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Volume 7
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10.3390/gels7040152
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Review

Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides

by
Meng Zhang
1,2,3,†,
Lei Li
4,†,
Heng An
5,
Peixun Zhang
1,2,3,* and
Peilai Liu
4,*
1
Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, China
2
Key Laboratory of Trauma and Neural Regeneration, Peking University, Beijing 100044, China
3
National Center for Trauma Medicine, Beijing 100044, China
4
Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan 250012, China
5
Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing 100044, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed to this work equally.
Gels 2021, 7(4), 152; https://doi.org/10.3390/gels7040152
Submission received: 7 August 2021 / Revised: 20 September 2021 / Accepted: 23 September 2021 / Published: 27 September 2021
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Abstract

Peripheral nerve injury often occurs in young adults and is characterized by complex regeneration mechanisms, poor prognosis, and slow recovery, which not only creates psychological obstacles for the patients but also causes a significant burden on society, making it a fundamental problem in clinical medicine. Various steps are needed to promote regeneration of the peripheral nerve. As a bioremediation material, self-assembled peptide (SAP) hydrogels have attracted international attention. They can not only be designed with different characteristics but also be applied in the repair of peripheral nerve injury by promoting cell proliferation or drug-loaded sustained release. SAP hydrogels are widely used in tissue engineering and have become the focus of research. They have extensive application prospects and are of great potential biological value. In this paper, the application of SAP hydrogel in peripheral nerve injury repair is reviewed, and the latest progress in peptide composites and fabrication techniques are discussed.
Keywords: self-assembled peptides; peripheral nerve injury; design and production process; nerve regeneration; natural polymers self-assembled peptides; peripheral nerve injury; design and production process; nerve regeneration; natural polymers
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MDPI and ACS Style

Zhang, M.; Li, L.; An, H.; Zhang, P.; Liu, P. Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides. Gels 2021, 7, 152. https://doi.org/10.3390/gels7040152

AMA Style

Zhang M, Li L, An H, Zhang P, Liu P. Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides. Gels. 2021; 7(4):152. https://doi.org/10.3390/gels7040152

Chicago/Turabian Style

Zhang, Meng, Lei Li, Heng An, Peixun Zhang, and Peilai Liu. 2021. "Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides" Gels 7, no. 4: 152. https://doi.org/10.3390/gels7040152

APA Style

Zhang, M., Li, L., An, H., Zhang, P., & Liu, P. (2021). Repair of Peripheral Nerve Injury Using Hydrogels Based on Self-Assembled Peptides. Gels, 7(4), 152. https://doi.org/10.3390/gels7040152

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