Combined Tuberculosis and Diabetes Mellitus Screening and Assessment of Glycaemic Control among Household Contacts of Tuberculosis Patients in Yangon, Myanmar
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Setting
2.2. Study Sample
2.3. Sample Size Calculation
2.4. Data Collection Tools
2.5. Diagnosis of DM in Index TB Patients and Household Contacts
2.6. Diagnosis of TB among Household Contacts
2.7. Data Collection Procedure
2.8. Data Analysis
2.9. Ethical Approval
3. Results
3.1. Investigation for DM among Index TB Patients
Prevalence of DM among Index TB Patients
3.2. Prevalence and Glycaemic Control of DM among Household Contacts
3.3. Prevalence of TB among Household Contacts
3.4. Comparing Prevalence of DM and TB among Household Contacts of Index TB Patients with and without DM
3.5. Number of Patients with DM among Household Contacts ≥ 25 Years Old
3.6. Odds Ratio of Getting DM and TB among Household Contacts Based on DM Status of Index TB Patients
4. Discussion
5. Limitations
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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DM Screening in Household Contacts | Total | Household Contacts of Index TB with DM | Household Contacts of Index TB without DM | p Value |
Number of household and household contact | ||||
Total number of households visited (a) | 193 | 63 | 130 | N/A |
Total number of household contacts screened for DM * (b) | 328 | 104 | 224 | N/A |
Number of DM patients | ||||
Known case of DM (c) | 33 | 15 | 18 | N/A |
Newly diagnosed DM (d) | 13 | 6 | 7 | N/A |
Prevalence of DM among household contacts, % (95%CI) | ||||
Overall DM ((c + d)/b) | 14.0 (10.6–18.4) | 20.2 (13.2–29.4) | 11.2 (7.5–16.2) | 0.03 |
Known case of DM (c/b) | 10.1 (7.1,13.9) | 14.4 (8.6–22.9) | 8.0 (4.9–12.6) | 0.07 |
Newly diagnosed DM (d/b) | 4.0 (2.2–6.9) | 5.8 (2.4–12.6) | 3.1 (1.4–6.6) | 0.36 † |
TB Screening in Household Contacts | Total | Household Contacts of Index TB with DM | Household Contacts of Index TB without DM | p Value |
Number of household and household contact | ||||
Total number of households visited (a) | 193 | 63 | 130 | N/A |
Total number of household contacts screened for TB (b) | 439 | 134 | 305 | N/A |
Number of TB patient | ||||
Known case of TB (c) | 1 | 0 | 1 | N/A |
Newly diagnosed TB (d) | 21 | 6 | 15 | N/A |
Prevalence of TB among household contacts, % (95%CI) | ||||
Overall TB prevalence ((c + d)/b) | 5.0 (3.2–7.6) | 4.5 (1.8–9.9) | 5.3 (3.1–8.6) | 0.73 |
Newly diagnosed TB (d/b) | 4.8 (3.1–7.3) | 4.5 (1.9–10.0) | 4.9 (2.9–8.2) | 0.84 |
Outcome—DM Status of Household Contacts | |||||||||
Model | Main Hypothesis Exposure | Covariate Included in the Model | OR (95% CI) | AIC | |||||
DM in Index TB Patient | Age | Gender | SES | Low Physical Activity | BMI | Central Obesity | |||
D1 | + | - | - | - | - | - | - | 2.01 (1.07–3.79) * | 265.4 |
D2 | + | + | - | - | - | - | - | 2.13 (1.10–4.12) * | 248.1 |
D3 | + | + | + | - | - | - | - | 2.24 (1.15–4.35) * | 248.3 |
D4 | + | + | + | + | - | - | - | 2.39 (1.22–4.72) * | 254.0 |
D5 | + | + | + | + | + | - | - | 2.37 (1.19–4.69) * | 253.5 |
D6 | + | + | + | + | + | + | - | 2.27 (1.13–4.56) * | 253.5 |
D7 | + | + | + | + | + | + | + | 2.28 (1.13–4.57) * | 254.6 |
Outcome—Active TB Status of Household Contacts | |||||||||
Model | Main Hypothesis Exposure | Covariate Included in the Model | OR (95% CI) | AIC | |||||
DM in Index TB Patient | Age | Gender | SES | Closeness to Index TB Patient | |||||
T1 | + | - | - | - | - | 0.85 (0.32–2.21) | 178.5 | ||
T2 | + | + | - | - | - | 0.85 (0.33–2.23) | 178.1 | ||
T3 | + | + | + | - | - | 0.82 (0.31–2.17) | 175.3 | ||
T4 | + | + | + | + | - | 0.81 (0.30–2.21) | 174.4 | ||
T5 | + | + | + | + | + | 0.87 (0.31–2.39) | 175.7 |
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Zayar, N.-N.; Sangthong, R.; Saw, S.; Aung, S.T.; Chongsuvivatwong, V. Combined Tuberculosis and Diabetes Mellitus Screening and Assessment of Glycaemic Control among Household Contacts of Tuberculosis Patients in Yangon, Myanmar. Trop. Med. Infect. Dis. 2020, 5, 107. https://doi.org/10.3390/tropicalmed5030107
Zayar N-N, Sangthong R, Saw S, Aung ST, Chongsuvivatwong V. Combined Tuberculosis and Diabetes Mellitus Screening and Assessment of Glycaemic Control among Household Contacts of Tuberculosis Patients in Yangon, Myanmar. Tropical Medicine and Infectious Disease. 2020; 5(3):107. https://doi.org/10.3390/tropicalmed5030107
Chicago/Turabian StyleZayar, Nyi-Nyi, Rassamee Sangthong, Saw Saw, Si Thu Aung, and Virasakdi Chongsuvivatwong. 2020. "Combined Tuberculosis and Diabetes Mellitus Screening and Assessment of Glycaemic Control among Household Contacts of Tuberculosis Patients in Yangon, Myanmar" Tropical Medicine and Infectious Disease 5, no. 3: 107. https://doi.org/10.3390/tropicalmed5030107