Journal of Mind and Medical Sciences

355 KiB

Open AccessCase Report

Perforated Small Intestine in a Patient with T-Cell Lymphoma; A Rare Cause of Peritonitis

by Petrişor Banu, Vlad D. Constantin, Florian Popa and Mihaela F. Nistor

J. Mind Med. Sci. 2016, 3(1), 88-98; https://doi.org/10.22543/2392-7674.1029 - 30 Mar 2016

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The nontraumatic perforations of the small intestine are pathological entities with particular aspects in respect to diagnosis and treatment. These peculiarities derive from the nonspecific clinical expression of the peritonitis syndrome, and from the multitude of causes that might be the primary sources [...] Read more.

The nontraumatic perforations of the small intestine are pathological entities with particular aspects in respect to diagnosis and treatment. These peculiarities derive from the nonspecific clinical expression of the peritonitis syndrome, and from the multitude of causes that might be the primary sources of the perforation: foreign bodies, inflammatory diseases, tumors, infectious diseases, etc. Accordingly, in most cases intestinal perforation is discovered only by laparotomy and the definitive diagnosis is available only after histopathologic examination. Small bowel malignancies are rare; among them, lymphomas rank third in frequency, being mostly B-cell non Hodgkin lymphomas. Only 10% of non-Hodgkin lymphomas are with T-cell. We report the case of a 57 years’ old woman with intestinal T-cell lymphoma, whose first clinical symptomatology was related to a complication represented by perforation of the small intestine. Laparotomy performed in emergency identified an ulcerative lesion with perforation in the jejunum, which required segmental enterectomy with anastomosis. The nonspecific clinical manifestations of intestinal lymphomas make from diagnosis a difficult procedure. Due to the fact that surgery does not have a definite place in the treatment of the small intestinal lymphomas (for cases complicated with perforation), and beyond the morbidity associated with the surgery performed in emergency conditions, prognosis of these patients is finally given by the possibility to control the systemic disease through adjuvant therapy. Full article

370 KiB

Open AccessCase Report

Cutis Verticis Gyrata in a Patient with Multiple Basal Cell Carcinomas; Case Presentation and Review of the Literature

by Simona-Roxana Georgescu, Maria Isabela Sârbu, Cristina-Iulia Mitran, Mădălina-Irina Mitran, Alice Rusu, Vasile Benea and Mircea Tampa

J. Mind Med. Sci. 2016, 3(1), 80-87; https://doi.org/10.22543/2392-7674.1040 - 30 Mar 2016

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Abstract

Cutis verticis gyrata is a rare disease characterized by convoluted folds and deep furrows of the scalp, resembling the gyri and sulci of the cerebral cortex. Basal cell carcinoma is the most frequent cancer in Caucasians, patients frequently presenting multiple tumors. We report [...] Read more.

Cutis verticis gyrata is a rare disease characterized by convoluted folds and deep furrows of the scalp, resembling the gyri and sulci of the cerebral cortex. Basal cell carcinoma is the most frequent cancer in Caucasians, patients frequently presenting multiple tumors. We report the case of a 62 year old male, Caucasian patient, from the urban area, who addressed the dermatology department of our hospital for multiple tumors located on the face and upper trunk. A careful examination revealed cerebriform folding of the skin of the scalp. Neurological, psychological, ophthalmological and endocrine disorders were disproven. The patient was diagnosed with cutis verticis gyrata based on the clinical picture and anamnesis, and basal cell carcinoma based on the histopathological examination. Since cutis verticis gyrata predated the BCCs by four decades, and no other conditions were associated, the patient was diagnosed with primary essential cutis verticis gyrata. Full article

216 KiB

Open AccessArticle

Finasteride Adverse Effects and Post-Finasteride Syndrome; Implications for Dentists

by Stana Paunica, Marina Giurgiu, Andrei Vasilache, Ioana Paunica, Ion Motofei, Adriana Vasilache, Horia Traian Dumitriu and Anca Silvia Dumitriu

J. Mind Med. Sci. 2016, 3(1), 71-79; https://doi.org/10.22543/2392-7674.1039 - 30 Mar 2016

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Abstract

Finasteride is a 5α-reductase inhibitor widely used in present in the therapeutic approach of androgenic alopecia. Adverse effects consist in variable sign and symptoms, the most common being represented by mental troubles (reduced feeling of life pleasure or emotions, depression), physical impairments (loss [...] Read more.

Finasteride is a 5α-reductase inhibitor widely used in present in the therapeutic approach of androgenic alopecia. Adverse effects consist in variable sign and symptoms, the most common being represented by mental troubles (reduced feeling of life pleasure or emotions, depression), physical impairments (loss of muscle tone and/or mass) and sexual complains (loss of libido and sexual potency). An increasing number of studies identify and describe even a post-finasteride syndrome (persistent adverse affects three months or more after finasteride cessation) or new adverse effects including but not limited at the skin level or oral cavity (marginal periodontium). We intend to present in this study several oral adverse effects encountered during finasteride administration, represented by mild and moderate signs which generally responded to topical procedures without to require the stop of the drug administration. New studies on large samples will further document the existing relation between the described oral adverse effects and the implied pathophysiological mechanisms. For this moment, we are taking into account as possible mechanisms- a direct action of finasteride administration, possible indirect consequences due to hormonal interferences, or coexisting factors with finasteride administration that were not detected. Full article

258 KiB

Open AccessArticle

Emergency Peripartum Hysterectomy, Physical and Mental Consequences: A 6-Year Study

by Denisa-Oana Bălălău, Romina Marina Sima, Nicolae Bacalbașa, Liana Pleș and Anca Daniela Stănescu

J. Mind Med. Sci. 2016, 3(1), 65-70; https://doi.org/10.22543/2392-7674.1035 - 30 Mar 2016

Viewed by 56

Abstract

Emergency peripartum hysterectomy (EPH) is performed for massive postpartum hemorrhage following a cesarean delivery or vaginal delivery, in order to save the patient’s life. The current study was performed on a sample of 13.162 patients, which underwent cesarean or vaginal delivery during a [...] Read more.

Emergency peripartum hysterectomy (EPH) is performed for massive postpartum hemorrhage following a cesarean delivery or vaginal delivery, in order to save the patient’s life. The current study was performed on a sample of 13.162 patients, which underwent cesarean or vaginal delivery during a period of 6 years, from 2010 to 2015, in Bucur Maternity Hospital. There were two subsequential groups consisting in: 6593 patients with cesarean operations and 6569 patients with vaginal delivery. In 12 cases occurred one or more of the risk factors that lead to EPH, divided equally across the two groups above. The main two types of surgery are a more frequent subtotal hysterectomy, which is the preferred type of EPH as it takes less time and is associated with fewer complications, and a total hysterectomy. The majority of procedures were performed at patients over 35 years old (9 of 12), with a median age of 31.16 (ranging from 21 to 44 years old). The most important risk factor present across the lot was multiparity (11 from 12), with cicatricial uterus being the second one (4 of 12). ICU median time was 4.5 days (ranging from 3 to 15 days), with a median blood transfusion necessity of around 2.4 I.U per patient. There were no mother or newborn reported deaths, neither PTSD following EPH.EPH is a procedure performed as last-resort, life-saving surgery, leaving no time for mental preparation of the patients. This may predispose to negative psychological outcomes, especially because they are not part of decision-making process due to the emergency character of hysterectomy. Full article

502 KiB

Open AccessArticle

Determination of Tramadol in Human Plasma by HPLC with Fluorescence Detection

by Daniela Baconi, Miriana Stan, Zainab Abdul Jalil Ebrahim, Cristian Tuchila and Cristian Balalau

J. Mind Med. Sci. 2016, 3(1), 55-64; https://doi.org/10.22543/2392-7674.1033 - 30 Mar 2016

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Abstract

Tramadol is a centrally acting analgesic, atypical opioid, and although it is generally considered as a medicinal drug with a low potential for dependence, there is growing evidence of tramadol abuse in some countries. The ultraviolet detection is not suitable for analysis of [...] Read more.

Tramadol is a centrally acting analgesic, atypical opioid, and although it is generally considered as a medicinal drug with a low potential for dependence, there is growing evidence of tramadol abuse in some countries. The ultraviolet detection is not suitable for analysis of tramadol in plasma, due to the lack of sensitivity and selectivity. However, it was shown that tramadol has a weak fluorescence, and the latest techniques for determination of tramadol in plasma include liquid chromatographic methods with fluorescence detection (FL). The objective of the paper was to develop a HPLC-FL method applicable for quantification of tramadol in human plasma.The separation was achieved by reverse phase HPLC method, using as stationary phase C18 – Kromasil^® column and a mobile phase consisted of acetonitrile: 0.1% formic acid (20:80). The fluorescence detection has been applied with λ_ex/_em= 280/310 nm. A solid phase extraction procedure using C18 cartridge was carried out. The linearity of the method has been demonstrated in the range of both therapeutic and toxic plasma tramadol levels (concentrations of 0.100 – 1 μg/mL). The selectivity, precision, and accuracy of the method have been demonstrated. The limit of detection (LOD = 0.010 μg/mL) and the limit of quantification (LOQ = 0.100 μg/mL) have been established.The proposed method can be used to assess tramadol levels in human plasma in pharmacokinetic studies, as well as in overdose cases. The utility of the method for the quantification of therapeutic levels of tramadol has been shown on the plasma samples from the patients with tramadol treatment as analgesic (doses ranging from 100 mg to 400 mg/day).The developed method is rapid, using simple experimental conditions and an accurate and short extraction procedure. Full article

683 KiB

Open AccessArticle

Differential Involvement of Hippocampal Angiotensin 1 Receptors in Learning and Memory Processes in Bulbectomized Rats

by Tashev E. Roman, Margarita S. Ivanova, Stiliana P. Belcheva and Iren P. Belcheva

J. Mind Med. Sci. 2016, 3(1), 39-54; https://doi.org/10.22543/2392-7674.1036 - 30 Mar 2016

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Abstract

There is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized (OBX) rats using active avoidance (shuttle box) test [...] Read more.

There is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized (OBX) rats using active avoidance (shuttle box) test and passive avoidance (step through) test were investigated. Rats were microinjected unilaterally through implanted guide cannulas into the CA1 area of the dorsal hippocampus and the drugs were administered separately, 5 minutes before each training session. The microinjections of losartan into the left, but not the right CA1 hippocampal area improved the acquisition and retention of active and passive avoidance learning, thus suggesting dependence on the side of injection. The unilateral (left or right) administration of angiotensin II did not significantly affect the performance of OBX rats in the avoidance tasks. A differential distribution of the AT1 receptors in the left and right hemisphere could contribute for the asymmetry in the behavioral effects of the AT receptor antagonist. Full article

263 KiB

Open AccessReview

Psychological Profile of Laryngectomized Patients

by Bogdan Popescu, Oana Păun, Răzvan V. Scăunașu, Cristian Bălălău and Șerban V. Berteșteanu

J. Mind Med. Sci. 2016, 3(1), 31-38; https://doi.org/10.22543/2392-7674.1031 - 30 Mar 2016

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Abstract

Larynx cancer is one of the most susceptible form of cancer susceptible to induce alteration of the patient’s psychological profile due to the social role that the larynx has in communication. Oral communication is severely impaired even after voice rehabilitation of the laryngectomized [...] Read more.

Larynx cancer is one of the most susceptible form of cancer susceptible to induce alteration of the patient’s psychological profile due to the social role that the larynx has in communication. Oral communication is severely impaired even after voice rehabilitation of the laryngectomized patients, so that the social rehabilitation is somewhat not only a medical but also a social problem. The psychological profile of these patients is altered in a way that dealing with the disease is sometimes neglected and the interaction with the outside world in terms of oral communication is totally abandoned. The starting point for depression in these cases is the acknowledgement of the disease and is, in some cases, the entire medical environment. Facial scarring, the inability to verbally interact with other human, as well as the presence of the tracheostoma, are all deciding factors in the presence of a low self-esteem for these particular patients. Psychological counseling is a mandatory approach for laryngectomized patients, in order to improve their ability to cope with cancer and providing better recovery chances. Full article

425 KiB

Open AccessReview

Pain in Photodynamic Therapy

by Mircea Tampa, Maria Isabela Sârbu, Mădălina-Irina Mitran, Cristina-Iulia Mitran, Adrian Dumitru, Vasile Benea and Simona-Roxana Georgescu

J. Mind Med. Sci. 2016, 3(1), 19-30; https://doi.org/10.22543/2392-7674.1038 - 30 Mar 2016

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Abstract

Photodynamic therapy is a modern treatment with applications in several medical specialties, which has been intensely studied in the last years. The main indications in dermatology are actinic keratosis, superficial basal cell carcinoma and Bowen's disease- common skin disorders in which photodynamic therapy [...] Read more.

Photodynamic therapy is a modern treatment with applications in several medical specialties, which has been intensely studied in the last years. The main indications in dermatology are actinic keratosis, superficial basal cell carcinoma and Bowen's disease- common skin disorders in which photodynamic therapy proved its efficacy. At present, the use of photodynamic therapy for the treatment of other skin disorders is profoundly researched. Pain is the most common and redoubtable adverse effect of photodynamic therapy and it is the most important factor affecting the patient's adherence to treatment. The aim of this article is to look over the most recent medical studies regarding pain in PDT, with emphasis on the factors affecting the occurrence of pain and the most recent strategies for controlling photodynamic therapy- related pain. Full article

267 KiB

Open AccessReview

Conservative Surgery of Breast Cancer in Women; Psychological Benefits

by Răzvan V. Scăunașu, Traean Burcoș, Ștefan Voiculescu, Bogdan Popescu, Șerban V. Berteșteanu, Oana-Denisa Bălălău, Nicolae Bacalbașa and Cristian Bălălău

J. Mind Med. Sci. 2016, 3(1), 13-18; https://doi.org/10.22543/2392-7674.1030 - 30 Mar 2016

Viewed by 55

Abstract

Breast surgery was one of the most dynamic fields of medicine which benefited from significant progress during the last decades. The transition from aggressive and mutilating amputations to conservative, oncoplastic and reconstructive techniques has been constant, offering improved and rewarding results, viewed from [...] Read more.

Breast surgery was one of the most dynamic fields of medicine which benefited from significant progress during the last decades. The transition from aggressive and mutilating amputations to conservative, oncoplastic and reconstructive techniques has been constant, offering improved and rewarding results, viewed from both, oncological and aesthetical perspectives. Conservative techniques, especially those which preserve the nipple areola complex, are followed by improved patient’s perception of their body image, confidence and sexuality, with the only drawback of increased anxiety linked to recurrence risk. Full article

281 KiB

Open AccessReview

The Mind Body Problem, Part Three: Ascension of Sexual Function to Cerebral Level

by Ion G. Motofei and David L. Rowland

J. Mind Med. Sci. 2016, 3(1), 1-12; https://doi.org/10.22543/2392-7674.1037 - 30 Mar 2016

Viewed by 27

Abstract

Physiologically, the somatic nervous system intervenes in external interaction between the body and environment, while autonomic nervous system ensures the functioning of internal organs. We present in this paper a psycho-physiological perspective suggesting that mental function (somatic in nature, because coordinates environmental interaction) [...] Read more.

Physiologically, the somatic nervous system intervenes in external interaction between the body and environment, while autonomic nervous system ensures the functioning of internal organs. We present in this paper a psycho-physiological perspective suggesting that mental function (somatic in nature, because coordinates environmental interaction) is closer to and more aligned with the physiologic functioning of autonomic nervous system (due to autonomy, duality, etc.). At opposite end, sexual function (autonomic in nature, erection for example being a parasympathetic vasodilatory reflex) seems to be compatible and even dependent by a somatic participation (erectile response is rather induced by environmental stimuli than internal visceral stimuli). The perspective presented here is that the mind and sexuality are two distinct relational processes which, being related to the same environmental stimuli/ peripheral afferents, should be supported by a common (somatic-autonomic) neurobiological substrate. Full article

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J. Mind Med. Sci., Volume 3, Issue 1 (March 2016) – 10 articles

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