Association between Glycosylated Hemoglobin Levels and Vaccine Preventable Diseases: A Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Inclusion and Exclusion Criteria
- P: Adult population (≥18 years) with or without vaccine-preventable diseases (VPDs) at the baseline;
- I: Higher HbA1c values;
- C: lower HbA1c values;
- O: Mortality and hospitalization rates in patients with VPDs and incidence of VPDs in people without VPDs at the baseline;
- S: Both prospective and retrospective observational studies.
2.3. Data Extraction and Risk of Bias
2.4. Statistical Analysis
3. Results
3.1. Literature Search
3.2. Descriptive Data
3.3. Main Findings
3.4. Risk of Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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Author | Year | Country | Type of Study | VPD Considered | Follow-Up (Months) | Total Sample Size | % of Females | Mean Age | Outcome | Confounders Mentioned in the Multivariate Analysis (Number) |
---|---|---|---|---|---|---|---|---|---|---|
Bo-Lin Pan [35] | 2022 | China | Prospective cohort study | HZ | 72 | 121,999 | 46.3 | 60.4 | Incidence of HZ | Age, sex, comorbidities (3) |
Kobayashi D [33] | 2019 | Japan | Retrospective longitudinal study | HZ | 132 | 81,466 | 51.3 | 46.5 | Incidence of HZ | Age, sex, time variable; social histories, including smoking status, alcohol consumption, BMI, and exercise habits; history of diabetes and its pharmacological treatment status, medical histories, including cancer, autoimmune disease, hemodialysis, and chronic hepatitis/cirrhosis (13) |
De Jong M [34] | 2021 | UK | Prospective cohort study | COVID-19 | 134 | 501,884 | 54 | Aged 40–69 years at baseline | Death from COVID-19 | Age, BMI, socioeconomic status, smoking, systolic blood pressure, total cholesterol, antihypertensivemedication, glucose-loweringmedication, lipid lowering medication (9) |
TOTAL | Two prospective; one retrospective | 113 | 705,349 | 54 | Two: HZ; one: COVID-19 | 8 |
Author | Year | Main Findings |
---|---|---|
Bo-Lin Pan et al. [35] | 2022 | Four HbA1C trajectories were identified: ‘good control’ (mean HbA1C of 6.7% or 50 mmol/mol), ‘high decreasing’ (mean HbA1C of 7.9% or 63 mmol/mol), ‘moderate control’ (mean HbA1C of 8.4% or 68 mmol/mol), and ‘poor control’ (mean HbA1C of 10.7% or 93 mmol/mol). A significantly higher risk of HZ was observed in the ‘poor control’ trajectory with an HR = 1.44 (95% CI 1.26–1.64) after adjusting for confounders and comorbidities. |
Kobayashi D [33] | 2019 | Individuals in the lowest HbA1c group (HbA1c of <5.0%) exhibited a significantly higher risk of developing HZ (OR 1.63; 95%CI: 1.07–2.48) compared with the reference group (HbA1c of 5.0–6.4%). Individuals in the highest HbA1c group (HbA1cof ≥ 9.5%) had a higher but nonsignificant risk than the reference group (OR 2.15; 95% CI, 0.67–6.94). |
De Jong M [34] | 2021 | There was no association between higher levels of HbA1c and increased risk of COVID-19 or influenza/pneumonia death in women. On the contrary, compared with no diabetes, an HbA1c > 7.5% (58 mmol/mol) was associated with an increased risk of COVID-19 or influenza/pneumonia death in men. |
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De Vita, E.; Limongi, F.; Veronese, N.; Di Gennaro, F.; Saracino, A.; Maggi, S. Association between Glycosylated Hemoglobin Levels and Vaccine Preventable Diseases: A Systematic Review. Diseases 2024, 12, 187. https://doi.org/10.3390/diseases12080187
De Vita E, Limongi F, Veronese N, Di Gennaro F, Saracino A, Maggi S. Association between Glycosylated Hemoglobin Levels and Vaccine Preventable Diseases: A Systematic Review. Diseases. 2024; 12(8):187. https://doi.org/10.3390/diseases12080187
Chicago/Turabian StyleDe Vita, Elda, Federica Limongi, Nicola Veronese, Francesco Di Gennaro, Annalisa Saracino, and Stefania Maggi. 2024. "Association between Glycosylated Hemoglobin Levels and Vaccine Preventable Diseases: A Systematic Review" Diseases 12, no. 8: 187. https://doi.org/10.3390/diseases12080187