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Article
Peer-Review Record

Body Adiposity Partially Mediates the Association between FTO rs9939609 and Lower Adiponectin Levels in Chilean Children

Children 2023, 10(3), 426; https://doi.org/10.3390/children10030426
by Carolina Ochoa-Rosales 1,2, Lorena Mardones 3, Marcelo Villagrán 3, Claudio Aguayo 4, Miquel Martorell 2,5, Carlos Celis-Morales 6,7,8 and Natalia Ulloa 2,4,*
Reviewer 1:
Reviewer 2:
Children 2023, 10(3), 426; https://doi.org/10.3390/children10030426
Submission received: 18 January 2023 / Revised: 13 February 2023 / Accepted: 20 February 2023 / Published: 22 February 2023
(This article belongs to the Special Issue Metabolic and Nutritional Diseases in Children)

Round 1

Reviewer 1 Report

-acronym in the abstract should be avoided

- the abstract is not informative, it is not clear wether authors recruited children, how many, the methods etc.

- the great limitation of the study is that the authors cannot exclude that adiponectin modulation is due to polymorphisms in ADIPOQ gene

- inclusion and exclusion criteria should be specified 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

The entire manuscript would benefit significantly from a grammatical revision.

There is an error in participants' age range, i.e, in the abstract it stated, children aged 6–11 years but in the "Study Design and Population" section it stated as 7 to 11 years old.

It left me bewildered.

The authors should consider the potential confounders in their statistical analysis, such as genetic ancestry.

It is necessary that the authors describe the detail of band length for SNP with added a PCR product figure.

A part of the samples must be sequenced and shown in figure. 

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

the authors have improved the manuscript appropriately

Reviewer 2 Report

Accept in current form

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