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Medicines, Volume 9, Issue 2

2022 February - 9 articles

Cover Story: In this study, we report the synthesis of several novel artemisinin derivatives and evaluate their in vitro and in silico capacity to counteract Plasmodium falciparum artemisinin resistance. The present report demonstrates, in vitro, that FM-AZ, a newly synthesized artemisinin derivative, has a lower IC50 than artemisinin in P. falciparum and a rapid action in killing parasites. The docking studies for important parasite protein targets PfATP6 and PfHDP complemented the in vitro results, explaining the superior IC50 values of FM-AZ in comparison with ART obtained for the ART-resistant strain. However, cross-resistance between FM-AZ and artemisinins was evidenced in vitro. View this paper
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Articles (9)

  • Review
  • Open Access
10 Citations
9,113 Views
16 Pages
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Neurogenic Dysphagia and Nutrition in Disorder of Consciousness: An Overview with Practical Advices on an “Old” but Still Actual Clinical Problem

  • Loredana Raciti,
  • Gianfranco Raciti,
  • Grazia Pulejo,
  • Valeria Conti-Nibali and
  • Rocco Salvatore Calabrò
Medicines2022, 9(2), 16;https://doi.org/10.3390/medicines9020016

21 February 2022

Neurogenic dysphagia is a difficulty in swallowing food caused by disease or impairment of the nervous system, including stroke and traumatic brain injury. The most clinically apparent complication of neurogenic dysphagia is pulmonary aspiration, whi...

Full Article
  • Article
  • Open Access
6 Citations
5,634 Views
14 Pages
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Early Time-Restricted Feeding Amends Circadian Clock Function and Improves Metabolic Health in Male and Female Nile Grass Rats

  • Chidambaram Ramanathan,
  • Hayden Johnson,
  • Suman Sharma,
  • Wangkuk Son,
  • Melissa Puppa,
  • Saba Neyson Rohani,
  • Aaryani Tipirneni-Sajja,
  • Richard J. Bloomer and
  • Marie van der Merwe
Medicines2022, 9(2), 15;https://doi.org/10.3390/medicines9020015

21 February 2022

Lengthening the daily eating period contributes to the onset of obesity and metabolic syndrome. Dietary approaches, including energy restriction and time-restricted feeding, are promising methods to combat metabolic disorders. This study explored the...

Full Article
  • Article
  • Open Access
1 Citations
3,297 Views
11 Pages
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CHRIST: CD44-Incorporated Hepatocellular Carcinoma Risk Index Scoring Tool—A Novel Prognostic Scoring System for Hepatocellular Carcinoma Development and Aggressiveness

  • Ahmed Ali Khalifa,
  • Nermeen Abdeen,
  • Neveen L. Mikhael,
  • Sawsan Elmalah and
  • Ayman Elshayeb
Medicines2022, 9(2), 14;https://doi.org/10.3390/medicines9020014

21 February 2022

CD44 has been demonstrated to play a pivotal role in regulating tumor cell progression, including hepatocellular carcinoma (HCC) development. Here, we aimed to establish a scoring system to evaluate the risk of developing HCC utilizing CD44-rs187115...

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  • Article
  • Open Access
5 Citations
12,651 Views
10 Pages
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The Medial Surface of the Auricle: Historical and Recent Maps. What Are the Possible Expectations of the “Thumb-Index Technique”

  • Antonello Lovato,
  • Francesco Ceccherelli,
  • Giuseppe Gagliardi and
  • Marco Postiglione
Medicines2022, 9(2), 13;https://doi.org/10.3390/medicines9020013

17 February 2022

Introduction: The medial surface of the auricle (MSotA), as compared to the lateral, has been less studied and has limited consensus among schools of auricular acupuncture (AA) due to its small size, greater difficulty in carrying out an adequate phy...

Full Article
  • Case Report
  • Open Access
10 Citations
3,786 Views
12 Pages
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Potential Application of Lung Ultrasound in Children with Severe Uncontrolled Asthma: Preliminary Hypothesis Based on a Case Series

  • Cristina De Rose,
  • Stefano Miceli Sopo,
  • Piero Valentini,
  • Rosa Morello,
  • Daniele Biasucci and
  • Danilo Buonsenso
Medicines2022, 9(2), 11;https://doi.org/10.3390/medicines9020011

2 February 2022

In recent years, lung ultrasound (LUS) has been increasingly used for the diagnosis of respiratory diseases in both adult and pediatric patients. However, asthma is a field in which the use of LUS is not yet well defined, or is in development. In the...

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  • Article
  • Open Access
4 Citations
5,087 Views
18 Pages
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Ethnobotanical and Phytochemical Profiling of Medicinal Plants from Burkina Faso Used to Increase Physical Performance

  • Hemayoro Sama,
  • Modeste Traoré,
  • Samson Guenné,
  • Ibrahim Séré,
  • Adama Hilou and
  • Mamoudou H. Dicko
Medicines2022, 9(2), 10;https://doi.org/10.3390/medicines9020010

28 January 2022

Background: Some ergogenic medicinal plants are used in exercise and sport in Africa in order to increase sport performance. However, data on their composition and their possible impacts on health are limited. This study was initiated to provide ethn...

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  • Article
  • Open Access
3 Citations
3,675 Views
11 Pages
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Identification of Antimycobacterial Natural Products from a Library of Marine Invertebrate Extracts

  • Kojo Sekyi Acquah,
  • Denzil R. Beukes,
  • Ronnett Seldon,
  • Audrey Jordaan,
  • Suthananda N. Sunassee,
  • Digby F. Warner and
  • David W. Gammon
Medicines2022, 9(2), 9;https://doi.org/10.3390/medicines9020009

28 January 2022

Tuberculosis (TB) remains a public health crisis, requiring the urgent identification of new anti-mycobacterial drugs. We screened several organic and aqueous marine invertebrate extracts for their in vitro inhibitory activity against the causative o...

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  • Article
  • Open Access
7 Citations
4,037 Views
12 Pages
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In Vitro and In Silico Antimalarial Evaluation of FM-AZ, a New Artemisinin Derivative

  • Ioannis Tsamesidis,
  • Farnoush Mousavizadeh,
  • Chinedu O. Egwu,
  • Dionysia Amanatidou,
  • Antonella Pantaleo,
  • Françoise Benoit-Vical,
  • Karine Reybier and
  • Athanassios Giannis
Medicines2022, 9(2), 8;https://doi.org/10.3390/medicines9020008

24 January 2022

Artemisinin-based Combination Therapies (ACTs) are currently the frontline treatment against Plasmodium falciparum malaria, but parasite resistance to artemisinin (ART) and its derivatives, core components of ACTs, is spreading in the Mekong countrie...

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