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Review

The Denominator Matters! Lessons from Large Database Research in Neonatology

1
Division of Neonatology, Baylor University Medical Center and Pediatrix Medical Group, Dallas, TX 75246, USA
2
The MEDNAX Center for Research, Education, Quality, and Safety, Sunrise, FL 33323, USA
*
Author to whom correspondence should be addressed.
Children 2020, 7(11), 216; https://doi.org/10.3390/children7110216
Submission received: 3 October 2020 / Revised: 2 November 2020 / Accepted: 5 November 2020 / Published: 7 November 2020
(This article belongs to the Special Issue Neonatal Health Care)

Abstract

Observational studies from large datasets are becoming more common in neonatology. In this review, we highlight the importance of the denominator in study design and interpretation including examples of bias from source data, weight-based categories, age-related bias, and diagnosis-based denominators.
Keywords: infants; infant; neonatal intensive care; health service research; statistics; study interpretation infants; infant; neonatal intensive care; health service research; statistics; study interpretation

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MDPI and ACS Style

Tolia, V.N.; Clark, R.H. The Denominator Matters! Lessons from Large Database Research in Neonatology. Children 2020, 7, 216. https://doi.org/10.3390/children7110216

AMA Style

Tolia VN, Clark RH. The Denominator Matters! Lessons from Large Database Research in Neonatology. Children. 2020; 7(11):216. https://doi.org/10.3390/children7110216

Chicago/Turabian Style

Tolia, Veeral N., and Reese H. Clark. 2020. "The Denominator Matters! Lessons from Large Database Research in Neonatology" Children 7, no. 11: 216. https://doi.org/10.3390/children7110216

APA Style

Tolia, V. N., & Clark, R. H. (2020). The Denominator Matters! Lessons from Large Database Research in Neonatology. Children, 7(11), 216. https://doi.org/10.3390/children7110216

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