Recurrent Fever with Oral Lesions in Egyptian Children: A Familial Mediterranean Fever Diagnosis Not to Be Missed
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Patient Population
2.2. Laboratory Investigations
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Eurofever/PRINTO Classification Criteria |
---|
Presence of confirmatory MEFV genotype * and at least one among the following: ● Duration of episodes 1–3 days. ● Arthritis ● Chest pain ● Abdominal pain |
Or |
Presence of not confirmatory MEFV genotype † and at least two among the following: ● Duration of episodes 1–3 days. ● Arthritis ● Chest pain. ● Abdominal pain |
Demographic Data n (%) | |
---|---|
Age range of diagnosis Mean ± SD (Years) | (10 months–10 years) 3.5 ± 1.55805 |
Male | 38 (58.5%) |
Female | 27 (42.5%) |
Positive family history | 21 (32.3%) |
Main clinical presentations n (%) | |
Recurrent Fever | 65 (100%) |
Recurrent oral lesions | 41 (63%) |
Recurrent abdominal pain | 20 (31%) |
Recurrent musculoskeletal pain | 4 (6%) |
Laboratory data | |
SAA level Mean ± SD (mg/L) | 162.5 ± 85.78 |
CRP (mg/dL) | 33 ± 15 |
Genetic data (Type of mutations) n (%) | |
Homozygous | 6 (10.7%) |
Heterozygous | 44 (78.6%) |
Compound Heterozygous | 6 (10.7%) |
Genetic data (Common mutations) n (%) 64 mutations in 56 patients | |
E148Q | 24 (37.5%) |
M694I | 18 (32.1%) |
V726A | 13 (20.3%) |
P369S | 5 (7.8%) |
M680I(G/A) | 3 (4.7%) |
R761H | 1 (1.6%) |
Mutation Type | SAA Mean ± SD | MEFVMutation | SAA Mean ± SD |
---|---|---|---|
Homozygous | 193.1 ± 20.61899 | E148Q | 170.9 ± 79.9 |
Heterozygous | 181.8 ± 74.1403 | M680I | 205.0 ± 8.2 |
Combined Heterozygous | 194.7 ± 16.01879 | M694I | 211.8 ± 46.1 |
p-value | 0.849 | V726A | 178.6 ± 20.1 |
p-value | 0.003 |
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Omran, A.; Abdelrahman, A.; Mohamed, Y.G.; Abdalla, M.O.; Abdel-Hamid, E.R.; Elfiky, S. Recurrent Fever with Oral Lesions in Egyptian Children: A Familial Mediterranean Fever Diagnosis Not to Be Missed. Children 2022, 9, 1654. https://doi.org/10.3390/children9111654
Omran A, Abdelrahman A, Mohamed YG, Abdalla MO, Abdel-Hamid ER, Elfiky S. Recurrent Fever with Oral Lesions in Egyptian Children: A Familial Mediterranean Fever Diagnosis Not to Be Missed. Children. 2022; 9(11):1654. https://doi.org/10.3390/children9111654
Chicago/Turabian StyleOmran, Ahmed, Ahmed Abdelrahman, Yasmine Gabr Mohamed, Mohamed Osama Abdalla, Eman R. Abdel-Hamid, and Samar Elfiky. 2022. "Recurrent Fever with Oral Lesions in Egyptian Children: A Familial Mediterranean Fever Diagnosis Not to Be Missed" Children 9, no. 11: 1654. https://doi.org/10.3390/children9111654