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Review

Exhaled Breath Condensate for Proteomic Biomarker Discovery

by
Sean W. Harshman
1,*,
Claude C. Grigsby
2 and
Darrin K. Ott
3
1
UES Inc., Air Force Research Laboratory, 711th Human Performance Wing/RHXBC, Wright-Patterson AFB, OH 45433, USA
2
Air Force Research Laboratory, 711th Human Performance Wing/RHXBC, Wright-Patterson AFB, OH 45433, USA
3
Air Force Research Laboratory, 711th Human Performance Wing, U.S. Air Force School of Aerospace Medicine/OET, Wright-Patterson AFB, OH 45433, USA
*
Author to whom correspondence should be addressed.
Chromatography 2014, 1(3), 108-119; https://doi.org/10.3390/chromatography1030108
Submission received: 8 May 2014 / Revised: 20 June 2014 / Accepted: 24 June 2014 / Published: 2 July 2014
(This article belongs to the Special Issue Recent Advancements in Analysis of Biomolecules with Separation Technologies)
Versions Notes

Abstract

Exhaled breath condensate (EBC) has been established as a potential source of respiratory biomarkers. Compared to the numerous small molecules identified, the protein content of EBC has remained relatively unstudied due to the methodological and technical difficulties surrounding EBC analysis. In this review, we discuss the proteins identified in EBC, by mass spectrometry, focusing on the significance of those proteins identified. We will also review the limitations surrounding mass spectral EBC protein analysis emphasizing recommendations to enhance EBC protein identifications by mass spectrometry. Finally, we will provide insight into the future directions of the EBC proteomics field.
Keywords: exhaled breath condensate; proteomics; mass spectrometry exhaled breath condensate; proteomics; mass spectrometry

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MDPI and ACS Style

Harshman, S.W.; Grigsby, C.C.; Ott, D.K. Exhaled Breath Condensate for Proteomic Biomarker Discovery. Chromatography 2014, 1, 108-119. https://doi.org/10.3390/chromatography1030108

AMA Style

Harshman SW, Grigsby CC, Ott DK. Exhaled Breath Condensate for Proteomic Biomarker Discovery. Chromatography. 2014; 1(3):108-119. https://doi.org/10.3390/chromatography1030108

Chicago/Turabian Style

Harshman, Sean W., Claude C. Grigsby, and Darrin K. Ott. 2014. "Exhaled Breath Condensate for Proteomic Biomarker Discovery" Chromatography 1, no. 3: 108-119. https://doi.org/10.3390/chromatography1030108

APA Style

Harshman, S. W., Grigsby, C. C., & Ott, D. K. (2014). Exhaled Breath Condensate for Proteomic Biomarker Discovery. Chromatography, 1(3), 108-119. https://doi.org/10.3390/chromatography1030108

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