Novel Computed Tomography Angiography Parameter Is Associated with Low Cardiac Index in Patients with Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Population
2.2. CT Acquisition and Measurements
2.3. Statistical Analysis
3. Results
3.1. Basic Demographics, Comorbidities, and Hemodynamics of the CTEPH Cohort
3.2. Hounsfield Units and Gradients
3.3. Fractional Reduction of HU
3.4. Pulmonary Vein Sign
3.5. Interobserver Variability
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variable | All (n = 237) n(%) or Mean ± SD | Normal CI n = 88 n(%) or Mean ± SD | Low CI n = 149 n(%) or Mean ± SD | p Value |
---|---|---|---|---|
Female | 119 (50.2%) | 58 (65.9%) | 61 (40.9%) | 0.001 |
Race/Ethnicity | ||||
White | 126 (53.2%) | 46 (52.3%) | 80 (53.7%) | 0.372 |
Black | 87 (36.7%) | 29 (34.1%) | 58 (39.5%) | |
Latinx | 17 (7.2%) | 10 (11.4%) | 7 (4.7%) | |
Age (years) | 60 ± 14.5 | 59 ± 16 | 60 ± 14 | 0.776 |
BMI (kg/m2) | 30.1 ± 8.1 | 31.4 ± 7.3 | 31.2 ± 8.4 | 0.642 |
WHO FC | ||||
I | 16 (6.8%) | 6 (6.8%) | 10 (6.7%) | 0.607 |
II | 71 (30%) | 29 (33%) | 42 (28%) | |
III | 120 (50.6%) | 45 (51.1%) | 75 (50.3%) | |
IV | 30 (12.7%) | 8 (9.1%) | 22 (14.8%) | |
Comorbidities | ||||
Atrial fibrillation | 32 (13.5%) | 14 (17%) | 18 (18.5%) | 0.358 |
Diabetes mellitus | 45 (19%) | 15 (17.4%) | 30 (20.1%) | 0.613 |
History of coagulopathy | 54 (21.8%) | 19 (22.6%) | 31 (20.9%) | 0.766 |
History of DVT | 121 (51.1%) | 42 (51.2%) | 79 (53.7%) | 0.714 |
History of PE | 185 (78.1%) | 63 (74%) | 122 (83%) | 0.105 |
Sleep Disorder | 55 (23.2%) | 14 (16.7%) | 41 (27.7%) | 0.057 |
PH medication | 82 (23.2%) | 34 (38.6%) | 48 (32.2%) | 0.218 |
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Oliveros, E.; Ibrahim, M.; Romero, C.M.; Navo, P.; Otero Valdes, P.; Brailovsky, Y.; Darki, A.; Bashir, R.; Vaidya, A.; Forfia, P.; et al. Novel Computed Tomography Angiography Parameter Is Associated with Low Cardiac Index in Patients with Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis. J. Cardiovasc. Dev. Dis. 2024, 11, 281. https://doi.org/10.3390/jcdd11090281
Oliveros E, Ibrahim M, Romero CM, Navo P, Otero Valdes P, Brailovsky Y, Darki A, Bashir R, Vaidya A, Forfia P, et al. Novel Computed Tomography Angiography Parameter Is Associated with Low Cardiac Index in Patients with Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis. Journal of Cardiovascular Development and Disease. 2024; 11(9):281. https://doi.org/10.3390/jcdd11090281
Chicago/Turabian StyleOliveros, Estefania, Michel Ibrahim, Carlos Manuel Romero, Paul Navo, Patricia Otero Valdes, Yevgeniy Brailovsky, Amir Darki, Riyaz Bashir, Anjali Vaidya, Paul Forfia, and et al. 2024. "Novel Computed Tomography Angiography Parameter Is Associated with Low Cardiac Index in Patients with Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis" Journal of Cardiovascular Development and Disease 11, no. 9: 281. https://doi.org/10.3390/jcdd11090281
APA StyleOliveros, E., Ibrahim, M., Romero, C. M., Navo, P., Otero Valdes, P., Brailovsky, Y., Darki, A., Bashir, R., Vaidya, A., Forfia, P., & Dass, C. (2024). Novel Computed Tomography Angiography Parameter Is Associated with Low Cardiac Index in Patients with Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Analysis. Journal of Cardiovascular Development and Disease, 11(9), 281. https://doi.org/10.3390/jcdd11090281