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Article

An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study

by
Suresh Rao
1,
Sanath Kumar Hegde
1,
Manjeshwar Poonam Baliga-Rao
2,
Princy Louis Palatty
3,
Thomas George
3 and
Manjeshwar Shrinath Baliga
1,*
1
Department of Radiation Oncology, Mangalore Institute of Oncology, Mangalore 575002, India
2
Department of Pharmacy Division, Mangalore Institute of Oncology, Mangalore 575002, India
3
Department of Pharmacology, Father Muller Medical College, Kankanady, Mangalore 575002; India
*
Author to whom correspondence should be addressed.
Medicines 2017, 4(3), 44; https://doi.org/10.3390/medicines4030044
Submission received: 9 May 2017 / Revised: 14 June 2017 / Accepted: 19 June 2017 / Published: 24 June 2017
(This article belongs to the Special Issue Complementary and Alternative Medicine for Cancer Patients)
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Abstract

:
Background: This study was planned to evaluate the efficacy of topical application of an Aloe vera-based cream (AVC) for the prevention of ionizing radiation (X ray)-induced dermatitis in head and neck cancer patients requiring therapeutic radiation treatment (>62 Gy). Methods: From July 2012 to December 2012, a total of 60 head and neck cancer patients requiring curative radiotherapy (RT) of more than 66 Gy were prospectively enrolled and treated with AVC or a comparator Johnson’s Baby Oil (JBO). Acute skin reaction was monitored and classified according to the Radiation Therapy Oncology Group (RTOG) four-point rating scale on a weekly basis. Results: The results indicate that there was a statistically significant delay in the incidence (p = 0.04) of dermatitis at week three in the AVC application group. Application of AVC reduced the incidence of Grade 1, 2, and 3 dermatitis at subsequent time points, while Grade 4 dermatitis was not seen in either cohort. The other most important observation was that the continued application of AVC two weeks after the completion of RT was effective in reducing the average grade of dermatitis and was statistically significant (p < 0.02). Conclusions: Prophylactic use of an AVC-based cream is thus effective in delaying radiation dermatitis in head and neck cancer.

Graphical Abstract

1. Introduction

Head and neck cancers (H & N) are globally the sixth most common cancer and a major health burden [1]. The most important aspects of H & N cancers are that they are a heterogeneous group and include tumors growing in the oral cavity, pharynx, and larynx regions [2,3]. From a therapeutic perspective, surgery, chemotherapy, and radiotherapy are the most important treatment strategies and are used either alone or in combination to obtain complete remission and cure [3]. Of these, radiotherapy is extremely useful in the treatment of inoperable tumors and is used either alone or in combination with a small dose of chemotherapy (termed chemo-irradiation), usually cisplatin or carboplatin [3,4,5]. However, curative radiotherapy causes radiation-induced-dermatitis (also known as radiodermatitis) in most patients [6,7,8,9,10,11]. Conventionally, steroidal, non-steroidal, and metallic topical preparations and dressings are used to mitigate radiodermatitis [12,13]. However, in the recent past, skin care products containing extracts of Aloe vera [14,15,16], silymarin [17], and marigold [18] have been reported to be beneficial. Of these, Aloe vera has been investigated in detail in patients undergoing curative radiotherapy for their breast cancer [14,15,16].
The plant Aloe vera is one of the most well-researched plants in skin care and studies have shown it to be useful in the treatment of cuts, abrasions, burns, sunburns, and eczema [19]. Experimental studies with laboratory animals have also shown it to be effective in reducing UV radiation-induced skin erythema, inflammation [20], contact hypersensitivity (CHS), and delayed-type hypersensitivity (DTH) [21]. Aloe vera prevents chemical-induced skin carcinogenesis [22,23] and is also reported to be effective in preventing senescence [24], healing psoriasis [25], and enhancing the healing of partial thickness burn wounds [26].
Aloe vera has been investigated for its protective effects against radiodermatitis in women undergoing curative treatment for breast cancer, and the observations are contradictory [15,16,19]. From a dermatological perspective, the region of the head and neck is more susceptible to a severe degree of dermatitis as the region has skin folds and an undulated surface. This leads to diminished aesthetic appearance, is associated with pain, and affects the quality of life of the patient. For an agent to be beneficial, it is advisable that its pharmacological effects be studied in various anatomical areas. Considering this, the present study was carried out in patients requiring curative radiotherapy for their H & N cancers.

2. Materials and Methods

This was a single-center, investigator-blinded random sampling study and was conducted between July 2012 and December 2012 in the Department of Radiation Oncology at Mangalore Institute of Oncology, Pumpwell, Mangalore, India. The subjects comprised of histopathologically confirmed adult patients with head and neck cancer scheduled to receive radiotherapy or chemoradiotherapy. H & N cancer cases that had radical surgery prior to six weeks at the start of radiation treatment were also included. The other most important criteria were that only patients with a Karnofsky Performance Scale [27] of above 70 (patient can care for self but is unable to carry on normal activity or do active work) were included.
The exclusion criteria included patients less than 18 years of age; women with positive pregnancy test or lactating; patients on high doses of non-steroidal anti-inflammatory drugs; those with poor oral hygiene and significant co-morbidity (such as poorly controlled diabetes mellitus, hypertension, schizophrenia, bipolar disorders, and severe depression). Patients who had had oral surgery within the past six weeks, chemotherapy within the last eight weeks, or who had previously been treated with radiotherapy for cancers in the H & N regions were also excluded.
The study was approved by the Institutional Ethics Committee and was carried out in accordance with the guidelines of the Helsinki Declaration. Each patient and their caregivers had the treatment schedule, the benefits, and the possible adverse effects of the study explained by a trained professional in a private counseling room of the institute. They were also informed about their right to withdraw during the course of the study and that this would not affect their proposed treatment. Queries from both patients and caregivers were answered and written consent was obtained from all willing patients.

2.1. Patients and Methods

Willing patients fulfilling the inclusion criteria were randomized into either of two groups using opaque envelopes by an investigator unaware of the patient’s details. Patients allocated to Group 1 received JBO (Johnson’s Baby Oil), while Group 2 received AVC (Aloe vera-based cream).

2.2. Radiation Therapy Treatment

All patients who participated in this study received external irradiation from a linear accelerator (Varian, Model Unique Performance, Palo Alto, CA, USA) at a maximum energy level of 6 MV at a dose rate of 300 MU/min. All planned fields were treated every day with no more than one fraction of 2 Gy per day, five times a week, at the same time of day without any intended gaps, for a planned target dose of 66 Gy (seven consecutive weeks). Whenever chemo-irradiation was planned, carboplatin infusion (70 mg/m2/day intravenous) was administered on a weekly basis three hours before exposure to the first weekly radiation [28].

2.3. Application of JBO and AVC

AVC (Elovera, Glenmark, Mumbai, India) and JBO (Johnson & Johnson, Mumbai, India) were procured from designated dealers of the company and provided to the patient/ caregiver according to the randomization by one of the investigators. To avoid batch to batch variation a single lot of the required amount of the cream and oil were procured before the start of the study.
Prior to the start of radiation, the volunteers and their caregivers were also taught the correct way of applying the JBO (5 mL) or AVC (5 g) by one of the investigators. During the course of the treatment, the patients were also instructed to apply the cream five times a day (two hours before, immediately after, two hours after, four hours after, and six hours after radiotherapy). The application of the cream or oil was recommended to be performed with the ventral surface of the fingers using a rotary motion of the fingers with light pressure to the skin. The oil/cream was massaged into the skin until the surface of the skin no longer felt greasy. No other prophylactic creams, lotions, or gels were recommended/allowed during the study period. When moist desquamation occurred, the topical application of the JBO or AVC cream was discontinued in the affected area and 1% gentian violet paint was applied until the wound healed. However, the patients were advised to continue with the topical preparation of the JBO and the cream in the area of radiation that was free of moist desquamation. To preserve the single blinding, patients were instructed not to use the agent 2 h or less before an irradiation session or before evaluation by the doctor.
Patients of both cohorts were advised to use lukewarm water and a gentle detergent to wash and told not to shampoo their hair or scratch the irradiated skin; men were advised against using razor blades. They were instructed to use a head scarf or shawl to cover the skin from direct sunlight, pat the skin dry with a soft towel after washing, and keep the irradiated skin dry. During the course of the treatment, one of the investigators checked for the usage of the cream/oil on a weekly basis and repeatedly instructed volunteers in both groups to adhere to the application of the oil/cream. As one point of application was immediately after irradiation, it was easy for the investigators to keep a record of the patient’s adherence to oil/cream. A carefully planned diet was provided for all the patients.

2.4. Patient Evaluation

The patients of both groups were assessed for radiation-induced dermatitis by an experienced physician unaware of the experimental classification and dermatological treatment. The assessment was undertaken every week on Fridays in accordance with the criteria of the Radiation Therapy Oncology Group/European Organization for Research and Treatment Cancer (RTOG/EORTC) [29]. The criteria were as follows: Grade 0: no skin rending, ulceration, inflammation or damage; Grade 1: Faint erythema or dry desquamation; Grade 2: Moderate to brisk erythema, patchy moist desquamation mostly confined to skin folds and creases, moderate edema; Grade 3: radiation dermatitis consists of moist desquamation ≤1.5 cm diameter, other than skin folds or creases and bleeding induced by minor trauma or abrasion; and Grade 4: skin necrosis or ulceration of full thickness dermis; spontaneous bleeding from the involved site. This score makes a useful distinction between faint erythema and tender, bright erythema, as well as between patchy and confluent moist desquamation, and is probably the most widely used in practice and research [10,11]. At every investigation, the investigator considered the score for the worst toxicity in the treatment.

2.5. Statistical Analysis

The Student’s t-test was used to assess the difference in the degree of dermatitis at each time point, along with the delay in incidence and the number of dermatitis, while the x2 test was used to compare the total incidence of dermatitis using the online Vassar stat and Social Science Statistics program. A p value <0.05 was considered significant.

3. Results

The demographic information and the cancer details are represented in Table 1, respectively. With respect to the age, the mean age for the JBO group was 55.2 ± 9.66 (range 30–73), while for AVC it was 55.9 ± 8.99 (range 35–71) and was statistically not significant. The male to female ratio was 24:6 in the JBO and 26:4 for the AVC group, respectively. Tumor characteristics in the two groups are represented in Table 1. Of the 60 patients enrolled, 59 were available throughout the study period until two weeks post-irradiation (Figure 1). One patient in the JBO group died of cancer during the second week of treatment, giving an effective number of 59 for the study and 29 for the JBO arm of the cohort.
The radiation dermatitis was evaluated in accordance with the RTOG guidelines and at the end of the first and second week; patients in both groups had normal skin and did not show any indications of RTOG-specified radiodermatitis (Figure 2 and Figure 3). The incidence of dermatitis after the second week was as follows in the JBO group: 41.4% (12/29 week 3), 82.8% (24/29 week 4), 93.1% (27/29 week 5), 96.6% (28/29 week 6), 96.6% (28/29 week 7) and 86.2% (25/29) at two weeks post treatment; while in the AVC it was 16.7% (5/30 week 3); 70% (21/30 week 4); 90% (27/30 week 5); 90% (27/30 week 6); 90% (27/30 week 7); and 73.3% (22/30 week 8) at two weeks post-treatment. Analysis also showed that at the end of the study 96.55% (28/29) and 90.00% (27/30) of volunteers in the JBO and AVC groups developed dermatitis.
The incidence of Grade 1 dermatitis was seen in the third week: 41.40% (12/29) of the volunteers in the JBO group and 16.66% (5/30) in the AVC group, respectively, developed dermatitis, which was statistically significant (x2; p = 0.04) (Figure 2). Grade 2 dermatitis was first seen at the end of week 4 in both groups: 17.24% (5/29) and 13.33% (4/30) in JBO and AVC, respectively (Figure 2). Continuation of the radiation treatment increased the incidence and degree of dermatitis (Grades 2 and 3) in both groups (Figure 2 and Figure 3).
The highest dermatitis observed in the study was Grade 3; 34.48% (10/29) and 40.00% (12/30) developed it in the JBO and AVC cohorts, respectively, at week seven (Figure 2). In the JBO group, Grade 3 was observed as follows: 13.79% (4/29) at week 5; 17.25% (5/29) at week 6; and a peak of 34.48% (10/29) at week 7 (Figure 2). Application of AVC reduced the cases of patients with Grade 3 radiodermatitis: 3.33% (1/30) and 40.00% (12/30) incidence were observed at weeks 6 and 7, respectively (Figure 2). In this study, none of the 59 evaluable individuals developed Grade 4 dermatitis.
Observation of the incidence and grade of dermatitis two weeks after the completion of the treatment showed that when compared to the JBO the average grade of dermatitis was lower in the AVC group (1.2 ± 0.67 vs. 0.87 ± 0.6) and was statistically significant (p < 0.02) (Figure 3). The cohort applying AVC had a lower incidence of Grade 2 dermatitis [41.38% (12/29) vs. 13.33% (4/30)], which was statistically significant (p < 0.02).

4. Discussion

Radiodermatitis is an inevitable side effect observed during the course of ionizing radiation treatment; its mitigation is vital for the uninterrupted completion of the planned treatment [12,30]. From this study two important points can be inferred. The first is that applying an Aloe vera-based cream delays the incidence (Figure 2) and mitigates the grade (Figure 3) of dermatitis (when evaluated from the initiation of the treatment). The second observation is that continuing Aloe vera application after completion of the treatment enhances recovery by reducing the average degree of dermatitis (1.2 ± 0.67 vs. 0.87 ± 0.6) (Figure 3) and incidence of Grade 2 dermatitis (41.38% vs. 13.33%) (Figure 2).
Previous studies have shown that Aloe vera gel, when combined with mild soap, mitigates dermatitis in women undergoing radiation treatment for breast cancer [31]. However, the observation that an Aloe vera-based cream delays the incidence of dermatitis (when evaluated from the initiation of the treatment) is novel and indicates the usefulness of Aloe vera in enhancing the healing of radiation dermatitis. Together, both these observations indicate the usefulness of Aloe vera in delaying and mitigating dermatitis and promoting recovery.
The mechanism by which radiodermatitis develops is multifaceted and includes myriad overlapping events [32,33,34,35,36,37]. At a molecular level, exposure to X-rays, a low LET ionizing radiation, causes cell damage and death by generating free radicals and inducing DNA strand breaks [32,33]. Aloe vera is reported to be a potent antioxidant and inhibits TPA-induced ear edema and tumor promotion in mouse skin [38]. Further experiments with laboratory rats have also shown that Aloe saponaria Haw, a sister species of Aloe vera, was effective in decreasing UVB-induced nociception (allodynia and hyperalgesia), leukocyte infiltration, inflammation, and edema [35]. Additionally, methanol extracts of Aloe arborescens were effective in scavenging reactive oxygen and protecting DNA [36].
Aloe vera has been investigated for its radioprotective properties; studies have also shown that the Aloe vera leaf extract protects mice against radiation-induced sickness and lethality [37]. In this study it was observed that at week 6, the cohorts where AVC was applied had a lower incidence of Grade 3 dermatitis [17.25% (5/29) vs. 3.33% (1/30) Figure 2]. Although not significant (x2; p = 0.07), the result indicates that AVC was effective in delaying the development of Grade 3 dermatitis. Acute radiodermatitis is a primarily inflammatory reaction and pro-inflammatory cytokines, which are rapidly activated after tissue irradiation, play a major role in the radiation dermatitis [9,39]. Previous studies have shown that Aloe vera possesses anti-inflammatory effects that can be mediated by modulating the levels of cytokines and the relevant signal transduction pathway in various study models [40,41].
The other important observation was that application of AVC after the completion of radiation treatment was effective in reducing the incidence of Grade 2 dermatitis [41.38% (12/29) vs. 13.33% (4/30); p < 0.02; Figure 2) and the mean dermatitis score (1.2 ± 0.67 vs. 0.87 ± 0.6; p < 0.02; Figure 3). Scientific studies have shown Aloe vera to be effective in enhancing burn wound healing and a similar mechanism may be occurring here. Both these aspects needs to be validated and studies are being planned to validate the hypothesis. Aloe vera has been used as a wound healing agent for centuries [42,43,44,45,46,47,48,49] and, to substantiate our observations, studies have also shown that Aloe vera gel was effective in mitigating the adverse effects [48] and enhancing the wound healing process [49] in laboratory animals exposed to ionizing radiation; it also was effective at healing burn wounds in laboratory rats [46] and in humans [26]. In lieu of all these observations, and considering our observations, it can be postulated that Aloe vera reduced radiation-induced dermatitis, possibly by triggering anti-inflammatory and antioxidant responses, modulating cytokines, and enhancing the wound healing process. Mechanistic studies are being planned to validate our hypothesis with suitable models of study.

Acknowledgments

The authors are grateful to the management of Mangalore Institute of Oncology and its parent body the Mangalore Oncology Group for the financial assistance for the study to buy AVC and JBO from the vendors. The authors are also grateful to Poornima Thilak and Chetana Dinkar for helping in the recruitment of subjects and explaining the purpose of the study to the volunteers and their caregivers.

Author Contributions

For research articles with several authors, a short paragraph specifying their individual contributions must be provided. The following statements should be used S.R., S.K.H., M.P.B.-R., P.L.P. and M.S.B. conceived and designed the experiments; S.R., S.K.H. and M.P.B.-R. performed the experiments; M.S.B. and T.G. analyzed the data; S.R. contributed reagents/materials/analysis tools; S.R., P.L.P., T.G. and M.S.B. wrote the paper.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Jemal, A.; Bray, F.; Center, M.M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics. CA Cancer J. Clin. 2011, 61, 69–90. [Google Scholar] [CrossRef] [PubMed]
  2. World Health Organization (WHO). Oral Health Programme: Global Data on Incidence of Oral Cancer; WHO: Geneva, Switzerland, 2005. [Google Scholar]
  3. De Vita, V.T.; Lawrence, T.S.; Rosenberg, S.A. Cancer: Principles & Practice of Oncology, 8th ed.; Lippincott Williams & Wilkins: Baltimore, MD, USA, 2004. [Google Scholar]
  4. Mantovani, G.; Proto, E.; Massa, E.; Mulas, C.; Madeddu, C.; Mura, L. Induction chemotherapy followed by concomitant chemoradiation therapy in advanced head and neck cancer: A phase II study for organ-sparing purposes evaluating feasibility, effectiveness and toxicity. Int. J. Oncol. 2002, 20, 419–427. [Google Scholar] [CrossRef] [PubMed]
  5. Pignon, J.P.; Bourhis, J.; Domenge, C.; Designe, L. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: Three meta analyses of updated individual data. MACHNC Collaborative Group. Meta Analysis of Chemotherapy on Head and Neck Cancer. Lancet 2000, 355, 949–955. [Google Scholar] [CrossRef]
  6. Salvo, N.; Barnes, E.; van Draanen, J.; Stacey, E.; Mitera, G.; Breen, D.; Giotis, A.; Czarnota, G.; Pang, J.; De Angelis, C. Prophylaxis and management of acute radiation-induced skin reactions: A systematic review of the literature. Curr. Oncol. 2010, 17, 94–112. [Google Scholar] [PubMed]
  7. Glean, E.; Edwards, S.; Faithfull, S.; Meredith, C.; Richards, C.; Smith, M.; Colyer, H. Intervention for acute radiotherapy induced skin reactions in cancer patients: The development of a clinical guideline recommended for use by the college of radiographers. J. Radiother Pract. 2001, 2, 75–84. [Google Scholar] [CrossRef]
  8. Palatty, P.L.; Azmidah, A.; Rao, S.; Jayachander, D.; Thilakchand, K.R.; Rai, M.P.; Haniadka, R.; Simon, P.; Ravi, R.; Jimmy, R.; et al. Topical application of a sandal wood oil and turmeric based cream prevents radiodermatitis in head and neck cancer patients undergoing external beam radiotherapy: A pilot study. Br. J. Radiol. 2014, 87, 20130490. [Google Scholar] [CrossRef] [PubMed]
  9. Hymes, S.R.; Strom, E.A.; Fife, C. Radiation dermatitis: Clinical presentation, pathophysiology, and treatment 2006. J. Am. Acad. Dermatol. 2006, 54, 28–46. [Google Scholar] [CrossRef] [PubMed]
  10. Noble-Adams, R. Radiation-induced reactions 1: An examination of the phenomenon. Br. J. Nurs. 1999, 8, 1134–1140. [Google Scholar] [CrossRef] [PubMed]
  11. Noble-Adams, R. Radiation-induced reactions 2: Development of a measurement tool. Br. J. Nurs. 1999, 8, 1208–1211. [Google Scholar] [CrossRef] [PubMed]
  12. Bolderston, A.; Lloyd, N.; Wong, R.; Holden, L.; Robb-Blenderman, L. Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-Based Care. The prevention and management of acute skin reactions related to radiation therapy: A systematic review and practice guideline. Support. Care Cancer 2006, 14, 802–817. [Google Scholar] [CrossRef] [PubMed]
  13. Radvansky, L.J.; Pace, M.B.; Siddiqui, A. Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia. Am. J. Health Syst. Pharm. 2013, 70, 1025–1032. [Google Scholar] [CrossRef] [PubMed]
  14. Fisher, J.; Scott, C.; Stevens, R.; Marconi, B.; Champion, L.; Freedman, G.M.; Asrari, F.; Pilepich, M.V.; Gagnon, J.D.; Wong, G. Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG). Int. J. Radiat. Oncol. Biol. Phys. 2000, 48, 1307–1310. [Google Scholar] [PubMed]
  15. Olsen, D.L.; Raub, W.J.; Bradley, C.; Johnson, M.; Macias, J.L.; Love, V.; Markoem, A. The effect of Aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol. Nurs. Forum. 2001, 28, 543–547. [Google Scholar] [PubMed]
  16. Heggie, S.; Bryant, G.P.; Tripcony, L.; Keller, J.; Rose, P.; Glendenning, M.; Heath, J. A Phase III study on the efficacy of topical Aloe vera gel on irradiated breast tissue. Cancer Nurs. 2002, 25, 442–451. [Google Scholar] [CrossRef] [PubMed]
  17. Becker-Schiebe, M.; Mengs, U.; Schaefer, M.; Bulitta, M.; Hoffmann, W. Topical use of a silymarin-based preparation to prevent radiodermatitis: Results of a prospective study in breast cancer patients. Strahlenther Onkol. 2011, 187, 485–491. [Google Scholar] [CrossRef] [PubMed]
  18. Pommier, P.; Gomez, F.; Sunyach, M.P.; D’Hombres, A.; Carrie, C.; Montbarbon, X. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J. Clin. Oncol. 2004, 22, 1447–1453. [Google Scholar] [CrossRef] [PubMed]
  19. Haniadka, R.; Kamble, P.S.; Azmidha, A.; Mane, P.P.; Geevarughese, N.M.; Palatty, P.L.; Baliga, M.S. Review on the Use of Aloe vera (Aloe) in Dermatology; Watson, R.R., Zibadi, S., Eds.; Bioactive Dietary Factors and Plant Extracts in Dermatology; Springer: New York, NY, USA, 2013; pp. 125–136. [Google Scholar]
  20. Reuter, J.; Jocher, A.; Stump, J.; Grossjohann, B.; Franke, G.; Schempp, C.M. Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Skin Pharmacol. Physiol. 2008, 21, 106–110. [Google Scholar] [CrossRef] [PubMed]
  21. Strickland, F.M.; Pelley, R.P.; Kripke, M.L. Prevention of ultraviolet radiation-induced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract. J. Investig. Dermatol. 1994, 102, 197–204. [Google Scholar] [CrossRef] [PubMed]
  22. Chaudhary, G.; Saini, M.R.; Goyal, P.K. Chemopreventive potential of Aloe vera against 7,12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice. Integr. Cancer Ther. 2007, 6, 405–412. [Google Scholar] [CrossRef] [PubMed]
  23. Saini, M.; Goyal, P.K.; Chaudhary, G. Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice. J. Environ. Pathol. Toxicol. Oncol. 2010, 29, 127–135. [Google Scholar] [CrossRef] [PubMed]
  24. Cho, S.; Lee, S.; Lee, M.J.; Lee, D.H.; Won, C.H.; Kim, S.M.; Chung, J.H. Dietary Aloe vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Ann. Dermatol. 2009, 21, 6–11. [Google Scholar] [CrossRef] [PubMed]
  25. Paulsen, E.; Korsholm, L.; Brandrup, F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J. Eur. Acad. Dermatol Venereol. 2005, 19, 326–331. [Google Scholar] [CrossRef] [PubMed]
  26. Visuthikosol, V.; Chowchuen, B.; Sukwanarat, Y.; Sriurairatana, S.; Boonpucknavig, V. Effect of Aloe vera gel to healing of burn wound a clinical and histologic study. J. Med. Assoc. Thai. 1995, 78, 403–409. [Google Scholar] [PubMed]
  27. Schag, C.C.; Heinrich, R.L.; Ganz, P.A. Karnofsky performance status revisited: Reliability, validity, and guidelines. J. Clin. Oncol. 1984, 2, 187–193. [Google Scholar] [CrossRef] [PubMed]
  28. Rao, S.; Dinkar, C.; Vaishnav, L.K.; Rao, P.; Rai, M.P.; Fayad, R.; Baliga, M.S. The Indian Spice Turmeric Delays and Mitigates Radiation-Induced Oral Mucositis in Patients Undergoing Treatment for Head and Neck Cancer: An Investigational Study. Integr. Cancer Ther. 2014, 5, 201–210. [Google Scholar] [CrossRef] [PubMed]
  29. Cox, J.D.; Stetz, J.; Pajak, T.F. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int. J. Radiat. Oncol. Biol. Phys. 1995, 31, 1341–1346. [Google Scholar] [CrossRef]
  30. McQuestion, M. Evidence-based skin care management in radiation therapy. Sem. Oncol. Nurs. 2006, 22, 163–173. [Google Scholar] [CrossRef] [PubMed]
  31. Ryan, J.L. Ionizing radiation: The good, the bad, and the ugly. J. Investig. Dermatol. 2012, 132, 985–993. [Google Scholar] [CrossRef] [PubMed]
  32. Schaue, D.; Kachikwu, E.L.; McBride, W.H. Cytokines in radiobiological responses: A review. Radiat. Res. 2012, 178, 505–523. [Google Scholar] [CrossRef] [PubMed]
  33. Siomek, A. NF-κB signaling pathway and free radical impact. Acta Biochim. Pol. 2012, 59, 323–331. [Google Scholar] [PubMed]
  34. Harlev, E.; Nevo, E.; Lansky, E.P.; Ofir, R.; Bishayee, A. Anticancer potential of aloes: Antioxidant, antiproliferative, and immunostimulatory attributes. Planta Med. 2012, 78, 843–852. [Google Scholar] [PubMed]
  35. Silva, M.A.; Trevisan, G.; Hoffmeister, C.; Rossato, M.F.; Boligon, A.A.; Walker, C.I.; Klafke, J.Z.; Oliveira, S.M.; Silva, C.R.; Athayde, M.L.; et al. Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats. J. Photochem. Photobiol. B. 2014, 5, 47–54. [Google Scholar] [CrossRef] [PubMed]
  36. Shinoda, M. Studies on chemical radioprotectors against X-irradiation used by soft X-ray accelerator. Yakugaku Zasshi 1995, 115, 24–41. [Google Scholar] [CrossRef] [PubMed]
  37. Goyal, P.K.; Gehlot, P. Radioprotective effects of Aloe vera leaf extract on Swiss albino mice against whole-body gamma irradiation. J. Environ. Pathol. Toxicol. Oncol. 2009, 28, 53–61. [Google Scholar] [CrossRef] [PubMed]
  38. Shimpo, K.; Ida, C.; Chihara, T.; Beppu, H.; Kaneko, T.; Kuzuya, H. Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin. Phytother Res. 2002, 16, 491–493. [Google Scholar] [CrossRef] [PubMed]
  39. Sitton, E. Early and late radiation-induced skin alterations. Part I: Mechanism of skin changes. Oncol. Nurs. Forum. 1992, 19, 801–807. [Google Scholar] [PubMed]
  40. Duansak, D.; Somboonwong, J.; Patumraj, S. Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats. Clin. Hemorheol. Microcirc. 2003, 29, 239–246. [Google Scholar] [PubMed]
  41. Budai, M.M.; Varga, A.; Milesz, S.; Tőzsér, J.; Benkő, S. Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages. Mol. Immunol. 2013, 56, 471–479. [Google Scholar] [CrossRef] [PubMed]
  42. Jia, Y.; Zhao, G.; Jia, J. Preliminary evaluation: The effects of Aloe ferox Miller and Aloe arborescens Miller on wound healing. J. Ethnopharmacol. 2008, 120, 181–189. [Google Scholar] [CrossRef] [PubMed]
  43. Chithra, P.; Sajithlal, G.B.; Chandrakasan, G. Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats. J. Ethnopharmacol. 1998, 59, 179–186. [Google Scholar] [CrossRef]
  44. Chithra, P.; Sajithlal, G.B.; Chandrakasan, G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol. Cell Biochem. 1998, 181, 71–76. [Google Scholar] [CrossRef] [PubMed]
  45. Chithra, P.; Sajithlal, G.B.; Chandrakasan, G. Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats. Indian J. Exp. Biol. 1998, 36, 896–901. [Google Scholar] [PubMed]
  46. Hosseinimehr, S.J.; Khorasani, G.; Azadbakht, M.; Zamani, P.; Ghasemi, M.; Ahmadi, A. Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats. Acta Dermatovenerol Croat. 2010, 18, 2–7. [Google Scholar] [PubMed]
  47. Lv, R.L.; Wu, B.Y.; Chen, X.D.; Jiang, Q. The effects of aloe extract on nitric oxide and endothelin levels in deep-partial thickness burn wound tissue in rat. Zhonghua Shao Shang Za Zhi 2006, 22, 362–365. [Google Scholar] [PubMed]
  48. Roberts, D.B.; Travis, E.L. Acemannan-containing wound dressing gel reduces radiation-induced skin reactions in C3H mice. Int. J. Radiat. Oncol. Biol. Phys. 1995, 32, 1047–1052. [Google Scholar] [CrossRef]
  49. Atiba, A.; Nishimura, M.; Kakinuma, S.; Hiraoka, T.; Goryo, M.; Shimada, Y.; Ueno, H.; Uzuka, Y. Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production. Am. J. Surg. 2011, 201, 809–818. [Google Scholar] [CrossRef] [PubMed]
Medicines 04 00044 g001 550
Figure 1. Patient flow in the randomized controlled study.
Figure 1. Patient flow in the randomized controlled study.
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Figure 2. Incidence of dermatitis through the treatment period and two weeks after completion of treatment (x2 test @ = p < 0.02; * = p < 0.03; # = p < 0.04; $ = p = 0.07 (not significant)).
Figure 2. Incidence of dermatitis through the treatment period and two weeks after completion of treatment (x2 test @ = p < 0.02; * = p < 0.03; # = p < 0.04; $ = p = 0.07 (not significant)).
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Figure 3. Differences in the degree of radiation-induced dermatitis in the two groups during and after completion of radiation. Solid black bars represent JBO, while bricked bars represent AVC with the standard deviation. The lines above the bars are the standard deviation.
Figure 3. Differences in the degree of radiation-induced dermatitis in the two groups during and after completion of radiation. Solid black bars represent JBO, while bricked bars represent AVC with the standard deviation. The lines above the bars are the standard deviation.
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Table
Table 1. Patient and tumor characteristics.
Table 1. Patient and tumor characteristics.
DetailsJBO (Johnson’s Baby Oil)AVC (Aloe Vera-Based Cream)
Age (Yrs)55.2 ± 9.6655.9 ± 8.99
Gender
Male2426
Female64
Tumor Site
Alveolus21
Buccal mucosa21
glottis12
larynx23
Maxilla33
Pyriform sinus12
Pharynx (Oro and Hypo)31
Posterior cricoid11
Retromolar trigone11
Supraglottis55
Tongue67
Vocal cord33
TNM stage
Primary
T113
T21514
T31210
T413
TX1-
Regional nodes
N067
N11216
N243
N2a-2
N2b41
N2c3-
N32-
NX--
Metastasis
M02829
MX21
Radiation details
Dose of radiation (Gy)69.0 ± 1.967.0 ± 3.7
Total Fraction (in 7 weeks)34.3 ± 0.733.7 ± 1.9

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MDPI and ACS Style

Rao, S.; Hegde, S.K.; Baliga-Rao, M.P.; Palatty, P.L.; George, T.; Baliga, M.S. An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study. Medicines 2017, 4, 44. https://doi.org/10.3390/medicines4030044

AMA Style

Rao S, Hegde SK, Baliga-Rao MP, Palatty PL, George T, Baliga MS. An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study. Medicines. 2017; 4(3):44. https://doi.org/10.3390/medicines4030044

Chicago/Turabian Style

Rao, Suresh, Sanath Kumar Hegde, Manjeshwar Poonam Baliga-Rao, Princy Louis Palatty, Thomas George, and Manjeshwar Shrinath Baliga. 2017. "An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study" Medicines 4, no. 3: 44. https://doi.org/10.3390/medicines4030044

APA Style

Rao, S., Hegde, S. K., Baliga-Rao, M. P., Palatty, P. L., George, T., & Baliga, M. S. (2017). An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study. Medicines, 4(3), 44. https://doi.org/10.3390/medicines4030044

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