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Article
Peer-Review Record

Thermosensitive Chitosan-Containing Hydrogels: Their Formation, Properties, Antibacterial Activity, and Veterinary Usage

by Natalia O. Gegel 1, Anna B. Shipovskaya 1,*, Zaur Yu. Khaptsev 2, Roman V. Radionov 3, Anastasia A. Belyaeva 1 and Vitaly N. Kharlamov 1
Reviewer 1: Anonymous
Reviewer 2:
Submission received: 14 December 2021 / Revised: 16 January 2022 / Accepted: 2 February 2022 / Published: 4 February 2022
(This article belongs to the Special Issue Chitosan Functional Hydrogels: Synthesis and Applications)

Round 1

Reviewer 1 Report

This manuscript describes the preparation of thermosensitive hydrogels by mixing mucoadhesive polymer chitosan with the thermosensitive polymer Pluronic F 127. In addition, D-ascorbic acid was added to the hydrogel and used as a comparison to the primary hydrogels. The hydrogels were examined for their rheology properties, in vitro antibacterial activity, and in vivo anti vaginal infection study. The manuscript was not written well, with too many grammatical errors, which made it inconvenient to read. Here are some of the major comments that need to be addressed.

Comments for author File: Comments.pdf

Author Response

Пожалуйста, смотрите вложение.

Author Response File: Author Response.pdf

Reviewer 2 Report

Dear authors,

I appreciate your effort in designing thermosensitive chitosan-Pluronic F127 hydrogels. Though the research idea is good, you must improve your discussion part for better presentation of results. Please answer the comments to improve the quality of the manuscript.

Thanks and good luck.

Comments for author File: Comments.pdf

Author Response

Пожалуйста, смотрите вложение.

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

no comment

Reviewer 2 Report

Article can be accepted

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