Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy
Abstract
:1. Introduction
2. Methods
2.1. Study Population, Design, Location, and Period
2.2. Primary Outcome
2.3. Secondary Outcomes
2.4. Analysis Plan
2.5. Ethical Considerations
3. Results
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sample Characteristics | Study Groups | p Value a | |
---|---|---|---|
Any Human Milk Feeding, N = 260 | Exclusive Formula Feeding, N = 62 | ||
Gestational hypertension | 21 (80.7) | 6 (9.7) | 0.607 |
Gestational diabetes | 8 (3.0) | 2 (3.3) | 1.000 |
Chrioamnionitis | 63 (24.0) | 20 (32.2) | 0.218 |
Group B strep positive mother | 36 (13.8) | 5 (8.3) | 0.512 |
Gestational age, weeks | 38.59 (2.08) | 38.01 (2.27) | 0.056 |
Delivery type: vaginal/C-section | 72 (27.4) | (46.6) | 0.0052 ** |
Multiple gestation | 13 (4.9) | 7 (13.2) | 0.071 |
Apgar 1 min | 8 (2) | 7 (3) | 0.036 * |
Apgar 5 min | 9 (1) | 9 (2) | 1.000 |
Birth weight, g | 3116 (639) | 2893 (637) | 0.010 * |
Height, cm | 48.6 (2.84) | 48.22 (2.69) | 0.322 |
Cranial circumference, cm | 33.83 (2.02) | 33.37 (1.94) | 0.093 |
Girls/boys | 126/136 | 26/34 | 0.567 |
Any Human Milk Feeding N = 260 | Exclusive Formula Feeding, N = 62 | p Value a | |
---|---|---|---|
Apnea | 47 (18.0) | 17 (27.4) | 0.074 |
Abnormal alertness state | 143 (55.0) | 27 (43.5) | 0.198 |
Abnormal muscle tone | 118 (45.3) | 28 (45.1) | 0.886 |
Convulsions | 10 (3.8) | 4 (6.4) | 0.304 |
Hypotension | 43 (16.5) | 16 (25.8) | 0.094 |
Neonatal acidosis | 77 (29.6) | 24 (40.6) | 0.121 |
Positive blood culture, n (%) | 81 (31.1) | 18 (29.0) | 1.000 |
Meningitis | 20 (10.1) | 0/31 (0) | 0.084 |
Type of respiratory support | |||
- No support | 190 (72) | 34 (55) | |
- Oxygen therapy | 14 (5.3) | 3 (4.8) | |
- Noninvasive ventilation | 34 (13) | 4 (6.5) | |
- Invasive mechanical ventilation | 24 (9.2) | 19 (31) | 0.000067 *** |
Fraction of inspired Oxygen | 0.28 (0.16) | 0.39 (0.25) | 0.0001 ** |
Hospitalization, days | 10 (9) | 12 (9) | 0.121 |
Abnormal brain ultrasound | 13 (4.6) | 1 (1.9) | 0.482 |
Discharge weight, g | 3425 (689) | 3256 (639) | 0.083 |
Variable | Odds Ratio | Standard Error | z | p > |z| | 95% CI |
---|---|---|---|---|---|
Human milk feeding | 0.449 | 0.157 | −2.28 | 0.023 | 0.225 to 0.893 |
Weeks of gestation | 0.821 | 0.051 | −3.12 | 0.002 | 0.725 to 0.929 |
Sepsis score | 3.668 | 1.430 | 3.33 | 0.001 | 1.708 to 7.877 |
Abnormal alertness state | 1.576 | 0.334 | 2.15 | 0.032 | 1.040 to 2.388 |
Abnormal muscle tone | 3.239 | 1.089 | 3.49 | 0.000 | 1.675 to 6.261 |
Meningitis | 0.505 | 0.126 | −2.73 | 0.006 | 0.310 to 0.825 |
Abnormal brain ultrasound | 5.473 | 2.491 | 3.73 | 0.000 | 2.242 to 13.358 |
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Moliner-Calderón, E.; Verd, S.; Leiva, A.; Ponce-Taylor, J.; Ginovart, G.; Moll-McCarthy, P.; Gelabert, C.; Figueras-Aloy, J. Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy. Children 2022, 9, 1450. https://doi.org/10.3390/children9101450
Moliner-Calderón E, Verd S, Leiva A, Ponce-Taylor J, Ginovart G, Moll-McCarthy P, Gelabert C, Figueras-Aloy J. Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy. Children. 2022; 9(10):1450. https://doi.org/10.3390/children9101450
Chicago/Turabian StyleMoliner-Calderón, Elisenda, Sergio Verd, Alfonso Leiva, Jaume Ponce-Taylor, Gemma Ginovart, Pia Moll-McCarthy, Catian Gelabert, and Josep Figueras-Aloy. 2022. "Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy" Children 9, no. 10: 1450. https://doi.org/10.3390/children9101450