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Volume 4
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10.22543/7674.42.P100114
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Journal of Mind and Medical Sciences is published by MDPI from Volume 12 Issue 1 (2025). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Valparaiso University (ValpoScholar).
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Review

Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine

by
Cristian Tuchila
1,
Daniela L. Baconi
1,*,
Cristina D. Pirvu
1,
Denisa O. Balalau
2,
Ana M. Vlasceanu
1,
Miriana Stan
1 and
Cristian Balalau
3
1
Department of Toxicology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
2
Bucur Maternity Hospital, Carol Davila University, Bucharest, Romania
3
St. Pantelimon Hospital, Carol Davila University, Bucharest, Romania
*
Author to whom correspondence should be addressed.
J. Mind Med. Sci. 2017, 4(2), 100-114; https://doi.org/10.22543/7674.42.P100114
Submission received: 1 August 2017 / Revised: 1 September 2017 / Accepted: 1 October 2017 / Published: 5 October 2017

Abstract

Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect. Carbamazepine metabolism has high inter-individual variability, such that it is relatively difficult to establish a direct link between dose and concentration, or between concentration and pharmacological effect. Carbamazepine is thus a good candidate for therapeutic drug monitoring (TDM). Good UV specific absorbance and high plasmatic concentrations allow for the use of UV detection, which is often more accessible than other methods of detection. This paper presents several methods used for the detection of carbamazepine in plasma, methods that are capable of detecting drug and metabolites at adequate levels/acceptance criteria. These methods have possible application not only in pharmacokinetic, bioequivalence, and permeability studies, but also in the therapeutic drug monitoring of carbamazepine.
Keywords: carbamazepine; therapeutic drug monitoring; bioanalytical method; validation; epilepsy carbamazepine; therapeutic drug monitoring; bioanalytical method; validation; epilepsy

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MDPI and ACS Style

Tuchila, C.; Baconi, D.L.; Pirvu, C.D.; Balalau, D.O.; Vlasceanu, A.M.; Stan, M.; Balalau, C. Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine. J. Mind Med. Sci. 2017, 4, 100-114. https://doi.org/10.22543/7674.42.P100114

AMA Style

Tuchila C, Baconi DL, Pirvu CD, Balalau DO, Vlasceanu AM, Stan M, Balalau C. Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine. Journal of Mind and Medical Sciences. 2017; 4(2):100-114. https://doi.org/10.22543/7674.42.P100114

Chicago/Turabian Style

Tuchila, Cristian, Daniela L. Baconi, Cristina D. Pirvu, Denisa O. Balalau, Ana M. Vlasceanu, Miriana Stan, and Cristian Balalau. 2017. "Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine" Journal of Mind and Medical Sciences 4, no. 2: 100-114. https://doi.org/10.22543/7674.42.P100114

APA Style

Tuchila, C., Baconi, D. L., Pirvu, C. D., Balalau, D. O., Vlasceanu, A. M., Stan, M., & Balalau, C. (2017). Therapeutic Drug Monitoring and Methods of Quantitation for Carbamazepine. Journal of Mind and Medical Sciences, 4(2), 100-114. https://doi.org/10.22543/7674.42.P100114

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