumoral | 350 kHz, 10 min | RF ablation | Panc-1 cell line | N/A | 98.7– 99.2% | [131] |
GO-IONP-Au-PEG | N/A | 50 mg/mL | intratumoral | 0.75 W/cm2, 5 min | Laser ablation | 4T1 tumor cells | Max 55 °C | N/A | [132] |
Type of Nanoparticles/Source of Ablation | RF | MW | Laser Ablation | Photothermal Ablation |
---|---|---|---|---|
Magnetic nanoparticle | ||||
Gold nanoparticle | ||||
Cu-based nanoparticle | ||||
Nanorod | ||||
Carbon nanotubes | ||||
Nanoshell/Nanocomposite |
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Ashikbayeva, Z.; Tosi, D.; Balmassov, D.; Schena, E.; Saccomandi, P.; Inglezakis, V. Application of Nanoparticles and Nanomaterials in Thermal Ablation Therapy of Cancer. Nanomaterials 2019, 9, 1195. https://doi.org/10.3390/nano9091195
Ashikbayeva Z, Tosi D, Balmassov D, Schena E, Saccomandi P, Inglezakis V. Application of Nanoparticles and Nanomaterials in Thermal Ablation Therapy of Cancer. Nanomaterials. 2019; 9(9):1195. https://doi.org/10.3390/nano9091195
Chicago/Turabian StyleAshikbayeva, Zhannat, Daniele Tosi, Damir Balmassov, Emiliano Schena, Paola Saccomandi, and Vassilis Inglezakis. 2019. "Application of Nanoparticles and Nanomaterials in Thermal Ablation Therapy of Cancer" Nanomaterials 9, no. 9: 1195. https://doi.org/10.3390/nano9091195