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Volume 11
Issue 2
10.3390/gels11020104
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling

by
Fei Ran
†,
Kailang Mu
†,
Lingli Zhou
,
Leqiang Peng
,
Gang Liu
*,
Yuchen Liu
*,
Yuxin Pang
,
Guo Feng
,
Changmao Guo
,
Tianjian Wang
and
Qiumei Luo
College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work and are co-first authors.
Gels 2025, 11(2), 104; https://doi.org/10.3390/gels11020104
Submission received: 7 January 2025 / Revised: 12 January 2025 / Accepted: 27 January 2025 / Published: 2 February 2025
(This article belongs to the Special Issue Advances in Gels for Wound Treatment)
Versions Notes

Abstract

Diabetic wound healing presents significant challenges due to impaired angiogenesis, chronic inflammation, and cellular dysfunction. Building on previous research, this study further explores the potential of a plant-derived glucosyloxybenzyl 2-isobutylmalates (B-CGT) hydrogel in promoting diabetic wound healing. Network pharmacology and molecular docking analyses suggest that B-CGT may regulate key mechanisms, such as apoptosis, inflammation, and matrix remodeling, through core targets including SIRT1, CASP8, and MMP8. In vivo studies further demonstrated that B-CGT hydrogel significantly accelerated wound closure in diabetic mice, enhanced angiogenesis, promoted collagen deposition, and achieved immune balance by modulating macrophage polarization, thereby shifting the inflammatory environment toward a repair state. Moreover, B-CGT hydrogel significantly improved the wound microenvironment by upregulating VEGF expression and exerting antioxidant effects. By combining theoretical predictions with experimental validation, this study elucidates the multi-target synergistic regulatory mechanisms of B-CGT hydrogel. These findings provide new research directions for addressing immune imbalance and angiogenesis defects in diabetic wound healing and lay a scientific foundation for the optimization and application of chronic wound treatment strategies.
Keywords: diabetic wound healing; B-CGT hydrogel; mechanism of action; network pharmacology; molecular docking diabetic wound healing; B-CGT hydrogel; mechanism of action; network pharmacology; molecular docking

Share and Cite

MDPI and ACS Style

Ran, F.; Mu, K.; Zhou, L.; Peng, L.; Liu, G.; Liu, Y.; Pang, Y.; Feng, G.; Guo, C.; Wang, T.; et al. Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling. Gels 2025, 11, 104. https://doi.org/10.3390/gels11020104

AMA Style

Ran F, Mu K, Zhou L, Peng L, Liu G, Liu Y, Pang Y, Feng G, Guo C, Wang T, et al. Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling. Gels. 2025; 11(2):104. https://doi.org/10.3390/gels11020104

Chicago/Turabian Style

Ran, Fei, Kailang Mu, Lingli Zhou, Leqiang Peng, Gang Liu, Yuchen Liu, Yuxin Pang, Guo Feng, Changmao Guo, Tianjian Wang, and et al. 2025. "Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling" Gels 11, no. 2: 104. https://doi.org/10.3390/gels11020104

APA Style

Ran, F., Mu, K., Zhou, L., Peng, L., Liu, G., Liu, Y., Pang, Y., Feng, G., Guo, C., Wang, T., & Luo, Q. (2025). Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling. Gels, 11(2), 104. https://doi.org/10.3390/gels11020104

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