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Volume 9
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10.3390/separations9020040
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Article

Simultaneous Quantification of Vitamin A and Derivatives in Cosmetic Products by Liquid Chromatography with Ultraviolet Detection

by
Víctor Vállez-Gomis
,
Sonia Carchano-Olcina
,
Cristian Azorín
,
Juan L. Benedé
,
Alberto Chisvert
and
Amparo Salvador
*
GICAPC Research Group, Department of Analytical Chemistry, University of Valencia, Doctor Moliner St. 50, Burjassot, 46100 Valencia, Spain
*
Author to whom correspondence should be addressed.
Separations 2022, 9(2), 40; https://doi.org/10.3390/separations9020040
Submission received: 12 January 2022 / Revised: 25 January 2022 / Accepted: 29 January 2022 / Published: 1 February 2022
(This article belongs to the Section Analysis of Natural Products and Pharmaceuticals)
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Abstract

Vitamin A (retinol) and some of its derivatives are a group of fat-soluble compounds used in cosmetic products as bioactive ingredients. Therefore, it is necessary to perform the quality control of final product to ensure their efficacy and safety. A simple and rapid method to determine retinol, retinal, retinyl acetate, retinyl propionate and retinyl palmitate in cosmetics is presented here. The method is based on vortex and/or ultrasound-assisted leaching of the analytes in ethanol followed by liquid chromatography with ultraviolet detection. The analytical performance of the method was evaluated. It has shown high levels of linearity, at least up to 100 µg mL−1; high precision with RSD values below 14% and high sensitivity with low MLODs ranging between 0.3 × 10−4 and 5.9 × 10−4 % w/w, which are enough to monitor these compounds in cosmetic products. The proposed method was successfully applied to seven commercial cosmetic samples to detect and quantify the target analytes, showing the method is suitable for its employment for quality control in cosmetic industries. Cosmetic samples were spiked at two levels of concentration and recovery values around 100% were obtained, showing no significant matrix effects and, therefore, external calibration was adequate for this determination.
Keywords: cosmetic products; fat-soluble vitamins; liquid chromatography; retinoids; vitamin A cosmetic products; fat-soluble vitamins; liquid chromatography; retinoids; vitamin A

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MDPI and ACS Style

Vállez-Gomis, V.; Carchano-Olcina, S.; Azorín, C.; Benedé, J.L.; Chisvert, A.; Salvador, A. Simultaneous Quantification of Vitamin A and Derivatives in Cosmetic Products by Liquid Chromatography with Ultraviolet Detection. Separations 2022, 9, 40. https://doi.org/10.3390/separations9020040

AMA Style

Vállez-Gomis V, Carchano-Olcina S, Azorín C, Benedé JL, Chisvert A, Salvador A. Simultaneous Quantification of Vitamin A and Derivatives in Cosmetic Products by Liquid Chromatography with Ultraviolet Detection. Separations. 2022; 9(2):40. https://doi.org/10.3390/separations9020040

Chicago/Turabian Style

Vállez-Gomis, Víctor, Sonia Carchano-Olcina, Cristian Azorín, Juan L. Benedé, Alberto Chisvert, and Amparo Salvador. 2022. "Simultaneous Quantification of Vitamin A and Derivatives in Cosmetic Products by Liquid Chromatography with Ultraviolet Detection" Separations 9, no. 2: 40. https://doi.org/10.3390/separations9020040

APA Style

Vállez-Gomis, V., Carchano-Olcina, S., Azorín, C., Benedé, J. L., Chisvert, A., & Salvador, A. (2022). Simultaneous Quantification of Vitamin A and Derivatives in Cosmetic Products by Liquid Chromatography with Ultraviolet Detection. Separations, 9(2), 40. https://doi.org/10.3390/separations9020040

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