Antibiotic Exposure of Critically Ill Children at a Tertiary Care Paediatric Intensive Care Unit in Switzerland
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Study Design
2.3. Variables
2.4. Endpoint Assessment
3. Results
4. Discussion
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Patient Characteristics | Value |
---|---|
Age (months) | 10.0 [0, 64] |
Age stratification | |
0–1 Month | 587 (28.8) |
>1–12 Months | 494 (24.2) |
>1–5 Years | 431 (21.1) |
>5–12 Years | 342 (16.8) |
>12 Years | 187 (9.2) |
Gender | |
Female | 952 (46.6) |
Male | 1089 (53.4) |
Treatment year | |
2019 | 709 (34.7) |
2020 | 658 (32.2) |
2021 | 674 (33.0) |
DOT (days) | 2.0 [0.5, 4.5] |
PIM II (%) | 1.98 [0.02, 4.86] |
LOS (days) | 2.73 [0.07, 5.90] |
LOS | |
0–2 days | 902 (44.19) |
>2–7 days | 650 (31.85) |
>7 days | 489 (23.96) |
Death | |
No | 1950 (95.5) |
Yes | 91 (4.5) |
Diagnosis 1 | |
Respiratory | 388 (19.01) |
Cardiac | 200 (9.8) |
Gastrointestinal | 50 (2.45) |
Renal | 24 (1.18) |
Neurologic | 131 (6.42) |
Trauma | 34 (1.67) |
Postinterventional | 1006 (49.29) |
Miscellaneous | 208 (10.19) |
Class of antibiotic (%) 2 | |
Penicillin | 32.80 |
Cephalosporin | 21.94 |
Carbapenem | 14.23 |
Aminoglycoside | 10.53 |
Glycopeptide | 8.06 |
Sulfonamide/Diaminopyrimidine | 5.40 |
Other | 7.04 |
AWaRe classification (%) 3 | |
Access | 63.07 |
Watch | 36.86 |
Reserve | 0.04 |
Category | DOT/100pd |
---|---|
Overall | 59.8 |
Age stratification | |
0–1 Month | 72.7 |
>1–12 Months | 45.0 |
>1–5 Years | 65.0 |
>5–12 Years | 70.1 |
>12 Years | 62.6 |
Gender | |
Female | 60.8 |
Male | 59.1 |
Treatment year | |
2019 | 55.2 |
2020 | 59.8 |
2021 | 64.5 |
LOS | |
0–2 days | 47.0 |
>2–7 days | 65.1 |
>7 days | 60.6 |
Death | |
Yes | 91.5 |
No | 56.8 |
Diagnosis | |
Neurologic | 41.5 |
Cardiac | 58.4 |
Respiratory | 58.5 |
Trauma | 58.8 |
Postinterventional | 60.1 |
Miscellaneous | 61.9 |
Gastrointestinal | 92.5 |
Renal | 98.0 |
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Fenner, A.; Huber, M.; Gotta, V.; Jaeggi, V.; Schlapbach, L.J.; Baumann, P. Antibiotic Exposure of Critically Ill Children at a Tertiary Care Paediatric Intensive Care Unit in Switzerland. Children 2024, 11, 731. https://doi.org/10.3390/children11060731
Fenner A, Huber M, Gotta V, Jaeggi V, Schlapbach LJ, Baumann P. Antibiotic Exposure of Critically Ill Children at a Tertiary Care Paediatric Intensive Care Unit in Switzerland. Children. 2024; 11(6):731. https://doi.org/10.3390/children11060731
Chicago/Turabian StyleFenner, Anica, Melanie Huber, Verena Gotta, Vera Jaeggi, Luregn J. Schlapbach, and Philipp Baumann. 2024. "Antibiotic Exposure of Critically Ill Children at a Tertiary Care Paediatric Intensive Care Unit in Switzerland" Children 11, no. 6: 731. https://doi.org/10.3390/children11060731
APA StyleFenner, A., Huber, M., Gotta, V., Jaeggi, V., Schlapbach, L. J., & Baumann, P. (2024). Antibiotic Exposure of Critically Ill Children at a Tertiary Care Paediatric Intensive Care Unit in Switzerland. Children, 11(6), 731. https://doi.org/10.3390/children11060731