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Medicines, Volume 7, Issue 4

2020 April - 7 articles

Cover Story: Autologous bone marrow-derived stem cells (BMSCs) are capable of secretome release to injured cells, transfer of cytoplasmic structures, and neuronal transdifferentiation. The Stem Cell Ophthalmology Treatment Study using BMSCs demonstrated a statistically significant improvement in the vision of eyes with the dry form of age-related macular degeneration.View this paper.

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Articles (7)

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Case Report

2 Citations

11,737 Views

10 Pages

Limited Utility of Serology and Heterophile Test in the Early Diagnosis of Epstein–Barr Virus Mononucleosis in a Child after Renal Transplantation

Alexandra Byrne,
Rachel Bush,
Felicia Johns and
Kiran Upadhyay

Medicines2020, 7(4), 21;https://doi.org/10.3390/medicines7040021

22 April 2020

Background: Epstein–Barr virus (EBV) infection is associated with significant morbidity and mortality in renal transplant (RT) recipients. The spectrum of illness ranges from infectious mononucleosis (IM) to post-transplant lymphoproliferative disord...

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Article

5 Citations

6,742 Views

16 Pages

A Double-Blind Randomized Placebo-Controlled Study Assessing the Safety, Tolerability and Efficacy of a Herbal Medicine Containing Pycnogenol Combined with Papain and Aloe vera in the Prevention and Management of Pre-Diabetes

Luis Vitetta,
Belinda Butcher,
Serena Dal Forno,
Gemma Vitetta,
Tessa Nikov,
Sean Hall and
Elizabeth Steels

Medicines2020, 7(4), 22;https://doi.org/10.3390/medicines7040022

22 April 2020

Background: Herbal medicines present attractive options to patients with chronic diseases. Undertaking clinical studies with patients presenting with symptomless pre-T2D can lead to significant limitations. Methods: A 12-week randomized double-blind...

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Article

13 Citations

4,540 Views

7 Pages

Residential Aged Care Pharmacist: An Australian Pilot Trial Exploring the Impact on Quality Use of Medicines Indicators

Nicole McDerby,
Sam Kosari,
Kasia Bail,
Alison Shield,
Gregory Peterson and
Mark Naunton

Medicines2020, 7(4), 20;https://doi.org/10.3390/medicines7040020

20 April 2020

Background: This pilot study aimed to assess whether an on-site pharmacist could influence indicators of quality use of medicines in residential aged care. Methods: A pharmacist was embedded in a residential aged care home for six months. A similar c...

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Article

27 Citations

6,441 Views

16 Pages

Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

Leonardo Marques da Fonseca,
Lucas Rodrigues Jacques da Silva,
Jhenifer Santos dos Reis,
Marcos André Rodrigues da Costa Santos,
Victoria de Sousa Chaves,
Kelli Monteiro da Costa,
Julliana de Nazareth Sa-Diniz,
Celio Geraldo Freire de Lima,
Alexandre Morrot and
Leonardo Freire-de-Lima
+ 5 authors

Medicines2020, 7(4), 19;https://doi.org/10.3390/medicines7040019

8 April 2020

Background: Piperine, an amide extracted from the Piper spices, exhibits strong anti-tumor properties. However, its effect on the epithelial–mesenchymal transition (EMT) process has never been investigated. Herein, we evaluate the toxic effect...

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Article

5 Citations

5,117 Views

19 Pages

Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue

Wiem Haj Ahmed,
Cécile Peiro,
Jessica Fontaine,
Barry J. Ryan,
Gemma K. Kinsella,
Jeff O’Sullivan,
Jean-Louis Grolleau,
Gary T.M. Henehan and
Christian Carpéné

Medicines2020, 7(4), 18;https://doi.org/10.3390/medicines7040018

2 April 2020

Background: Methylxanthines including caffeine and theobromine are widely consumed compounds and were recently shown to interact with bovine copper-containing amine oxidase. To the best of our knowledge, no direct demonstration of any interplay betwe...

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Protocol

3 Citations

11,862 Views

9 Pages

Acupuncture for Relief of Gag Reflex in Patients Undergoing Transoesophageal Echocardiography—A Protocol for a Randomized Placebo-Controlled Trial

Taras I. Usichenko,
Irina Müller-Kozarez,
Stephan Knigge,
Raila Busch and
Mathias Busch

Medicines2020, 7(4), 17;https://doi.org/10.3390/medicines7040017

31 March 2020

Background: Gagging during transesophageal echocardiography examination (TEE) can be distressing and even dangerous for patients. The needling of acupuncture point CV24 was described to be effective in reducing the gag reflex during TEE in patients w...

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Article

24 Citations

8,953 Views

13 Pages

Stem Cell Ophthalmology Treatment Study (SCOTS): Bone Marrow-Derived Stem Cells in the Treatment of Age-Related Macular Degeneration

Jeffrey N. Weiss and
Steven Levy

Medicines2020, 7(4), 16;https://doi.org/10.3390/medicines7040016

28 March 2020

Background: Dry age-related macular degeneration (AMD) is one of the leading causes of vision loss in older patients. The macula accumulates drusen with loss of retinal pigment epithelial cells and photoreceptors. Abnormal subretinal neovascularizati...

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