Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil
Abstract
:1. Introduction
2. Results and Discussion
2.1. Hydrogel Characterization
2.2. Nanostructure Morphology
2.3. Spectroscopic Study of Peptide Conformation
2.4. Drug Release Studies
2.5. Molecular Modeling of d-Leu-Phe-Phe/5-FU Interaction
3. Conclusions
4. Materials and Methods
4.1. Materials
4.2. Peptide Synthesis and Purification
4.3. Hydrogel Preparation
4.4. Oscillatory Rheometry
4.5. Transmission Electron Microscopy
4.6. Circular Dichroism
4.7. Fourier-Transformed Infrared Spectroscopy
4.8. Thioflavin T Fluorescence Assay
4.9. Drug Release Assay
4.10. Molecular Modeling
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Parisi, E.; Garcia, A.M.; Marson, D.; Posocco, P.; Marchesan, S. Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil. Gels 2019, 5, 5. https://doi.org/10.3390/gels5010005
Parisi E, Garcia AM, Marson D, Posocco P, Marchesan S. Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil. Gels. 2019; 5(1):5. https://doi.org/10.3390/gels5010005
Chicago/Turabian StyleParisi, Evelina, Ana M. Garcia, Domenico Marson, Paola Posocco, and Silvia Marchesan. 2019. "Supramolecular Tripeptide Hydrogel Assembly with 5-Fluorouracil" Gels 5, no. 1: 5. https://doi.org/10.3390/gels5010005