Next Article in Journal
Formulation of Transliposomal Nanocarrier Gel Containing Strychnine for the Effective Management of Skin Cancer
Next Article in Special Issue
Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential
Previous Article in Journal
Thermo-Responsive Sol-Gel-Based Nano-Carriers Containing Terbinafine HCl: Formulation, In Vitro and Ex Vivo Characterization, and Antifungal Activity
Previous Article in Special Issue
Balsam Poplar Buds Extracts-Loaded Gels and Emulgels: Development, Biopharmaceutical Evaluation, and Biological Activity In Vitro
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Gels
Volume 9
Issue 10
10.3390/gels9100832
gels-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis

by
Aqsa Afzal
1,
Syed Nisar Hussain Shah
2,*,
Hina Javed
1,
Asma Mumtaz
1,
Javeria Saeed
1,
Hafiz Majid Rasheed
2,*,
Rabia Arshad
2,
Siddique Akber Ansari
3,
Hamad M. Alkahtani
3 and
Irfan Aamer Ansari
4
1
Department of Pharmaceutics, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60000, Pakistan
2
Faculty of Pharmacy, The University of Lahore, Lahore 54590, Pakistan
3
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
4
Department of Drug Science and Technology, University of Turin, 10124 Turin, Italy
*
Authors to whom correspondence should be addressed.
Gels 2023, 9(10), 832; https://doi.org/10.3390/gels9100832
Submission received: 24 August 2023 / Revised: 13 October 2023 / Accepted: 17 October 2023 / Published: 20 October 2023
(This article belongs to the Special Issue Gel Role in the World of the Cosmetic Research)
Browse Figures
Versions Notes

Abstract

Background: Dermatitis is skin disorder that is complicated by recurrent infections of skin by bacteria, viruses, and fungi. Spilanthol is an active constituent of Spilanthes acmella, which possess strong anti-bacterial properties. The purpose of this study was to develop a herbal emulgel for the treatment of dermal bacterial infections, as microscopic organisms have created solid resistance against anti-microbials. Methods: Emulgels were prepared and characterized for parameters such as physical examination, rheological studies, spreading coefficient, bio-adhesive strength measurement, extrudability study, antibacterial activity, FTIR analysis, in vitro drug dissolution, and ex vivo permeation studies. Result: With a statistically significant p-value = 0.024, 100% antibacterial activity was observed by F4 against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli (mean ± S.D) (25.33 ± 0.28, 27.33 ± 0.5, and 27 ± 0.5). However, maximum antibacterial effect 100% formulations produced zones of inhibitions against E. colip-value = 0.001. The mean zone of inhibition produced by F4 was greatest among all at 26.44 ± 0.37 mm (mean ± S.D). The F4 formulation produced a maximum percentage dissolution, permeation, and flux of 86.35 ± 0.576, 55.29 ± 0.127%, and 0.5532 ug/cm2/min, respectively. Conclusions: The present study therefore, suggests the use of S. acmella extract and olive oil containing emulgel for treating bacterial skin infections.
Keywords: Spilanthes acmella; spilanthol; Staphylococcus aureus; Pseudomonas aeruginosa; Escherichia coli; emulgel Spilanthes acmella; spilanthol; Staphylococcus aureus; Pseudomonas aeruginosa; Escherichia coli; emulgel
Graphical Abstract

Share and Cite

MDPI and ACS Style

Afzal, A.; Shah, S.N.H.; Javed, H.; Mumtaz, A.; Saeed, J.; Rasheed, H.M.; Arshad, R.; Ansari, S.A.; Alkahtani, H.M.; Ansari, I.A. Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis. Gels 2023, 9, 832. https://doi.org/10.3390/gels9100832

AMA Style

Afzal A, Shah SNH, Javed H, Mumtaz A, Saeed J, Rasheed HM, Arshad R, Ansari SA, Alkahtani HM, Ansari IA. Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis. Gels. 2023; 9(10):832. https://doi.org/10.3390/gels9100832

Chicago/Turabian Style

Afzal, Aqsa, Syed Nisar Hussain Shah, Hina Javed, Asma Mumtaz, Javeria Saeed, Hafiz Majid Rasheed, Rabia Arshad, Siddique Akber Ansari, Hamad M. Alkahtani, and Irfan Aamer Ansari. 2023. "Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis" Gels 9, no. 10: 832. https://doi.org/10.3390/gels9100832

APA Style

Afzal, A., Shah, S. N. H., Javed, H., Mumtaz, A., Saeed, J., Rasheed, H. M., Arshad, R., Ansari, S. A., Alkahtani, H. M., & Ansari, I. A. (2023). Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis. Gels, 9(10), 832. https://doi.org/10.3390/gels9100832

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop