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Medicines, Volume 10, Issue 12 (December 2023) – 1 article

Cover Story (view full-size image): Malnutrition in cardiovascular disease is associated with poor prognosis, especially in patients with heart failure and acute coronary syndrome (ACS). High bleeding risk is also linked to coronary artery disease prognosis, including ACS. However, whether the extent of malnutrition and high bleeding risk have a cumulative impact on the long-term prognosis of patients with ACS who undergo percutaneous coronary intervention remains unclear. We analyzed 275 patients with ACS treated with percutaneous coronary intervention. The study shows that moderate or severe malnutrition has a significant impact on the long-term prognosis of patients with ACS who undergo percutaneous coronary intervention. View this paper
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11 pages, 1733 KiB  
Article
Association of Malnutrition and High Bleeding Risk with Long-Term Prognosis in Patients with Acute Coronary Syndrome following Percutaneous Coronary Intervention
by Hiromitsu Kataoka, Sayumi Suzuki, Yuichi Suzuki, Ryota Sato, Makoto Sano, Satoshi Mogi, Atsushi Sakamoto, Kenichiro Suwa, Yoshihisa Naruse, Hayato Ohtani, Masao Saotome, Mikihiro Shimizu, Keiichi Odagiri and Yuichiro Maekawa
Medicines 2023, 10(12), 62; https://doi.org/10.3390/medicines10120062 - 30 Nov 2023
Viewed by 2182
Abstract
Background: Malnutrition in cardiovascular disease is associated with poor prognosis, especially in patients with heart failure and acute coronary syndrome (ACS). High bleeding risk is also linked to coronary artery disease prognosis, including ACS. However, whether the extent of malnutrition and high bleeding [...] Read more.
Background: Malnutrition in cardiovascular disease is associated with poor prognosis, especially in patients with heart failure and acute coronary syndrome (ACS). High bleeding risk is also linked to coronary artery disease prognosis, including ACS. However, whether the extent of malnutrition and high bleeding risk have a cumulative impact on the long-term prognosis of patients with ACS who undergo percutaneous coronary intervention remains unclear. Methods: We analyzed 275 patients with ACS treated with percutaneous coronary intervention. The Controlling Nutritional Status score and Japanese version of the Academic Research Consortium for High Bleeding Risk criteria (J-HBR) were retrospectively evaluated. The primary and secondary outcomes were adjusted using the inverse probability treatment weighting method. Results: The prevalence of moderate or severe malnutrition in this cohort was 16%. Kaplan–Meier analysis showed a significantly higher incidence of major adverse cardiovascular and cerebrovascular events in patients who were moderately or severely malnourished than in those who were not. Notably, the incidence of these major events was similar between severely malnourished patients with J-HBR and those without. Conclusion: Moderate or severe malnutrition has a significant impact on the long-term prognosis of patients with ACS who undergo percutaneous coronary intervention. Full article
(This article belongs to the Special Issue Interventional Cardiology and Vascular Medicine)
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