Probiotics in Children with Asthma
Abstract
:1. Introduction
2. The Rationale for Probiotics in Pediatric Asthma
3. Systematic Reviews and Meta-Analyses of Probiotics in Asthma and Allergic Diseases
4. Probiotic Supplementation in Children with Asthma or Wheezing: The Most Relevant Studies
5. The PROPAM Study
5.1. Bifidobacterium Breve B632: The Evidence
5.2. Ligilactobacillus Salivarius LS01: The Evidence
5.3. Combined Bifidobacterium Breve B632 and Ligilactobacillus Salivarius LS01: The Evidence
6. Findings from the PROPAM Study
7. The Relevance of PROPAM Study in Asthma Management
8. Discussion
9. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Global Initiative for Asthma. GINA Guidelines. Global Strategy for Asthma Management and Prevention. 2022. Available online: Htpp://www.ginasthma.org/ (accessed on 4 June 2022).
- Tosca, M.A.; Schiavetti, I.; Duse, M.; Marseglia, G.; Ciprandi, G.; Licari, A.; Leone, M.; Di Cicco, M.E.; Bozzetto, S.; De Vittori, V.; et al. A Survey on the Management of Children with Asthma in Primary Care Setting in Italy. Pediatr. Allergy Immunol. Pulmonol. 2021, 34, 39–42. [Google Scholar] [CrossRef] [PubMed]
- Gaillard, E.A.; Kuehni, C.E.; Turner, S.; Goutaki, M.; Holden, K.A.; de Jong, C.C.; Lex, C.; Lo, D.K.; Lucas, J.S.; Midulla, F.; et al. European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years. Eur. Respir. J. 2021, 58, 2004173. [Google Scholar] [CrossRef] [PubMed]
- Akar-Ghibril, N.; Casale, T.; Custovic, A.; Phipatanakul, W. Allergic Endotypes and Phenotypes of Asthma. J. Allergy Clin. Immunol. Pr. 2020, 8, 429–440. [Google Scholar] [CrossRef] [PubMed]
- Martin, J.; Townshend, J.; Brodlie, M. Diagnosis and management of asthma in children. BMJ Paediatr. Open 2022, 6, e001277. [Google Scholar] [CrossRef]
- Patel, S.J.; Teach, S.J. Asthma. Ped. Rev. 2019, 40, 549–567. [Google Scholar] [CrossRef]
- Tenero, L.; Tezza, G.; Cattazzo, E.; Piacentini, G. Wheezing in preschool children. Early Hum. Develop. 2013, 89, S13–S17. [Google Scholar] [CrossRef]
- Muglia, C.; Oppenheimer, J. Wheezing in Infancy: An Overview of Recent Literature. Curr. Allergy Asthma Rep. 2017, 17, 6. [Google Scholar] [CrossRef]
- Chatziparasidis, G.; Bush, A. Enigma variations: The multi-faceted problems of the pre-school wheeze. Pediatr. Pulmonol. 2022, in press. [Google Scholar] [CrossRef]
- Chou, E.Y.; Pelz, B.J.; Chiu, A.M.; Soung, P.J. All that Wheezes is not Asthma or Bronchiolitis. Crit. Care Clin. 2022, 38, 213–229. [Google Scholar] [CrossRef]
- Ducharme, F.M.; Tse, S.M.; Chauhan, B. Diagnosis, management, and prognosis of preschool wheeze. Lancet 2014, 383, 1593–1604. [Google Scholar] [CrossRef]
- Lecerf, K.; Prince, B.T. Paediatric asthma—All that wheezes is not necessarily asthma—Current diagnostic and management strategies. Curr. Opin. Pulm. Med. 2022, 28, 258–265. [Google Scholar] [CrossRef] [PubMed]
- Ramsahai, J.M.; Pathinayake, P.; Malik, B.; Bartlett, N.W.; Wark, P.A.B. Respiratory Viruses and Asthma. Semin. Respir. Crit. Care Med. 2018, 38, 45–55. [Google Scholar] [CrossRef] [PubMed]
- Maciag, M.C.; Phipatanakul, W. Prevention of Asthma: Targets for Intervention. Chest 2020, 158, 913–922. [Google Scholar] [CrossRef] [PubMed]
- Platts-Mills, T.A. The allergy epidemics: 1870–2010. J. Allergy Clin. Immunol. 2015, 136, 3–13. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Strachan, D.P. Hay fever, hygiene, and household size. BMJ 1989, 299, 1259–1260. [Google Scholar] [CrossRef] [Green Version]
- Haahtela, T. A biodiversity hypothesis. Allergy 2019, 74, 1445–1456. [Google Scholar] [CrossRef] [Green Version]
- Convention on Biological Diversity 1992. Available online: www.biodiv.org/convention (accessed on 4 June 2022).
- Hufnagl, K.; Pali-Schöll, I.; Roth-Walter, F.; Jensen-Jarolim, E. Dysbiosis of the gut and lung microbiome has a role in asthma. Semin. Immunopathol. 2020, 42, 75–93. [Google Scholar] [CrossRef] [Green Version]
- Cukrowska, B.; Bierła, J.B.; Zakrzewska, M.; Klukowski, M.; Maciorkowska, E. The Relationship between the Infant Gut Microbiota and Allergy. The Role of Bifidobacterium breve and Prebiotic Oligosaccharides in the Activation of Anti-Allergic Mechanisms in Early Life. Nutrients 2020, 12, 946. [Google Scholar] [CrossRef] [Green Version]
- Kang, Y.; Cai, Y.; Zhang, H. Gut microbiota and allergy/asthma: From pathogenesis to new therapeutic strategies. Allergol. Immunopathol. 2017, 45, 305–309. [Google Scholar] [CrossRef]
- Dang, A.T.; Marsland, B.J. Microbes, metabolites, and the gut-lung axis. Mucosal Immunol. 2019, 12, 843–850. [Google Scholar] [CrossRef] [Green Version]
- FAO/WHO. Expert Consultation Health and Nutrition Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria. Available online: http://isappscience.org/wp-content/uploads/2015/12/FAO-WHO-2001-ProbioticsReport.pdf (accessed on 4 June 2022).
- Wang, H.; Anvari, S.; Anagnostou, K. The Role of Probiotics in Preventing Allergic Disease. Children 2019, 6, 24. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Balta, I.; Butucel, E.; Mohylyuk, V.; Criste, A.; Dezmirean, D.S.; Stef, L.; Pet, I.; Corcionivoschi, N. Novel Insights into the Role of Probiotics in Respiratory Infections, Allergies, Cancer, and Neurological Abnormalities. Diseases 2021, 9, 60. [Google Scholar] [CrossRef] [PubMed]
- Maldonado Galdeano, C.; Cazorla, S.I.; Lemme Dumit, J.M.; Vélez, E.; Perdigón, G. Beneficial Effects of Probiotic Consumption on the Immune System. Ann. Nutr. Metab. 2019, 74, 115–124. [Google Scholar] [CrossRef] [PubMed]
- AL Nabhani, Z.; Eberl, G. Imprinting of the immune system by the microbiota early in life. Mucosal Immunol. 2020, 13, 183–189. [Google Scholar] [CrossRef] [Green Version]
- Huang, J.; Zhang, J.; Wang, X.; Jin, Z.; Zhang, P.; Su, H.; Sun, X. Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota. Front. Nutr. 2022, 9, 247. [Google Scholar] [CrossRef]
- Cristofori, F.; Dargenio, V.N.; Dargenio, C.; Miniello, V.L.; Barone, M.; Francavilla, R. Anti-inflammatory and immunomodu-latory effects of probiotics in gut inflammation: A door to the body. Front. Immunol. 2021, 12, 578386. [Google Scholar] [CrossRef]
- Lin, C.; Lin, Y.; Zhang, H.; Wang, G.; Zhao, J.; Zhang, H.; Chen, W. Intestinal ‘Infant-Type’ Bifidobacteria Mediate Immune System Development in the First 1000 Days of Life. Nutrients 2022, 14, 1498. [Google Scholar] [CrossRef]
- Das, R.R.; Naik, S.; Singh, M. Probiotics as Additives on Therapy in Allergic Airway Diseases: A Systematic Review of Benefits and Risks. BioMed Res. Int. 2013, 2013, 231979. [Google Scholar] [CrossRef]
- Lin, J.; Zhang, Y.; He, C.; Dai, J. Probiotics supplementation in children with asthma: A systematic review and meta-analysis. J. Paediatr. Child Health 2018, 54, 953–961. [Google Scholar] [CrossRef]
- Du, X.; Wang, L.; Wu, S.; Yuan, L.; Tang, S.; Xiang, Y.; Qu, X.; Liu, H.; Qin, X.; Liu, C. Efficacy of probiotic supplementary therapy for asthma, allergic rhinitis, and wheeze: A meta-analysis of randomized controlled trials. Allergy Asthma Proc. 2019, 40, 250–260. [Google Scholar] [CrossRef]
- Wei, X.; Jiang, P.; Liu, J.; Sun, R.; Zhu, L. Association between probiotic supplementation and asthma incidence in infants: A meta-analysis of randomized controlled trials. J. Asthma 2019, 57, 167–178. [Google Scholar] [CrossRef] [PubMed]
- Meirlaen, L.; Levy, E.I.; Vandenplas, Y. Prevention and management with pro-, pre- and synbiotics in children with asthma and allergic rhinitis: A narrative review. Nutrients 2021, 13, 934. [Google Scholar] [CrossRef] [PubMed]
- Chen, N.; Liu, F.; Gao, Q.; Wang, R.; Zhang, L.; Li, Y. A meta-analysis of probiotics for the treatment of allergic diseasein children and adolescents. Am. J. Rhinol. Allergy 2022, in press. [Google Scholar] [CrossRef] [PubMed]
- Giovannini, M.; Agostoni, C.; Riva, E.; Salvini, F.; Ruscitto, A.; Zuccotti, G.V.; Radaelli, G. A Randomized Prospective Double Blind Controlled Trial on Effects of Long-Term Consumption of Fermented Milk Containing Lactobacillus casei in Pre-School Children with Allergic Asthma and/or Rhinitis. Pediatr. Res. 2007, 62, 215–220. [Google Scholar] [CrossRef]
- Rose, M.A.; Stieglitz, F.; Köksal, A.; Schubert, R.; Schulze, J.; Zielen, S. Efficacy of probiotic Lactobacillus GG on allergic sensitization and asthma in infants at risk. Clin. Exp. Allergy 2010, 40, 1398–1405. [Google Scholar] [CrossRef]
- Chen, Y.-S.; Lin, Y.-L.; Jan, R.-L.; Chen, H.-H.; Wang, J.-Y. Randomized placebo-controlled trial of lactobacillus on asthmatic children with allergic rhinitis. Pediatr. Pulmonol. 2010, 45, 1111–1120. [Google Scholar] [CrossRef]
- Del Giudice, M.M.; Maiello, N.; Decimo, F.; Fusco, N.; Agostino, B.D.; Sullo, N.; Capasso, M.; Salpietro, V.; Gitto, E.; Ciprandi, G.; et al. Airways allergic inflammation and L. reuterii treatment in asthmatic children. J. Biol. Regul. Homeost. Agents 2012, 26, S35–S40. [Google Scholar]
- Niers, L.; Martin, R.; Rijkers, G.; Sengers, F.; Timmerman, H.; Van Uden, N.; Smidt, H.; Kimpen, J.; Hoekstra, M. The effects of selected probiotic strains on the development of eczema (the PandA study). Allergy 2009, 64, 1349–1358. [Google Scholar] [CrossRef]
- Gorissen, D.M.W.; Rutten, N.B.M.M.; Oostermeijer, C.M.J.; Niers, L.E.M.; Hoekstra, M.O.; Rijkers, G.T.; Van Der Ent, C.K. Preventive effects of selected probiotic strains on the development of asthma and allergic rhinitis in childhood. The Panda study. Clin. Exp. Allergy 2014, 44, 1431–1433. [Google Scholar] [CrossRef]
- Kuitunen, M.; Kukkonen, K.; Juntunen-Backman, K.; Korpela, R.; Poussa, T.; Tuure, T.; Haahtela, T.; Savilahti, E. Probiotics prevent IgE-associated allergy until age 5 years in cesarean-delivered children but not in the total cohort. J. Allergy Clin. Immunol. 2009, 123, 335–341. [Google Scholar] [CrossRef]
- Abrahamsson, T.R.; Jakobsson, T.; Björkstén, B.; Oldaeus, G.; Jenmalm, M.C. No effect of probiotics on respiratory allergies: A seven-year follow-up of a randomized controlled trial in infancy. Pediatr. Allergy Immunol. 2013, 24, 556–561. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Wickens, K.; Stanley, T.V.; Mitchell, E.A.; Barthow, C.; Fitzharris, P.; Purdie, G.; Siebers, R.; Black, P.N.; Crane, J. Early sup-plementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: Does it also reduce atopic sensiti-zation? Clin. Exp. Allergy 2013, 43, 1048–1057. [Google Scholar] [CrossRef] [PubMed]
- West, C.E.; Hammarström, M.-L.; Hernell, O. Probiotics in primary prevention of allergic disease—Follow-up at 8-9 years of age. Allergy 2013, 68, 1015–1020. [Google Scholar] [CrossRef]
- Del Giudice, M.M.; Indolfi, C.; Capasso, M.; Maiello, N.; Decimo, F.; Ciprandi, G. Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma. Ital. J. Pediatr. 2017, 43, 25. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ahanchian, H.; Jafari, S.A.; Ansari, E.; Ganji, T.; Kiani, M.A.; Khalesi, M.; Momen, T.; Kianifar, H. A multi-strain Synbiotic may reduce viral respiratory infections in asthmatic children: A randomized controlled trial. Electron. Physician 2016, 8, 2833–2839. [Google Scholar] [CrossRef] [Green Version]
- Hassanzad, M.; Mostashari, K.M.; Ghaffaripour, H.; Emami, H.; Limouei, S.R.; Velayati, A.A. Synbiotics and treatment of asthma: A double-blinded, randomized, placebo-controlled clinical trial. Galen Med. J. 2019, 8, e1350. [Google Scholar] [CrossRef]
- Drago, L.; Cioffi, L.; Giuliano, M.; Pane, M.; Amoruso, A.; Schiavetti, I.; Reid, G.; Ciprandi, G. The PRObiotics in Pediatric Asthma Management (PROPAM) study in the primary care setting: A randomized, controlled, double-blind trial with Ligilactobacillus salivarius LS01 (DSM 22775) and Bifidobacterium breve B632 (DSM 24706). J. Immunol. Res. 2022, 2022, 3837418. [Google Scholar] [CrossRef]
- Oelschlaeger, T.A. Mechanisms of probiotic actions—A review. Int. J. Med. Microbiol. 2010, 300, 57–62. [Google Scholar] [CrossRef]
- Rossi, M.; Amaretti, A.; Leonardi, A.; Raimondi, S.; Simone, M.; Quartieri, A. Potential Impact of Probiotic Consumption on the Bioactivity of Dietary Phytochemicals. J. Agric. Food Chem. 2013, 61, 9551–9558. [Google Scholar] [CrossRef]
- Aloisio, I.; Santini, C.; Biavati, B.; Dinelli, G.; Cencič, A.; Chingwaru, W.; Mogna, L.; Di Gioia, D. Characterization of Bifidobacterium spp. strains for the treatment of enteric disorders in newborns. Appl. Microbiol. Biotechnol. 2012, 96, 1561–1576. [Google Scholar] [CrossRef]
- Mogna, L.; Del Piano, M.; Mogna, G. Capability of the Two Microorganisms Bifidobacterium breve B632 and Bifidobacterium breve BR03 to Colonize the Intestinal Microbiota of Children. J. Clin. Gastroenterol. 2014, 48, S37–S39. [Google Scholar] [CrossRef] [PubMed]
- Simone, M.; Gozzoli, C.; Quartieri, A.; Mazzola, G.; Di Gioia, D.; Amaretti, A. The probiotic Bifidobacterium breve B632 inhibited the growth of Enterobacteriaceae within colicky infant microbiota cultures. BioMed. Res. Int. 2014, 2014, 301053. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Giglione, E.; Prodam, F.; Bellone, S.; Monticone, S.; Beux, S.; Marolda, A.; Pagani, A.; Di Gioia, D.; Del Piano, M.; Mogna, G.; et al. The Association of Bifidobacterium breve BR03 and B632 is Effective to Prevent Colics in Bottle-fed Infants. J. Clin. Gastroenterol. 2016, 50, S164–S167. [Google Scholar] [CrossRef] [PubMed]
- Solito, A.; Bozzi Cionci, N.; Calgaro, M.; Caputo, M.; Vannini, L.; Hasballa, I.; Aechero, F.; Giglione, E.; Ricotti, R.; Walker, G.E.; et al. Supplentation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial. Clin. Nutr. 2021, 40, 4585–4594. [Google Scholar] [CrossRef] [PubMed]
- Taylor, A.L.; Dunstan, J.A.; Prescott, S.L. Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial. J. Allergy Clin. Immunol. 2007, 119, 184–191. [Google Scholar] [CrossRef]
- Drago, L.; Iemoli, E.; Rodighiero, V.; Nicola, L.; De Vecchi, E.; Piconi, S. Effects of Lactobacillus Salivarius LS01 (DSM 22775) Treatment on Adult Atopic Dermatitis: A Randomized Placebo-Controlled Study. Int. J. Immunopathol. Pharmacol. 2011, 24, 1037–1048. [Google Scholar] [CrossRef]
- Drago, L.; De Vecchi, E.; Toscano, M.; Vassena, C.; Altomare, G.; Pigatto, P. Treatment of atopic dermatitis eczema with a high concentration of Lactobacillus salivarius LS01 associated with an innovative gelling complex a pilot study on adults. J. Clin. Gastroenterol. 2014, 48, S47–S51. [Google Scholar] [CrossRef]
- Dec, M.; Stępień-Pyśniak, D.; Puchalski, A.; Hauschild, T.; Pietras-Ożga, D.; Ignaciuk, S.; Urban-Chmiel, R. Biodiversity of Ligilactobacillus salivarius Strains from Poultry and Domestic Pigeons. Animals 2021, 11, 972. [Google Scholar] [CrossRef]
- Magistrelli, L.; Amoruso, A.; Mogna, L.; Graziano, T.; Cantello, R.; Pane, M.; Comi, C. Probiotics May Have Beneficial Effects in Parkinson’s Disease: In vitro Evidence. Front. Immunol. 2019, 10, 969. [Google Scholar] [CrossRef] [Green Version]
- Iemoli, E.; Trabattoni, D.; Parisotto, S.; Borgonovo, L.; Toscano, M.; Rizzardini, G.; Clerici, M.; Ricci, E.; Fusi, A.; De Vecchi, E.; et al. Probiotics Reduce Gut Microbial Translocation and Improve Adult Atopic Dermatitis. J. Clin. Gastroenterol. 2012, 46, S33–S40. [Google Scholar] [CrossRef]
- Nettis, E.; Di Leo, E.; Pastore, A.; Distaso, M.; Zaza, I.; Vacca, M.; Macchia, L.; Vacca, A. Probiotics and refractory chronic spontaneous urticaria. Eur. Ann. Allergy Clin. Immunol. 2016, 48, 182–187. [Google Scholar] [PubMed]
- Fortuna, M.C.; Garelli, V.; Pranteda, G.; Romaniello, F.; Cardone, M.; Carlesimo, M.; Rossi, A. A case of Scalp Rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options. Dermatol. Ther. 2016, 29, 249–251. [Google Scholar] [CrossRef] [PubMed]
- Drago, L.; De Vecchi, E.; Gabrieli, A.; De Grandi, R.; Toscano, M. Immunomodulatory effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, alone and in combination, on peripheral blood mononuclear cells of allergic asthmatics. Allergy Asthma Immunol. Res. 2015, 7, 409–413. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Indinnimeo, L.; Chiappini, E.; Miraglia del Giudice, M.; Bernardini, R. Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics. Ital. J. Pediatr. 2018, 44, 46. [Google Scholar] [CrossRef]
- Hoch, H.E.; Houin, P.R.; Stillwell, P.C. Asthma in Children: A Brief Review for Primary Care Providers. Pediatr. Ann. 2019, 48, e103–e109. [Google Scholar] [CrossRef]
- Fu, L.-S.; Tsai, M.-C. Asthma Exacerbation in Children: A Practical Review. Pediatr. Neonatol. 2014, 55, 83–91. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Acute Asthma Exacerbation in Children. BMJ Best Practice. Available online: https://bestpractice.bmj.com/topics/en-gb/1098 (accessed on 4 June 2022).
- Fuhlbrigge, A.; Peden, D.; Apter, A.J.; Boushey, H.A.; Camargo, H.A., Jr.; Gern, J.; Heymann, P.W.; Martinez, F.D.; Mauger, D.; Teaugue, W.G.; et al. Asthma outcomes: Exacerbations. J. Allergy Clin. Immunol. 2012, 129, S34–S48. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Abul, M.H.; Phipatanakul, W. Severe asthma in children: Evaluation and management. Allergol. Int. 2019, 68, 150–157. [Google Scholar] [CrossRef]
- Jartti, T.; Gern, J.E. Role of viral infections in the development and exacerbation of asthma in children. J. Allergy Clin. Immunol. 2017, 140, 895–906. [Google Scholar] [CrossRef] [Green Version]
- Bousquet, J.; Farrell, J.; Crooks, G.; Hellings, P.; Bel, E.H.; Bewick, M.; Chavannes, N.H.; de Sousa, J.C.; Cruz, A.A.; Haahtela, T.; et al. Scaling up strategies ofthe chronic respiratory disease programme ofthe European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clin. Transl. Allergy. 2016, 6, 29. [Google Scholar] [CrossRef] [Green Version]
- Bousquet, J.J.; the ARIA Study Group; Schünemann, H.J.; Togias, A.; Erhola, M.; Hellings, P.W.; Zuberbier, T.; Agache, I.; Ansotegui, I.J.; Anto, J.M.; et al. Next-generation ARIA care pathways for rhinitis and asthma: A model for multimorbid chronic diseases. Clin. Transl. Allergy 2019, 9, 44. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Tsolakis, N.; Jacinto, T.; Malinovschi, A.; Borres, M.; Janson, C.; Alving, K. Relationship between longitudinal changes in type-2 inflammation, immunoglobulin E sensitization, and clinical outcomes in young asthmatics. Clin. Transl. Allergy. 2021, 11, e12066. [Google Scholar] [CrossRef] [PubMed]
- Indinnimeo, L.; Porta, D.; Forastiere, F.; De Vittori, V.; De Castro, G.; Zicari, A.M.; Tancredi, G.; Melengu, T.; Duse, M. Prevalence and risk factors for atopic disease in a population of preschool children in Rome: Challenges to early intervention. Int. J. Immunopathol. Pharmacol. 2016, 29, 308–319. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Jakubczyk, D.; Górska, S. Impact of Probiotic Bacteria on Respiratory Allergy Disorders. Front. Microbiol. 2021, 12, 688137. [Google Scholar] [CrossRef]
- Wawryk-Gawda, E.; Markut-Miotła, E.; Emeryk, A. Postnatal probiotics administration does not prevent asthma in children, but using prebiotics or synbiotics may be the effective potential strategies to decrease the frequency of asthma in high-risk children—A meta-analysis of clinical trials. Allergol. Immunopathol. 2021, 49, 4–14. [Google Scholar] [CrossRef]
- Guillot, L.; Nathan, N.; Tabary, O.; Thouvenin, G.; Le Rouzic, P.; Corvol, H.; Amselem, S.; Clement, A. Alveolar epithelial cells: Master regulators of lung homeostasis. Int. J. Biochem. Cell Biol. 2013, 45, 2568–2573. [Google Scholar] [CrossRef]
- Peterson, L.W.; Artis, D. Intestinal epithelial cells: Regulators of barrier function and immune homeostasis. Nat. Rev. Immunol. 2014, 14, 141–153. [Google Scholar] [CrossRef]
- Miyauchi, E.; O′Callaghan, J.; Buttó, L.F.; Hurley, G.; Melgar, S.; Tanabe, S.; Shanahan, F.; Nally, K.; O′Toole, P.W. Mechanism of protection of transepithelial barrier function by Lactobacillus salivarius: Strain dependence and attenuation by bacteriocin production. Am. J. Physiol. Gastrointest. Liver Physiol. 2012, 303, G1029–G1041. [Google Scholar] [CrossRef] [Green Version]
- Vissers, Y.M.; Snel, J.; Zuurendonk, P.F.; Kleerebezem, M.; Wichers, H.; Savelkoul, H.F. Lactobacillus strains differentially modulate cytokine production by hPBMC from pollen-allergic patients. FEMS Immunol. Med. Microbiol. 2010, 61, 28–40. [Google Scholar] [CrossRef]
- Resta-Lenert, S.; Barrett, K.E. Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Gastroenterology 2006, 130, 731–746. [Google Scholar] [CrossRef]
- Abdel-Gadir, A.; Stephen-Victor, E.; Gerber, G.K. Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy. Nat. Med. 2019, 25, 1164–1174. [Google Scholar] [CrossRef] [PubMed]
- Ciprandi, G.; Cioffi, L.; Giuliano, M.; Pane, M.; Drago, L. The PRObiotics in Pediatric Asthma Management (PROPAM) study: A post hoc analysis in preschoolers. Pediatr. Pulmonol. 2022, 57, 1355–1357. [Google Scholar] [CrossRef] [PubMed]
- Drago, L.; Cioffi, L.; Giuliano, M.; Pane, M.; Ciprandi, G.; the PROPAM Study Group. A post hoc analysis on the effects of a probiotic mixture on asthma exacerbation frequency in schoolchildren. ERJ Open Res. 2022, 8. [Google Scholar] [CrossRef] [PubMed]
- Garcia-Garcia, M.L.; Rey, C.C.; Rabes, T.D.R. Pediatric Asthma and Viral Infection. Arch. Bronconeumol. 2016, 52, 269–273. [Google Scholar] [CrossRef] [PubMed]
- Muehling, L.M.; Heymann, P.W.; Carper, H.; Murphy, D.D.; Rajadhyaksha, E.; Kennedy, J.; Early, S.V.; Soto-Quiros, M.; Avila, L.; Workman, L.; et al. Cluster analysis of nasal cytokines during rhinovirus infection identifies different immunophenotypes in both children and adults with allergic asthma. Clin. Exp. Allergy 2022. [Google Scholar] [CrossRef]
- Panchal, N.; Ghosh, S.; Booth, C. T cell gene therapy to treat immunodeficiency. Br. J. Haematol. 2021, 192, 433–443. [Google Scholar] [CrossRef]
- Ciprandi, G.; Schiavetti, I.; Cioffi, L.; Pane, M.; Drago, L. The Probiotics in Pediatric Asthma Management (PROPAM) study: A Post Hoc analysis in allergic children. Ann. Allergy Asthma Immunol. 2022, in press. [Google Scholar] [CrossRef]
- Ciprandi, G.; Cioffi, L.; Schiavetti, I.; del Giudice, M.M.; Tosca, M.A. Factors associated with wheezing recurrence in clinical practice. J. Asthma 2022, 1–2. [Google Scholar] [CrossRef]
- Ciprandi, G.; Giuliano, M.; Schiavetti, I.; del Giudice, M.M.; Tosca, M. Factors associated with asthma exacerbations in schoolchildren: An experience in clinical practice. Eur. Ann. Allergy Clin. Immunol. 2022. [Google Scholar] [CrossRef]
- Ciprandi, G. Pediatric Asthma: A Daily Challenge. Children 2022, 18, 576. [Google Scholar] [CrossRef]
- von Mutius, E. The “Hygiene Hypothesis” and the Lessons Learnt from Farm Studies. Front. Immunol. 2021, 12, 63552. [Google Scholar] [CrossRef] [PubMed]
- Fiuza, B.S.D.; Fonseca, H.F.; Meirelles, P.M.; Marques, C.R.; da Silva, T.M.; Figueiredo, C.A. Understanding Asthma and Allergies by the Lens of Biodiversity and Epigenetic Changes. Front. Immunol. 2021, 12, 623737. [Google Scholar] [CrossRef] [PubMed]
- Garn, H.; Potaczek, D.P.; Pfefferle, P.I. The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate. Front. Immunol. 2021, 12, 637087. [Google Scholar] [CrossRef] [PubMed]
- Pfefferle, P.I.; Keber, C.U.; Cohen, R.M.; Garn, H. The Hygiene Hypothesis—Learning from but Not Living in the Past. Front. Immunol. 2021, 12, 635935. [Google Scholar] [CrossRef]
- Guryanova, S.V.; Gigani, O.B.; Gudima, G.O.; Kataeva, A.M.; Kolesnikova, N.V. Dual Effect of Low-Molecular-Weight Bioregulators of Bacterial Origin in Experimental Model of Asthma. Life 2022, 12, 192. [Google Scholar] [CrossRef]
- Colquitt, A.S.; Miles, E.A.; Calder, P.C. Do Probiotics in Pregnancy Reduce Allergies and Asthma in Infancy and Childhood? A Systematic Review. Nutrients 2022, 14, 1852. [Google Scholar] [CrossRef]
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Ciprandi, G.; Tosca, M.A. Probiotics in Children with Asthma. Children 2022, 9, 978. https://doi.org/10.3390/children9070978
Ciprandi G, Tosca MA. Probiotics in Children with Asthma. Children. 2022; 9(7):978. https://doi.org/10.3390/children9070978
Chicago/Turabian StyleCiprandi, Giorgio, and Maria Angela Tosca. 2022. "Probiotics in Children with Asthma" Children 9, no. 7: 978. https://doi.org/10.3390/children9070978