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Biomimetics
Volume 7
Issue 2
10.3390/biomimetics7020034
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Review
Peer-Review Record

Collagen-Based Biomaterials in Periodontal Regeneration: Current Applications and Future Perspectives of Plant-Based Collagen

Biomimetics 2022, 7(2), 34; https://doi.org/10.3390/biomimetics7020034
by Thunwa Binlateh 1, Peungchaleoy Thammanichanon 2, Pawornwan Rittipakorn 2, Natthapol Thinsathid 2 and Paiboon Jitprasertwong 2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Biomimetics 2022, 7(2), 34; https://doi.org/10.3390/biomimetics7020034
Submission received: 22 February 2022 / Revised: 9 March 2022 / Accepted: 23 March 2022 / Published: 24 March 2022

Round 1

Reviewer 1 Report

This review provides the current progresses of periodontal regeneration. Specifically, it was focused on current trends in preclinical, clinical research and the potential for clinical translatability in using collagen products as biomedical materials for hemostasis, wound healing, bone substitution and guided bone regeneration in periodontics. In addition, special attention in cellular mechanisms of collagen utilization as scaffolds/matrices for gene and cell regenerative therapies is presented. The manuscript needs minor revision.

The manuscript needs to check the English writing.

The new references in the field of the manuscript should be added especially from 2021 and 2022. For example, important references from new articles  PMCID: PMC7584591, PMID: 34931969 

 

 

 

 

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

This paper was intended to review the collagen application in the periodontal regenerative therapy, and it indeed had briefly introduced some basic concepts regarding this topic. However, the entire article digressed from the main subject and did not seems to bring significant contribution to the field as the following reasons:

 

First, the detailed review of the mechanisms of collagen application specifically for periodontal regenerative therapy was not provided. This is the foundation of the advantages of collagen as a promising products to be further improved.

 

Second, the clinical or preclinical status of the collagen products using the periodontal regenerative therapy should be clearly introduced for the readers to know how is the treatment outcome and what is to be improved.

 

Third, the research trend should be pointed out.

 

Overall, this article has provided indistinct information and no updates in this field.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 3 Report

Please see the attachment.

Comments for author File: Comments.pdf

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

The authors significantly improved their manuscript by addressing all the comments and suggestions. The actual version of the manuscript is ready to be published.

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