Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Informed Consent Statement
Conflicts of Interest
References
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Anatomic Region | Description |
---|---|
Different body compartments | Ipsilateral tumor extension within two body compartments (neck and chest or pelvis and abdomen |
Cervical region | Tumor encasing internal jugular vein, the carotid artery, or the vertebral artery Extension of tumor to skull base Compression of the trachea |
Thoracocervical Junction | Tumor encasing the brachial plexus roots Tumor encasing carotid artery, subclavian vessels, vertebral artery Compression of the trachea |
Thorax | Tumor encasing the aorta or important branches Tumor compressing the trachea/bronchi Lower mediastinal tumor with costovertebral junction infiltration (T9 and T12) |
Thoracoabdominal junction | Tumor encasing the vena cava or the aorta |
Pelvis or Abdomen | Tumor infiltrating the hepatoduodenal ligament or the porta hepatis Tumor encasing branches of the superior mesenteric artery Tumor encasing the origin of celiac axis or of the superior mesenteric artery Invasion of one or both renal pedicles Tumor encasing the vena cava or the aorta Tumor encasing the iliac vessels Pelvic tumor crossing the sciatic notch |
Infiltration of adjacent structures | Diaphragm, pericardium, liver, kidney, mesentery, and the duodenopancreatic block |
Intraspinal tumor extension | Invasion of more than 1/3 of the spinal canal, non-visible perimedullary leptomeningeal spaces or abnormal signal intensity of the spinal cord |
Characteristic | No. |
---|---|
Sex | N = 31 |
Male | 20 |
Female | 11 |
Primary tumor site | |
Neck | 0 |
Chest | 1 |
Abdomen | 7 |
Adrenal | 23 |
Abnormal NSE at diagnosis | 31 |
MYCN status | |
Non-amplified | 14 |
Amplified | 11 |
Not specified | 6 |
INSS stage | |
½ | 7 |
¾ | 24 |
INRGSS stage | |
L1 | 6 |
L2 | 6 |
M | 9 |
MS | 10 |
IDRF | |
Positive | 16 |
Negative | 13 |
Characteristic | No. (n = 31) |
---|---|
Pulmonary metastasis | 1 |
Hepatic metastasis | 12 |
Bone metastasis | 7 |
Bone marrow | 5 |
Skin/soft tissue metastasis | 4 |
Ganglia metastasis | 15 |
Renal metastasis | 2 |
Surgical Treatment | N = 31 |
---|---|
Upfront resection | 9 |
After neoadjuvant treatment | 14 |
No excision | 11 |
Biopsy | 10 |
Complete excision | 12 |
Incomplete excision | 8 |
Upfront chemotherapy | 17 |
Type of intervention | |
MIS | 5 |
Open | 17 |
Adjacent organ resection | 7 |
Reintervention | 8 |
Autologous stem cell transplantation | 7 |
Retinoid therapy | 8 |
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Laura, B.; Radu, B.; Patricia, C.; Andreea, M. Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma. Children 2022, 9, 1707. https://doi.org/10.3390/children9111707
Laura B, Radu B, Patricia C, Andreea M. Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma. Children. 2022; 9(11):1707. https://doi.org/10.3390/children9111707
Chicago/Turabian StyleLaura, Balanescu, Balanescu Radu, Cimpeanu Patricia, and Moga Andreea. 2022. "Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma" Children 9, no. 11: 1707. https://doi.org/10.3390/children9111707