Disruption of the Corticospinal Tract in Patients with Acute Lymphoblastic Leukemia: A Case Series
Abstract
:1. Introduction
2. Case Presentation
2.1. Case 1
2.2. Case 2
2.3. Case 3
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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P1 | P2 | P3 | C1 | C2 | C3 | |
---|---|---|---|---|---|---|
Age | 6 y 4 m | 6 y 2 m | 4 y 10 m | 6 y 3 m | 6 y 3 m | 4 y 11 m |
Sex | Male | Male | Female | Male | Male | Female |
Handedness | Right | Right | Right | Right | Right | Right |
Period from diagnosis of ALL to examination | 4 m | 7 m | 20 m | 4 m | 7 m | 19 m |
Purdue test | 12/8 | 6/8 | 8/5 | 11/10 | 12/10 | 8/7 |
P1 | P2 | P3 | C1 | C2 | C3 | |
---|---|---|---|---|---|---|
WBC at diagnosis (/µL) | 2500 | 6860 | 2130 | 18,110 | 14,250 | 91,820 |
immunophenotype | SR | SR | SR | B | B + myeloid | SR |
CNS status | negative | negative | negative | negative | negative | negative |
Protocol | Modified BFM | Modified BFM | Modified BFM | Modified BFM | Modified BFM | Modified BFM |
Risk group | SR | SR | SR | SR | SR | HR |
Cytogenetics | Hyperdiploidy | Hyperdiploidy | Hyperdiploidy | Hyperdiploidy | TEL/AML1 | MLL rearrangement |
P1 | P2 | P3 | C1 | C2 | C3 | |
---|---|---|---|---|---|---|
FA affected * | 0.412 | 0.225 | 0.415 | 0.587 | 0.562 | 0.515 |
Unaffected # | 0.481 | 0.356 | 0.472 | 0.601 | 0.570 | 0.491 |
ADC affected * | 0.96 | 1.144 | 0.95 | 0.84 | 0.769 | 0.921 |
unaffected # | 0.901 | 0.927 | 0.94 | 0.867 | 0.801 | 0.894 |
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Lee, J.M.; Kim, J.B.; Byun, D.H.; Son, S.M. Disruption of the Corticospinal Tract in Patients with Acute Lymphoblastic Leukemia: A Case Series. Children 2022, 9, 1223. https://doi.org/10.3390/children9081223
Lee JM, Kim JB, Byun DH, Son SM. Disruption of the Corticospinal Tract in Patients with Acute Lymphoblastic Leukemia: A Case Series. Children. 2022; 9(8):1223. https://doi.org/10.3390/children9081223
Chicago/Turabian StyleLee, Jae Min, Jong Bum Kim, Dong Hyun Byun, and Su Min Son. 2022. "Disruption of the Corticospinal Tract in Patients with Acute Lymphoblastic Leukemia: A Case Series" Children 9, no. 8: 1223. https://doi.org/10.3390/children9081223