Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Ethical Statement and Recruitment
2.3. Clinical, Biological, and Genetic Data
2.4. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Total | Female Mean (SD) | Male Mean (SD) | p | |
---|---|---|---|---|
N = 460 | N = 292 | N = 168 | ||
Age | 40.60 (14.16) | 39.80 (12.85) | 41.98 (16.13) | 0.1118 |
BMI (Kg/m2) | 25.71 (4.98) | 24.53 (4.56) | 27.78 (5.02) | <0.001 |
Total cholesterol (mg/dl) | 181.41 (40.94) | 185.86 (40.68) | 173.69 (40.36) | 0.0021 |
HDL-C (mg/dl) | 45.54 (14.61) | 48.46 (14.71) | 40.45 (12.97) | <0.001 |
LDL-C (mg/dl) | 117.39 (33.52) | 120.28 (34.10) | 112.37 (31.99) | 0.0147 |
25(OH)D (ng/mL) | 24.53 (13.81) | 25.62 (17.56) | 22.64 (9.26) | 0.0253 |
Genotype | ||||
rs10741657G>A in CYP2R1 | ||||
GG | 206 (50.4) | 129 (50.4) | 77 (50.3) | 0.71 |
AG | 165 (40.3) | 101 (39.5) | 64 (41.8) | |
AA | 38 (9.3) | 26 (10.3) | 12 (7.8) | |
rs12785878T>G in NADSYN1/DHCR7 | ||||
TT | 116 (27.0) | 73 (26.8) | 43 (27.4) | 0.77 |
GT | 211 (49.2) | 137 (50.4) | 74 (47.1) | |
GG | 102 (23.8) | 62 (22.8) | 40 (25.5) | |
rs4588C>A in GC | ||||
CC | 267 (62.2) | 166 (61.3) | 101 (63.9) | 0.48 |
AC | 140 (32.6) | 93 (34.3) | 47 (29.7) | |
AA | 22 (5.1) | 12 (4.4) | 10 (6.3) | |
rs2282679A>C in GC | ||||
AA | 272 (62.5) | 172 (62.1) | 100 (63.3) | 0.35 |
CA | 143 (32.9) | 95 (34.3) | 48 (30.4) | |
CC | 20 (4.6) | 10 (3.6) | 10 (6.3) | |
rs4423214T>C in NADSYN1/DHCR7 | ||||
TT | 114 (26.4) | 73 (26.4) | 41 (26.5) | 0.74 |
CT | 215 (49.8) | 141 (50.9) | 74 (47.7) | |
CC | 103 (23.8) | 63 (22.7) | 40 (25.8) | |
rs4944062T>G in NADSYN1/DHCR7 | ||||
TT | 115 (27.3) | 74 (27.4) | 41 (27.0) | 0.54 |
GT | 211 (50.0) | 139 (51.5) | 72 (47.4) | |
GG | 96 (22.7) | 57 (21.1) | 39 (25.7) |
LDL-C | ||
---|---|---|
β (95%CI) | p-Value | |
rs10741657A | 4.95 (0.20; 9.70) | 0.04 |
Age | 0.54 (0.32; 0.76) | <0.0001 |
Physical activity | ||
<1 week | Reference | |
1 week | −1.39 (−1.06; −1.72) | <0.0001 |
Gender | ||
Female | Reference | |
Male | −1.40 (−1.84; −1.96) | 0.004 |
Smoking | ||
No | Reference | |
Yes | −1.41 (−1.97; −1.86) | 0.003 |
HDL-C | ||
rs10741657A | −1.76 (−1.76; −1.77) | 0.007 |
Gender | ||
Female | Reference | |
Male | −1.37 (−1.24; −1.50) | <0.0001 |
Smoking | ||
No | Reference | |
Yes | 3.57 (2.10; 5.06) | <0.0001 |
BMI | −1.43 (−1.71; −1.15) | 0.003 |
LDL-C | ||
---|---|---|
β (95%CI) | p-Value | |
Male | ||
rs10741657 | 1.03 (−1.89; 7.96) | 0.77 |
Age | 0.47 (0.19; 0.75) | 0.001 |
Alcohol | ||
No | Reference | |
Yes | −1.25 (−1.80; −1.69) | 0.002 |
Female | ||
rs10741657 | 6.73 (0.61; 12.86) | 0.03 |
Age | 0.41 (0.09; 0.73) | 0.01 |
Physical activity | ||
<1 week | Reference | |
1 week | −1.88 (−1.47; −1.29) | <0.0001 |
>1 week | −1.38 (−1.04; −1.73) | 0.02 |
BMI | −1.75 (−1.66; −1.84) | <0.0001 |
rs10741657*gender interaction | 0.005 |
HDL-C | ||
---|---|---|
β (95%CI) | p-Value | |
Male | ||
rs10741657 | −1.09 (−1.15; −1.04) | 0.009 |
Age | 0.18 (0.06; 0.30) | 0.004 |
smoking | ||
No | Reference | |
Yes | 4.04 (1.65; 6.44) | 0.001 |
BMI | −1.48 (−1.89; −1.08) | 0.02 |
Female | ||
rs10741657 | −1.77 (−1.32; 0.77) | 0.17 |
Age | −1.23 (−1.36; −1.10) | 0.001 |
smoking | ||
No | Reference | |
Yes | 3.79 (1.89; 5.69) | <0.0001 |
BMI | −1.39 (−1.77; −1.01) | 0.04 |
rs10741657A*gender interaction | <0.0001 |
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Fakhoury, H.M.A.; El Shamieh, S.; Rifai, A.; Tamim, H.; Fakhoury, R. Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population. J. Cardiovasc. Dev. Dis. 2022, 9, 102. https://doi.org/10.3390/jcdd9040102
Fakhoury HMA, El Shamieh S, Rifai A, Tamim H, Fakhoury R. Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population. Journal of Cardiovascular Development and Disease. 2022; 9(4):102. https://doi.org/10.3390/jcdd9040102
Chicago/Turabian StyleFakhoury, Hana M. A., Said El Shamieh, Amru Rifai, Hani Tamim, and Rajaa Fakhoury. 2022. "Vitamin D Related Gene Polymorphisms and Cholesterol Levels in a Mediterranean Population" Journal of Cardiovascular Development and Disease 9, no. 4: 102. https://doi.org/10.3390/jcdd9040102