PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement
Abstract
:1. Introduction
2. Results
2.1. Morphology
2.2. Water Uptake
2.3. Wettability
2.4. Mechanical Behavior
2.5. Rheological Behavior
2.6. Friction Coefficient
2.7. Drug Loading and Release
2.8. HET-CAM Test
3. Discussion
4. Conclusions
- (1)
- PAA was added to the formulation of hydrogels to obtain PVA/PAA samples;
- (2)
- PVA/PAA was further immersed in PEG to obtain PVA/PAA+PEG samples;
- (3)
- PVA/PAA+PEG was annealed at 120 °C, giving rise to PVA/PAA+PEG+A samples.
5. Materials and Methods
5.1. Materials
5.2. Methods
5.2.1. Samples Preparation
Hydrogels
Cartilage
5.2.2. Samples Characterization
Morphology
Water Uptake
Wettability
Mechanical Behavior
Rheological Behavior
Friction Coefficient
Drug Loading and Release
HET–CAM Test
Statistics
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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PVA | PVA/PAA | PVA/PAA+PEG | PVA/PAA+PEG+A | |
---|---|---|---|---|
DFN amount loaded (μg DFN/mg dry sample) | 14.6 ± 0.9 | 125.5 ± 9.2 | 77.9 ± 4.8 | 81.7 ± 11.6 |
DFN released (%) | 57.8 ± 3.6 | 45.7 ± 3.3 | 64.3 ± 4.0 | 55.3 ± 7.9 |
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Branco, A.C.; Oliveira, A.S.; Monteiro, I.; Nolasco, P.; Silva, D.C.; Figueiredo-Pina, C.G.; Colaço, R.; Serro, A.P. PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement. Gels 2022, 8, 143. https://doi.org/10.3390/gels8030143
Branco AC, Oliveira AS, Monteiro I, Nolasco P, Silva DC, Figueiredo-Pina CG, Colaço R, Serro AP. PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement. Gels. 2022; 8(3):143. https://doi.org/10.3390/gels8030143
Chicago/Turabian StyleBranco, Ana C., Andreia S. Oliveira, Inês Monteiro, Pedro Nolasco, Diana C. Silva, Célio G. Figueiredo-Pina, Rogério Colaço, and Ana P. Serro. 2022. "PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement" Gels 8, no. 3: 143. https://doi.org/10.3390/gels8030143