Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models
Abstract
:1. Introduction
2. Establishments of Rodent Carcinogenesis Models
2.1. Establishment of Chemical Carcinogenesis Model
2.2. Establishment of H. pylori Infection Models
3. Mechanisms of Gastric Carcinogenesis in Vivo
3.1. Use of Inhibitors
3.1.1. Antioxidants
3.1.2. COX-2 Inhibitors
3.1.3. NF-κB inhibitors
3.1.4. Statins
3.2. Use of Genetically-Modified Animals
3.2.2. COX-2/Prostaglandin
3.2.3. Wnt/β-Catenin
3.2.4. Proinflammatory Cytokines
3.2.5. Gastrin
3.2.6. Type III Mucin
3.3. Microarray and Epigenetics
3.3.1. Microarray
3.3.2. Epigenetics
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Toyoda, T.; Yamamoto, M.; Takasu, S.; Ogawa, K.; Tatematsu, M.; Tsukamoto, T. Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models. Diseases 2014, 2, 168-186. https://doi.org/10.3390/diseases2020168
Toyoda T, Yamamoto M, Takasu S, Ogawa K, Tatematsu M, Tsukamoto T. Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models. Diseases. 2014; 2(2):168-186. https://doi.org/10.3390/diseases2020168
Chicago/Turabian StyleToyoda, Takeshi, Masami Yamamoto, Shinji Takasu, Kumiko Ogawa, Masae Tatematsu, and Tetsuya Tsukamoto. 2014. "Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models" Diseases 2, no. 2: 168-186. https://doi.org/10.3390/diseases2020168