Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment

Choudhary, Sahar; Singh, Mithalesh Kumar; Kashyap, Seema; Seth, Rachna; Singh, Lata

doi:10.3390/children11060700

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Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment

by

Sahar Choudhary

¹,

Mithalesh Kumar Singh

^2,*

,

Seema Kashyap

³,

Rachna Seth

¹ and

Lata Singh

^1,*

¹

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India

²

Department of Ophthalmology, UT Southwestern Medical Center, Dallas, TX 75390, USA

³

Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi 110029, India

^*

Authors to whom correspondence should be addressed.

Children 2024, 11(6), 700; https://doi.org/10.3390/children11060700

Submission received: 16 April 2024 / Revised: 29 May 2024 / Accepted: 3 June 2024 / Published: 7 June 2024

(This article belongs to the Section Pediatric Hematology & Oncology)

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Abstract

The evolutionarily conserved Wnt signaling has a significant and diverse role in maintaining cell homeostasis and tissue maintenance. It is necessary in the regulation of crucial biological functions such as embryonal development, proliferation, differentiation, cell fate, and stem cell pluripotency. The deregulation of Wnt/β-catenin signaling often leads to various diseases, including cancer and non-cancer diseases. The role of Wnt/β-catenin signaling in adult tumors has been extensively studied in literature. Although the Wnt signaling pathway has been well explored and recognized to play a role in the initiation and progression of cancer, there is still a lack of understanding on how it affects pediatric tumors. This review discusses the recent developments of this signaling pathway in pediatric tumors. We also focus on understanding how different types of variations in Wnt signaling pathway contribute to cancer development and provide an insight of tissue specific mutations that lead to clinical progression of these tumors.

Keywords: Wnt signaling pathway; neuroblastoma; rhabdomyosarcoma; retinoblastoma; Wilms tumor; targeted therapies

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MDPI and ACS Style

Choudhary, S.; Singh, M.K.; Kashyap, S.; Seth, R.; Singh, L. Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment. Children 2024, 11, 700. https://doi.org/10.3390/children11060700

AMA Style

Choudhary S, Singh MK, Kashyap S, Seth R, Singh L. Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment. Children. 2024; 11(6):700. https://doi.org/10.3390/children11060700

Chicago/Turabian Style

Choudhary, Sahar, Mithalesh Kumar Singh, Seema Kashyap, Rachna Seth, and Lata Singh. 2024. "Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment" Children 11, no. 6: 700. https://doi.org/10.3390/children11060700

APA Style

Choudhary, S., Singh, M. K., Kashyap, S., Seth, R., & Singh, L. (2024). Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment. Children, 11(6), 700. https://doi.org/10.3390/children11060700

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment

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